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MedKoo Cat#: 599264 | Name: Diethylcarbamazine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Diethylcarbamazine is an anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa.

Chemical Structure

Diethylcarbamazine
CAS#90-89-1 (free base)

Theoretical Analysis

MedKoo Cat#: 599264

Name: Diethylcarbamazine

CAS#: 90-89-1 (free base)

Chemical Formula: C10H21N3O

Exact Mass: 199.1685

Molecular Weight: 199.29

Elemental Analysis: C, 60.27; H, 10.62; N, 21.08; O, 8.03

Price and Availability

Size Price Availability Quantity
1g USD 250.00 2 Weeks
5g USD 550.00 2 Weeks
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Related CAS #
90-89-1 (free base) 1642-54-2 (citrate)
Synonym
Diethylcarbamazine; Diethyl carbamazine; Carbamazine; RP 3799; RP-3799; RP3799; Bitirazine; Diaethylcarbamazinum;
IUPAC/Chemical Name
N,N-diethyl-4-methylpiperazine-1-carboxamide
InChi Key
RCKMWOKWVGPNJF-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H21N3O/c1-4-12(5-2)10(14)13-8-6-11(3)7-9-13/h4-9H2,1-3H3
SMILES Code
O=C(N1CCN(C)CC1)N(CC)CC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 199.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Abdel-Latif M, Sakran T, El-Shahawi G, El-Fayoumi H, El-Mallah AM. Effect of diethylcarbamazine citrate and Setaria equina excretory-secretory material on rat hepatocellular carcinoma. Arch Immunol Ther Exp (Warsz). 2014 Dec;62(6):511-20. doi: 10.1007/s00005-014-0292-z. Epub 2014 May 31. PubMed PMID: 24879096. 2: Siram K, Chellan VR, Natarajan T, Krishnamoorthy B, Mohamed Ebrahim HR, Karanam V, Muthuswamy SS, Ranganathan HP. Solid lipid nanoparticles of diethylcarbamazine citrate for enhanced delivery to the lymphatics: in vitro and in vivo evaluation. Expert Opin Drug Deliv. 2014 Sep;11(9):1351-65. doi: 10.1517/17425247.2014.915310. Epub 2014 May 21. PubMed PMID: 24847779. 3: Awadzi K, Opoku NO, Attah SK, Lazdins-Helds JK, Kuesel AC. Diagnosis of O. volvulus infection via skin exposure to diethylcarbamazine: clinical evaluation of a transdermal delivery technology-based patch. Parasit Vectors. 2015 Oct 9;8:515. doi: 10.1186/s13071-015-1122-9. PubMed PMID: 26452723; PubMed Central PMCID: PMC4598973. 4: Schmidt MS, King CL, Thomsen EK, Siba PM, Sanuku N, Fleckenstein L. Liquid chromatography-mass spectrometry analysis of diethylcarbamazine in human plasma for clinical pharmacokinetic studies. J Pharm Biomed Anal. 2014 Sep;98:307-10. doi: 10.1016/j.jpba.2014.05.016. Epub 2014 May 22. PubMed PMID: 24975211. 5: Honorato SB, da Silva CC, de Oliveira YS, Mendonça JS, Boechat N, Ellena J, Ayala AP. On the Thermal Stability of the Diethylcarbamazine-Fortified Table Salt Used in the Control of Lymphatic Filariasis. J Pharm Sci. 2016 Aug;105(8):2437-43. doi: 10.1016/j.xphs.2016.06.003. Epub 2016 Jul 7. PubMed PMID: 27397435. 6: Thomsen EK, Sanuku N, Baea M, Satofan S, Maki E, Lombore B, Schmidt MS, Siba PM, Weil GJ, Kazura JW, Fleckenstein LL, King CL. Efficacy, Safety, and Pharmacokinetics of Coadministered Diethylcarbamazine, Albendazole, and Ivermectin for Treatment of Bancroftian Filariasis. Clin Infect Dis. 2016 Feb 1;62(3):334-341. doi: 10.1093/cid/civ882. Epub 2015 Oct 20. PubMed PMID: 26486704. 7: Santos Rocha SW, Silva BS, Gomes FO, Soares e Silva AK, Raposo C, Barbosa KP, Torres Dde O, dos Santos AC, Peixoto CA. Effect of diethylcarbamazine on chronic hepatic inflammation induced by alcohol in C57BL/6 mice. Eur J Pharmacol. 2012 Aug 15;689(1-3):194-203. doi: 10.1016/j.ejphar.2012.05.044. Epub 2012 Jun 7. PubMed PMID: 22683874. 