MedKoo Cat#: 527020 | Name: Diethylcarbamazine citrate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Diethylcarbamazine citrate is a muscle relaxant, causing general central nervous system depression, relieving pain caused by strains, sprains, and other musculoskeletal conditions.

Chemical Structure

Diethylcarbamazine citrate
CAS#1642-54-2 (citrate)

Theoretical Analysis

MedKoo Cat#: 527020

Name: Diethylcarbamazine citrate

CAS#: 1642-54-2 (citrate)

Chemical Formula: C16H29N3O8

Exact Mass: 391.1955

Molecular Weight: 391.42

Elemental Analysis: C, 49.10; H, 7.47; N, 10.74; O, 32.70

Price and Availability

Size Price Availability Quantity
100mg USD 250.00 2 Weeks
1g USD 550.00 2 Weeks
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Synonym
Diethylcarbamazine citrate; Hetrazan; Dicarocide; Loxuran;
IUPAC/Chemical Name
N,N-diethyl-4-methylpiperazine-1-carboxamide citrate
InChi Key
PGNKBEARDDELNB-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H21N3O.C6H8O7/c1-4-12(5-2)10(14)13-8-6-11(3)7-9-13;7-3(8)1-6(13,5(11)12)2-4(9)10/h4-9H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
SMILES Code
O=C(N1CCN(C)CC1)N(CC)CC.OC(C(O)=O)(CC(O)=O)CC(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 391.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Raveendran R. Lymph Node Enlargement in Neck Filariasis as a Rare Cause: A Case Report. Iran J Med Sci. 2017 Sep;42(5):493-496. PubMed PMID: 29234183; PubMed Central PMCID: PMC5722968. 2: Rao RU, Samarasekera SD, Nagodavithana KC, Dassanayaka TDM, Punchihewa MW, Ranasinghe USB, Weil GJ. Reassessment of areas with persistent Lymphatic Filariasis nine years after cessation of mass drug administration in Sri Lanka. PLoS Negl Trop Dis. 2017 Oct 30;11(10):e0006066. doi: 10.1371/journal.pntd.0006066. eCollection 2017 Oct. PubMed PMID: 29084213; PubMed Central PMCID: PMC5679644. 3: Al-Abd NM, Nor ZM, Junaid QO, Mansor M, Hasan MS, Kassim M. Antifilarial activity of caffeic acid phenethyl ester on Brugia pahangi in vitro and in vivo. Pathog Glob Health. 2017 Oct;111(7):388-394. doi: 10.1080/20477724.2017.1380946. Epub 2017 Oct 25. PubMed PMID: 29065795; PubMed Central PMCID: PMC5694892. 4: Lammie PJ, Eberhard ML, Addiss DG, Won KY, Beau de Rochars M, Direny AN, Milord MD, Lafontant JG, Streit TG. Translating Research into Reality: Elimination of Lymphatic Filariasis from Haiti. Am J Trop Med Hyg. 2017 Oct;97(4_Suppl):71-75. doi: 10.4269/ajtmh.16-0669. PubMed PMID: 29064364. 5: Kar SK, Dwibedi B, Das BK, Agrawala BK, Ramachandran CP, Horton J. Lymphatic pathology in asymptomatic and symptomatic children with Wuchereria bancrofti infection in children from Odisha, India and its reversal with DEC and albendazole treatment. PLoS Negl Trop Dis. 2017 Oct 23;11(10):e0005631. doi: 10.1371/journal.pntd.0005631. eCollection 2017 Oct. PubMed PMID: 29059186; PubMed Central PMCID: PMC5667936. 6: Global programme to eliminate lymphatic filariasis: progress report, 2016. Wkly Epidemiol Rec. 2017 Oct 6;92(40):594-607. English, French. PubMed PMID: 28984121. 7: de Souza DK, Ahorlu CS, Adu-Amankwah S, Otchere J, Mensah SK, Larbi IA, Mensah GE, Biritwum NK, Boakye DA. Community-based trial of annual versus biannual single-dose ivermectin plus albendazole against Wuchereria bancrofti infection in human and mosquito populations: study protocol for a cluster randomised controlled trial. Trials. 2017 Oct 2;18(1):448. doi: 10.1186/s13063-017-2196-9. PubMed PMID: 28969715; PubMed Central PMCID: PMC5625710. 8: Lau CL, Sheridan S, Ryan S, Roineau M, Andreosso A, Fuimaono S, Tufa J, Graves PM. Detecting and confirming residual hotspots of lymphatic filariasis transmission in American Samoa 8 years after stopping mass drug administration. PLoS Negl Trop Dis. 2017 Sep 18;11(9):e0005914. doi: 10.1371/journal.pntd.0005914. eCollection 2017 Sep. PubMed PMID: 28922418; PubMed Central PMCID: PMC5619835. 