Sarafloxacin HCl | CAS#91296-87-6 | antibacterial

MedKoo Cat#: 561622 | Name: Sarafloxacin HCl

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sarafloxacin HCl is a broad-spectrum fluoroquinolone antibacterial agent. It inhibits bacterial Topo II α (DNA gyrase, topoisomerase) and is effective against Mycobacterium tuberculosis.

Chemical Structure

Sarafloxacin HCl

CAS#91296-87-6

Theoretical Analysis

MedKoo Cat#: 561622

Name: Sarafloxacin HCl

CAS#: 91296-87-6

Chemical Formula: C20H18ClF2N3O3

Exact Mass: 0.0000

Molecular Weight: 421.83

Elemental Analysis: C, 56.95; H, 4.30; Cl, 8.40; F, 9.01; N, 9.96; O, 11.38

Price and Availability

Size	Price	Availability	Quantity
1g	USD 400.00	2 weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

Sarafloxacin HCl; Sarafloxacin Hydrochloride; A-56620; A 56620; A56620;

IUPAC/Chemical Name

6-Fluoro-1-(4-fluorophenyl)-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid;hydrochloride

InChi Key

KNWODGJQLCISLC-UHFFFAOYSA-N

InChi Code

InChI=1S/C20H17F2N3O3.ClH/c21-12-1-3-13(4-2-12)25-11-15(20(27)28)19(26)14-9-16(22)18(10-17(14)25)24-7-5-23-6-8-24;/h1-4,9-11,23H,5-8H2,(H,27,28);1H

SMILES Code

O=C(C1=CN(C2=CC=C(F)C=C2)C3=C(C=C(F)C(N4CCNCC4)=C3)C1=O)O.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Sarafloxacin HCl is a hydrochloride salt form of sarafloxacin, a quinolone antibiotic drug with IC50 of 0.96 μg/L.

In vitro activity:

Sarafloxacin, serving as a model for fluoroquinolones, was examined for its absorption kinetics in Caco-2 cells. The study aimed to understand the mechanisms behind its intestinal transport. In Caco-2 cells, sarafloxacin demonstrated concentration-dependent permeability in both directions, suggesting the involvement of absorption and efflux carriers. These findings shed light on the complexities of sarafloxacin's absorption and transport mechanisms. Reference: J Drug Target. 2005 Apr;13(3):199-212. https://pubmed.ncbi.nlm.nih.gov/16036308/

In vivo activity:

In a study involving Muscovy ducks and avian pathogenic Escherichia coli O78, sarafloxacin was investigated to optimize therapeutic dosages. After intravenous and oral administration, the calculated area under the concentration-time curves were similar, and elimination half-lives varied. A higher dose of sarafloxacin may be needed for effective treatment of E. coli O78 infections, particularly to minimize antimicrobial resistance. Reference: BMC Vet Res. 2017 Feb 10;13(1):47. https://pubmed.ncbi.nlm.nih.gov/28183350/

	Solvent	mg/mL	mM
Solubility
	DMSO	4.0	9.48

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 421.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Fernandez-Teruel C, Gonzalez-Alvarez I, Casabó VG, Ruiz-Garcia A, Bermejo M. Kinetic modelling of the intestinal transport of sarafloxacin. Studies in situ in rat and in vitro in Caco-2 cells. J Drug Target. 2005 Apr;13(3):199-212. doi: 10.1080/10611860500087835. PMID: 16036308. 2. McConville ML, Dijkstra JW, Stamm JM, van Saene JJ, Nouws JF. Effects of sarafloxacin hydrochloride on human enteric bacteria under simulated human gut conditions. Vet Q. 1995 Mar;17(1):1-5. doi: 10.1080/01652176.1995.9694519. PMID: 7610549. 3. Yu Y, Zhou YF, Sun J, Shi W, Liao XP, Liu YH. Pharmacokinetic and pharmacodynamic modeling of sarafloxacin against avian pathogenic Escherichia coli in Muscovy ducks. BMC Vet Res. 2017 Feb 10;13(1):47. doi: 10.1186/s12917-017-0964-0. PMID: 28183350; PMCID: PMC5301423. 4. Johnson, M.R., K.L. Smith, and C.R. Boyle, Field efficacy trials of the antibacterial sarafloxacin-hydrochloride (A-56620) for treatment of Edwardsiella ictaluri infections in channel catfish. Journal of aquatic animal health, 1992. 4(4): p. 244-251.

In vitro protocol:

In vivo protocol:

1. Yu Y, Zhou YF, Sun J, Shi W, Liao XP, Liu YH. Pharmacokinetic and pharmacodynamic modeling of sarafloxacin against avian pathogenic Escherichia coli in Muscovy ducks. BMC Vet Res. 2017 Feb 10;13(1):47. doi: 10.1186/s12917-017-0964-0. PMID: 28183350; PMCID: PMC5301423. 2. Johnson, M.R., K.L. Smith, and C.R. Boyle, Field efficacy trials of the antibacterial sarafloxacin-hydrochloride (A-56620) for treatment of Edwardsiella ictaluri infections in channel catfish. Journal of aquatic animal health, 1992. 4(4): p. 244-251.

1: Evaluation of certain veterinary drug residues in food. Fiftieth report of the joint FAO/WHO Expert Committee on Food Additives. World Health Organ Tech Rep Ser. 1999;888:i-vii, 1-95. Review. PubMed PMID: 10416362. 2: Gingerich WH, Stehly GR, Clark KJ, Hayton WL. Crop grouping: a proposal for public aquaculture. Vet Hum Toxicol. 1998;40 Suppl 2:24-31. Review. PubMed PMID: 9823579.