MedKoo Cat#: 463072 | Name: ShERPA BMI-135

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ShERPA BMI-135 is a novel Selective Human ER Partial Agonist (ShERPA).

Chemical Structure

ShERPA BMI-135
ShERPA BMI-135
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 463072

Name: ShERPA BMI-135

CAS#: unknown

Chemical Formula: C22H13FOS

Exact Mass: 344.0671

Molecular Weight: 344.40

Elemental Analysis: C, 76.72; H, 3.80; F, 5.52; O, 4.65; S, 9.31

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
ShERPA BMI-135; ShERPA BMI135; ShERPA BMI 135;
IUPAC/Chemical Name
2-(4-ethynylphenyl)-3-(4-fluorophenyl)benzo[b]thiophen-6-ol
InChi Key
WNVCCXNDDYZWGU-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H13FOS/c1-2-14-3-5-16(6-4-14)22-21(15-7-9-17(23)10-8-15)19-12-11-18(24)13-20(19)25-22/h1,3-13,24H
SMILES Code
OC1=CC=C(C(C2=CC=C(F)C=C2)=C(C3=CC=C(C#C)C=C3)S4)C4=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 344.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Abderrahman B, Maximov PY, Curpan RF, Hanspal JS, Fan P, Xiong R, Tonetti DA, Thatcher GRJ, Jordan VC. Pharmacology and Molecular Mechanisms of Clinically Relevant Estrogen Estetrol and Estrogen Mimic BMI-135 for the Treatment of Endocrine-Resistant Breast Cancer. Mol Pharmacol. 2020 Oct;98(4):364-381. doi: 10.1124/molpharm.120.000054. Epub 2020 Aug 12. Erratum in: Mol Pharmacol. 2020 Oct;98(4):528. PMID: 32788222.