Cyacetacide | CAS# 140-87-4 | Anti-tuberculosis Agent

MedKoo Cat#: 571314 | Name: Cyacetacide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cyacetacide is a biochemical used in the past as an anti-tuberculosis agent. It has also been used to derive compounds that may have antitumor properties.

Chemical Structure

Cyacetacide

CAS#140-87-4 (free base)

Theoretical Analysis

MedKoo Cat#: 571314

Name: Cyacetacide

CAS#: 140-87-4 (free base)

Chemical Formula: C3H5N3O

Exact Mass: 99.0433

Molecular Weight: 99.09

Elemental Analysis: C, 36.36; H, 5.09; N, 42.41; O, 16.15

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

140-87-4 (free base) 5897-13-2 (HCl)

Synonym

Cyanoacetic acid hydrazide; AB 42; AB-42; AB42; NSC 24261; NSC-24261; NSC24261

IUPAC/Chemical Name

Acetic acid, cyano-, hydrazide

InChi Key

HPHBOJANXDKUQD-UHFFFAOYSA-N

InChi Code

InChI=1S/C3H5N3O/c4-2-1-3(7)6-5/h1,5H2,(H,6,7)

SMILES Code

O=C(NN)CC#N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 99.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: POTWOROWSKA M. [Cyanoacetic acid hydrazide]. Gruzlica. 1956 Feb;24(2):129-36. Polish. PubMed PMID: 13345091. 2: KOCH J, BAUDET P, BRISK DT. [Comparative determination of blood concentrations of the cyanoacetic acid hydrazide and isonicotinic acid hydrazide]. Schweiz Z Tuberc Pneumonol. 1956;13(2):139-47. German. PubMed PMID: 13351610. 3: SEREMBE M. [Cyanoacetic acid hydrazide, a new drug in therapy of tuberculosis; antibacterial effect in vitro]. Minerva Med. 1955 Sep 1;46(70):460-2. Italian. PubMed PMID: 13265319. 4: SEREMBE M. [Cyanoacetic acid hydrazide, a new drug in therapy of tuberculosis; clinical study with pulmonary tuberculosis patients]. Minerva Med. 1955 Sep 1;46(70):462-8. Italian. PubMed PMID: 13265320. 5: BARNETT M, BUSHBY SR, GOULDING R, KNOX R, ROBSON JM. Antituberculous activity of cyanacetic acid hydrazide. Br Med J. 1955 Sep 10;2(4940):647-9. PubMed PMID: 13240207; PubMed Central PMCID: PMC1980835. 6: SISTI MA, SCODITTI G. [Effect of cyanacetic acid hydrazide in anti-tuberculosis therapy on indices of organic resistance; clinico-functional studies]. Lotta Tuberc. 1957 Sep;27(9):760-2 passim. Italian. PubMed PMID: 13515423. 7: BARTOVA D, KALURIK M, GROSS J, HOSAK L. [Experience with the treatment of male sexual disorders with cyanazide]. Act Nerv Super (Praha). 1961 May;3:224-5. Czech. PubMed PMID: 13865518. 8: SEREMBE M, ZILIOTTO G. [Cyanacetic acid hydrazide in experimental tuberculosis in mice]. Arch Tisiol Mal Appar Respir. 1957 Dec;12(12):1031-51. Italian. PubMed PMID: 13509979. 9: MARESCH K, PHILIPPI E. [Determination of cyanoacetic acid hydrazide in blood]. Wien Med Wochenschr. 1956 Jun 2;106(22):505-6. German. PubMed PMID: 13353137. 10: SEREMBE M. [A new anti-tuberculosis chemotherapeutic drug: cyanoacetic acid hydrazide; absorption and elimination in humans]. Minerva Med. 1955 Oct 27;46(86):1141-4. Italian. PubMed PMID: 13279747. 11: GONZALEZ MENDOZA A, FERNANDO BASTARRACHEA A. [Comparative effects of cyanacetic acid hydrazide & isoniazid in experimental tuberculosis]. Rev Mex Tuberc Enferm Apar Respir. 1957 May-Jun;18(3):281-8. Spanish. PubMed PMID: 24544787. 12: KLOSA J. [Various hydrazones of cyanoacetic acid hydrazide. IV. Synthesis of tuberculostatic substances]. Arch Pharm Ber Dtsch Pharm Ges. 1954;287(5):302-4. German. PubMed PMID: 13198199. 13: JAROS M, GROSS J, HOSAK L. ["Effect of cyanacetic acid hydrazide on higher nervous activity in normal subjects"]. Act Nerv Super (Praha). 1961 May;3:206-7. Czech. PubMed PMID: 14451321. 14: HECHT A. [Report on experiences with cyanoacetic acid hydrazide treatment of tuberculosis (reazide therapy)]. Tuberkulosearzt. 1957 May;11(5):286-92. German. PubMed PMID: 13455792. 15: KLOSA J. [Synthesis of various cyanoacetic acid hydrazide derivatives. VII. Synthesis of tuberculostatic agents]. Arch Pharm Ber Dtsch Pharm Ges. 1955;288(10):452-5. German. PubMed PMID: 13373351. 16: BANCHETTI A. [Control of various pharmaceutical products. II. Glucuronolactone isonicotinylhydrazone and cyanoacetic acid hydrazide]. Farmaco Sci. 1955;10(12):980-3. Italian. PubMed PMID: 13294179. 17: SEREMBE M. [Cyanoacetic acid hydrazide, a new drug in therapy of tuberculosis; pharmacological study]. Minerva Med. 1955 Sep 1;46(70):453-60. Italian. PubMed PMID: 13265318. 18: SEREMBE M. [Cyanacetic acid hydrazide associated with dihydrostreptomycin in the treatment of pulmonary tuberculosis]. Minerva Med. 1957 Sep 15;48(74):2931-5. Italian. PubMed PMID: 13483308. 19: GABUS P, GAUDIN P. [Clinical experimentation with cyanoacetic acid hydrazide of reazide in sanatorial treatment]. Rev Tuberc. 1956 May;20(5):528-40. French. PubMed PMID: 13371174. 20: El-Hawash SA, Abdel Wahab AE, El-Demellawy MA. Cyanoacetic acid hydrazones of 3-(and 4-)acetylpyridine and some derived ring systems as potential antitumor and anti-HCV agents. Arch Pharm (Weinheim). 2006 Jan;339(1):14-23. PubMed PMID: 16411172.