IHVR-11029 | CAS#1383152-30-4

MedKoo Cat#: 530475 | Name: IHVR-11029

Description:

WARNING: This product is for research use only, not for human or veterinary use.

IHVR-11029 is a potent ER α-glucosidase inhibitor. IHVR-11029 is active against multiple hemorrhagic fever viruses. IHVR-11029 efficiently disrupts the morphogenesis of a broad spectrum of enveloped viruses.

Chemical Structure

IHVR-11029

CAS#1383152-30-4

Theoretical Analysis

MedKoo Cat#: 530475

Name: IHVR-11029

CAS#: 1383152-30-4

Chemical Formula: C18H27F2NO5

Exact Mass: 375.1857

Molecular Weight: 375.41

Elemental Analysis: C, 57.59; H, 7.25; F, 10.12; N, 3.73; O, 21.31

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

IHVR-11029; IHVR 11029; IHVR11029.

IUPAC/Chemical Name

(2R,3R,4R,5S)-1-(6-(2,5-difluorophenoxy)hexyl)-2-(hydroxymethyl)piperidine-3,4,5-triol

InChi Key

XGCVJVFPIXDHPA-CYGHRXIMSA-N

InChi Code

InChI=1S/C18H27F2NO5/c19-12-5-6-13(20)16(9-12)26-8-4-2-1-3-7-21-10-15(23)18(25)17(24)14(21)11-22/h5-6,9,14-15,17-18,22-25H,1-4,7-8,10-11H2/t14-,15+,17-,18-/m1/s1

SMILES Code

OC[C@@H]1[C@H]([C@@H]([C@H](CN1CCCCCCOC2=CC(F)=CC=C2F)O)O)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 375.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zhao X, Guo F, Comunale MA, Mehta A, Sehgal M, Jain P, Cuconati A, Lin H, Block TM, Chang J, Guo JT. Inhibition of endoplasmic reticulum-resident glucosidases impairs severe acute respiratory syndrome coronavirus and human coronavirus NL63 spike protein-mediated entry by altering the glycan processing of angiotensin I-converting enzyme 2. Antimicrob Agents Chemother. 2015 Jan;59(1):206-16. doi: 10.1128/AAC.03999-14. PubMed PMID: 25348530; PubMed Central PMCID: PMC4291352. 2: Chang J, Warren TK, Zhao X, Gill T, Guo F, Wang L, Comunale MA, Du Y, Alonzi DS, Yu W, Ye H, Liu F, Guo JT, Mehta A, Cuconati A, Butters TD, Bavari S, Xu X, Block TM. Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses. Antiviral Res. 2013 Jun;98(3):432-40. doi: 10.1016/j.antiviral.2013.03.023. PubMed PMID: 23578725; PubMed Central PMCID: PMC3663898.