DG167 | CAS#unknown | KasA inhibitor

MedKoo Cat#: 464617 | Name: DG167

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DG167, also known as GSK3011724A, is a novel binary inhibitor of β-ketoacyl-ACP synthase (KasA) in Mycobacterium tuberculosis Genetic and biochemical studies established KasA.

Chemical Structure

DG167

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464617

Name: DG167

CAS#: unknown

Chemical Formula: C12H17N3O2S

Exact Mass: 267.1041

Molecular Weight: 267.35

Elemental Analysis: C, 53.91; H, 6.41; N, 15.72; O, 11.97; S, 11.99

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

DG167; DG 167; DG-167; MMV687145; MMV 687145; MMV-687145; GSK3011724A; GSK 3011724A; GSK-3011724A;

IUPAC/Chemical Name

N-(1-methyl-1H-indazol-6-yl)butane-1-sulfonamide

InChi Key

DDWBORAVXJGWPK-UHFFFAOYSA-N

InChi Code

InChI=1S/C12H17N3O2S/c1-3-4-7-18(16,17)14-11-6-5-10-9-13-15(2)12(10)8-11/h5-6,8-9,14H,3-4,7H2,1-2H3

SMILES Code

CCCCS(=O)(NC1=CC2=C(C=C1)C=NN2C)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 267.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Grzegorzewicz AE, Lelièvre J, Esquivias J, Angala B, Liu J, Lee RE, McNeil MR, Jackson M. Lack of Specificity of Phenotypic Screens for Inhibitors of the Mycobacterium tuberculosis FAS-II System. Antimicrob Agents Chemother. 2020 Dec 16;65(1):e01914-20. doi: 10.1128/AAC.01914-20. PMID: 33139282; PMCID: PMC7927822. 2: Cunningham F, Esquivias J, Fernández-Menéndez R, Pérez A, Guardia A, Escribano J, Rivero C, Vimal M, Cacho M, de Dios-Antón P, Martínez-Martínez MS, Jiménez E, Huertas Valentín L, Rebollo-López MJ, López-Román EM, Sousa-Morcuende V, Rullas J, Neu M, Chung CW, Bates RH. Exploring the SAR of the β-Ketoacyl-ACP Synthase Inhibitor GSK3011724A and Optimization around a Genotoxic Metabolite. ACS Infect Dis. 2020 May 8;6(5):1098-1109. doi: 10.1021/acsinfecdis.9b00493. Epub 2020 Mar 20. PMID: 32196311. 3: Kumar P, Capodagli GC, Awasthi D, Shrestha R, Maharaja K, Sukheja P, Li SG, Inoyama D, Zimmerman M, Ho Liang HP, Sarathy J, Mina M, Rasic G, Russo R, Perryman AL, Richmann T, Gupta A, Singleton E, Verma S, Husain S, Soteropoulos P, Wang Z, Morris R, Porter G, Agnihotri G, Salgame P, Ekins S, Rhee KY, Connell N, Dartois V, Neiditch MB, Freundlich JS, Alland D. Synergistic Lethality of a Binary Inhibitor of Mycobacterium tuberculosis KasA. mBio. 2018 Dec 18;9(6):e02101-17. doi: 10.1128/mBio.02101-17. PMID: 30563908; PMCID: PMC6299220. 4: Abrahams KA, Chung CW, Ghidelli-Disse S, Rullas J, Rebollo-López MJ, Gurcha SS, Cox JA, Mendoza A, Jiménez-Navarro E, Martínez-Martínez MS, Neu M, Shillings A, Homes P, Argyrou A, Casanueva R, Loman NJ, Moynihan PJ, Lelièvre J, Selenski C, Axtman M, Kremer L, Bantscheff M, Angulo-Barturen I, Izquierdo MC, Cammack NC, Drewes G, Ballell L, Barros D, Besra GS, Bates RH. Identification of KasA as the cellular target of an anti-tubercular scaffold. Nat Commun. 2016 Sep 1;7:12581. doi: 10.1038/ncomms12581. PMID: 27581223; PMCID: PMC5025758.