GSK-945237 | CAS#944406-54-6 | 944405-82-7 | topoisomerase inhibitor

MedKoo Cat#: 522992 | Name: GSK945237

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK945237 is a potent inhibitor of bacterial type IIA topoisomerases. GSK945237 shows good Gram-positive and Gram-negative potency and demonstrates good PK and in vivo efficacy properties.

Chemical Structure

GSK945237

CAS#944406-54-6 (free base)

Theoretical Analysis

MedKoo Cat#: 522992

Name: GSK945237

CAS#: 944406-54-6 (free base)

Chemical Formula: C24H26FN5O3

Exact Mass: 451.2020

Molecular Weight: 451.50

Elemental Analysis: C, 63.85; H, 5.80; F, 4.21; N, 15.51; O, 10.63

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

944405-82-7 (2HCl) 944406-54-6 (free base) 944406-55-7 (HCl) 1233947-19-7 (fumarate)

Synonym

GSK-945237; GSK 945237; GSK945237.

IUPAC/Chemical Name

(R)-1-((4-(((6,7-dihydro-[1,4]dioxino[2,3-c]pyridazin-3-yl)methyl)amino)piperidin-1-yl)methyl)-9-fluoro-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one

InChi Key

SRICOHRDRMZREQ-MRXNPFEDSA-N

InChi Code

InChI=1S/C24H26FN5O3/c25-19-3-1-15-2-4-21(31)30-14-16(22(19)23(15)30)13-29-7-5-17(6-8-29)26-12-18-11-20-24(28-27-18)33-10-9-32-20/h1-4,11,16-17,26H,5-10,12-14H2/t16-/m1/s1

SMILES Code

O=C1N2C3=C([C@H](CN4CCC(NCC5=NN=C(OCCO6)C6=C5)CC4)C2)C(F)=CC=C3C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Other CAS#944405-82-7 (GSK945237 2HCl); 944406-55-7 (GSK945237 HCl);

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 451.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Miles TJ, Hennessy AJ, Bax B, Brooks G, Brown BS, Brown P, Cailleau N, Chen D, Dabbs S, Davies DT, Esken JM, Giordano I, Hoover JL, Jones GE, Kusalakumari Sukmar SK, Markwell RE, Minthorn EA, Rittenhouse S, Gwynn MN, Pearson ND. Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases. Bioorg Med Chem Lett. 2016 Mar 31. pii: S0960-894X(16)30338-9. doi: 10.1016/j.bmcl.2016.03.106. [Epub ahead of print] PubMed PMID: 27055939.