9: Ribeiro EL, Fragoso IT, Gomes FODS, Oliveira AC, Silva AKSE, Silva PME, Ciambarella BT, Ramos IPR, Peixoto CA. Diethylcarbamazine: A potential treatment drug for pulmonary hypertension? Toxicol Appl Pharmacol. 2017 Oct 15;333:92-99. doi: 10.1016/j.taap.2017.08.015. Epub 2017 Aug 26. PubMed PMID: 28851623. 10: Coutts SP, King JD, Pa'au M, Fuimaono S, Roth J, King MR, Lammie PJ, Lau CL, Graves PM. Prevalence and risk factors associated with lymphatic filariasis in American Samoa after mass drug administration. Trop Med Health. 2017 Aug 4;45:22. doi: 10.1186/s41182-017-0063-8. eCollection 2017. PubMed PMID: 28794687; PubMed Central PMCID: PMC5543440. 11: Kshirsagar NA, Gogtay NJ, Garg BS, Deshmukh PR, Rajgor DD, Kadam VS, Thakur PA, Gupta A, Ingole NS, Lazdins-Helds JK. Efficacy and tolerability of treatment with single doses of diethylcarbamazine (DEC) and DEC plus albendazole (ABZ) for three consecutive years in lymphatic filariasis: a field study in India. Parasitol Res. 2017 Oct;116(10):2683-2694. doi: 10.1007/s00436-017-5577-9. Epub 2017 Aug 7. PubMed PMID: 28785847. 12: Smith ME, Singh BK, Michael E. Assessing endgame strategies for the elimination of lymphatic filariasis: A model-based evaluation of the impact of DEC-medicated salt. Sci Rep. 2017 Aug 7;7(1):7386. doi: 10.1038/s41598-017-07782-9. PubMed PMID: 28785097; PubMed Central PMCID: PMC5547057. 13: Rodrigues GB, Oliveira EE, Junior FJBM, Santos LAMD, Oliveira WH, França MER, Lós DB, Gabínio BM, de Lira FCML, Peixoto CA. Characterization and evaluation of nanoencapsulated diethylcarbamazine in model of acute hepatic inflammation. Int Immunopharmacol. 2017 Sep;50:330-337. doi: 10.1016/j.intimp.2017.07.014. PubMed PMID: 28743082. 14: GheorghiŢă MI, ForŢofoiu MC, Dumitrescu CI, Dumitrescu D, Camen A, Mărgăritescu C. Intramuscular human Dirofilaria repens infection of the temporal region - case report and review of the literature. Rom J Morphol Embryol. 2017;58(2):585-592. PubMed PMID: 28730247. 15: Ojha CR, Joshi B, Kc KP, Dumre SP, Yogi KK, Bhatta B, Adhikari T, Crowley K, Marasini BR. Impact of mass drug administration for elimination of lymphatic filariasis in Nepal. PLoS Negl Trop Dis. 2017 Jul 19;11(7):e0005788. doi: 10.1371/journal.pntd.0005788. eCollection 2017 Jul. PubMed PMID: 28723904; PubMed Central PMCID: PMC5536438. 16: Taleo F, Taleo G, Graves PM, Wood P, Kim SH, Ozaki M, Joseph H, Chu B, Pavluck A, Yajima A, Melrose W, Ichimori K, Capuano C. Surveillance efforts after mass drug administration to validate elimination of lymphatic filariasis as a public health problem in Vanuatu. Trop Med Health. 2017 Jun 16;45:18. doi: 10.1186/s41182-017-0057-6. eCollection 2017. PubMed PMID: 28630586; PubMed Central PMCID: PMC5472907. 17: Kausar S, Khan W. Immunopathological response of leukocytes against microfilariae and adult worms in white rats infected with Setaria cervi. Vet World. 2017 May;10(5):562-568. doi: 10.14202/vetworld.2017.562-568. Epub 2017 May 30. PubMed PMID: 28620263; PubMed Central PMCID: PMC5465773. 18: Jia G, Zao M, Liu X. Protective effect of diethylcarbamazine inhibits NF-κB activation in isoproterenol-induced acute myocardial infarction rat model through the PARP pathway. Mol Med Rep. 2017 Aug;16(2):1596-1602. doi: 10.3892/mmr.2017.6695. Epub 2017 Jun 6. PubMed PMID: 28586070. 19: Nieves-Moreno M, Bañeros-Rojas P, Díaz-Valle D, Gegúndez-Fernández JA. Encephalitis secondary to diethylcarbamazine treatment in a patient with ocular loiasis. J Fr Ophtalmol. 2017 Jun;40(6):e229-e230. doi: 10.1016/j.jfo.2015.12.012. Epub 2017 May 31. PubMed PMID: 28579217. 20: Jones C, Ngasalla B, Derua YA, Tarimo D, Malecela MN. Lymphatic filariasis elimination efforts in Rufiji, southeastern Tanzania: decline in circulating filarial antigen prevalence in young school children after twelve rounds of mass drug administration and utilization of long-lasting insecticide-treated nets. Int J Infect Dis. 2017 Aug;61:38-43. doi: 10.1016/j.ijid.2017.05.009. Epub 2017 May 17. PubMed PMID: 28527817; PubMed Central PMCID: PMC5521953.