8: Bockarie MJ, Tavul L, Ibam I, Kastens W, Hazlett F, Tisch DJ, Alpers MP, Kazura JW. Efficacy of single-dose diethylcarbamazine compared with diethylcarbamazine combined with albendazole against Wuchereria bancrofti infection in Papua New Guinea. Am J Trop Med Hyg. 2007 Jan;76(1):62-6. PubMed PMID: 17255231. 9: Lima AW, Medeiros Z, Santos ZC, Costa GM, Braga C. Adverse reactions following mass drug administration with diethylcarbamazine in lymphatic filariasis endemic areas in the Northeast of Brazil. Rev Soc Bras Med Trop. 2012 Dec;45(6):745-50. PubMed PMID: 23295880. 10: Wamae CN, Njenga SM, Ngugi BM, Mbui J, Njaanake HK. Evaluation of effectiveness of diethylcarbamazine/albendazole combination in reduction of Wuchereria bancrofti infection using multiple infection parameters. Acta Trop. 2011 Sep;120 Suppl 1:S33-8. doi: 10.1016/j.actatropica.2010.09.009. Epub 2010 Oct 8. PubMed PMID: 20933491. 11: Greene BM, Taylor HR, Cupp EW, Murphy RP, White AT, Aziz MA, Schulz-Key H, D'Anna SA, Newland HS, Goldschmidt LP, et al. Comparison of ivermectin and diethylcarbamazine in the treatment of onchocerciasis. N Engl J Med. 1985 Jul 18;313(3):133-8. PubMed PMID: 3892293. 12: Nutman TB, Miller KD, Mulligan M, Reinhardt GN, Currie BJ, Steel C, Ottesen EA. Diethylcarbamazine prophylaxis for human loiasis. Results of a double-blind study. N Engl J Med. 1988 Sep 22;319(12):752-6. PubMed PMID: 3166107. 13: Hoti SL, Pani SP, Vanamail P, Athisaya Mary K, Das LK, Das PK. Effect of a single dose of diethylcarbamazine, albendazole or both on the clearance of Wuchereria bancrofti microfilariae and antigenaemia among microfilaria carriers: a randomized trial. Natl Med J India. 2010 Mar-Apr;23(2):72-6. PubMed PMID: 20925201. 14: Taylor HR, Murphy RP, Newland HS, White AT, D'Anna SA, Keyvan-Larijani E, Aziz MA, Cupp EW, Greene BM. Treatment of onchocerciasis. The ocular effects of ivermectin and diethylcarbamazine. Arch Ophthalmol. 1986 Jun;104(6):863-70. PubMed PMID: 3521559. 15: Orisakwe OE, Ilondu ND, Afonne OJ, Ofoefule SI, Orish CN, Agbasi PU. Effect of activated charcoal on diethylcarbamazine absorption in humans. Am J Ther. 2001 Jan-Feb;8(1):7-9. PubMed PMID: 11304652. 16: Ali M, Afzal M, Verma M, Bhattacharya SM, Ahmad FJ, Samim M, Abidin MZ, Dinda AK. Therapeutic efficacy of poly (lactic-co-glycolic acid) nanoparticles encapsulated ivermectin (nano-ivermectin) against brugian filariasis in experimental rodent model. Parasitol Res. 2014 Feb;113(2):681-91. doi: 10.1007/s00436-013-3696-5. Epub 2013 Dec 24. PubMed PMID: 24366812. 17: Ottesen EA, Vijayasekaran V, Kumaraswami V, Perumal Pillai SV, Sadanandam A, Frederick S, Prabhakar R, Tripathy SP. A controlled trial of ivermectin and diethylcarbamazine in lymphatic filariasis. N Engl J Med. 1990 Apr 19;322(16):1113-7. PubMed PMID: 2181312. 18: McCall JW, Ziegler JB. Antifilarial agents. 1,2-Cyclobutanediamines as analogues of diethylcarbamazine. Status of structure-activity relationships among diethylcarbamazine analogues. J Med Chem. 1977 Oct;20(10):1327-33. PubMed PMID: 903919. 19: Itoh M, Weerasooriya MV, Yahathugoda TC, Takagi H, Samarawickrema WA, Nagaoka F, Kimura E. Effects of 5 rounds of mass drug administration with diethylcarbamazine and albendazole on filaria-specific IgG4 titers in urine: 6-year follow-up study in Sri Lanka. Parasitol Int. 2011 Dec;60(4):393-7. doi: 10.1016/j.parint.2011.06.019. Epub 2011 Jun 24. PubMed PMID: 21723413. 20: Adhikari RK, Sherchand JB, Mishra SR, Ranabhat K, Wagle RR. Awareness and coverage of mass drug administration for elimination of lymphatic filariasis: a community based cross sectional study in Nepal. J Community Health. 2015 Feb;40(1):34-40. doi: 10.1007/s10900-014-9891-1. PubMed PMID: 24996654.