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MedKoo Cat#: 584668 | Name: Majonoside R2

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Majonoside R2 is a major saponin constituent of Vietnamese ginseng.

Chemical Structure

Majonoside R2
Majonoside R2
CAS#81534-63-6

Theoretical Analysis

MedKoo Cat#: 584668

Name: Majonoside R2

CAS#: 81534-63-6

Chemical Formula: C41H70O14

Exact Mass: 786.4766

Molecular Weight: 787.00

Elemental Analysis: C, 62.57; H, 8.97; O, 28.46

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Majonoside R2; Majonoside R 2
IUPAC/Chemical Name
beta-D-Glucopyranoside, (3beta,6alpha,12beta,24S)-20,24-epoxy-3,12,25-trihydroxydammaran-6-yl 2-O-beta-D-xylopyranosyl-
InChi Key
UGMDQWNVJMIQKD-INCULIJBSA-N
InChi Code
InChI=1S/C41H70O14/c1-36(2)25(45)10-12-38(5)24-15-20(43)27-19(41(8)14-11-26(55-41)37(3,4)50)9-13-39(27,6)40(24,7)16-22(33(36)38)52-35-32(30(48)29(47)23(17-42)53-35)54-34-31(49)28(46)21(44)18-51-34/h19-35,42-50H,9-18H2,1-8H3/t19-,20-,21+,22+,23+,24+,25+,26-,27-,28-,29+,30-,31+,32+,33?,34-,35+,38+,39+,40+,41-/m0/s1
SMILES Code
O[C@@H]([C@@H]([C@@H](CO)O1)O)[C@@H](O[C@H]2[C@@H]([C@H]([C@@H](CO2)O)O)O)[C@@H]1O[C@H]3C4C(C)(C)[C@H](O)CC[C@]4(C)[C@@]5([H])C[C@H](O)[C@]6([H])[C@@H]([C@@](C)(O7)CC[C@H]7C(C)(O)C)CC[C@](C)6[C@@](C)5C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 787.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lee SY, Jeong JJ, Le TH, Eun SH, Nguyen MD, Park JH, Kim DH. Ocotillol, a Majonoside R2 Metabolite, Ameliorates 2,4,6-Trinitrobenzenesulfonic Acid-Induced Colitis in Mice by Restoring the Balance of Th17/Treg Cells. J Agric Food Chem. 2015 Aug 12;63(31):7024-31. doi: 10.1021/acs.jafc.5b02183. Epub 2015 Jul 30. PubMed PMID: 26194345. 2: Nguyen TT, Matsumoto K, Yamasaki K, Watanabe H. Involvement of supraspinal GABA receptors in majonoside-R2 suppression of clonidine-induced antinociception in mice. Life Sci. 1997;61(4):427-36. PubMed PMID: 9244369. 3: Jeong JJ, Van Le TH, Lee SY, Eun SH, Nguyen MD, Park JH, Kim DH. Anti-inflammatory effects of vina-ginsenoside R2 and majonoside R2 isolated from Panax vietnamensis and their metabolites in lipopolysaccharide-stimulated macrophages. Int Immunopharmacol. 2015 Sep;28(1):700-6. doi: 10.1016/j.intimp.2015.07.025. Epub 2015 Aug 5. PubMed PMID: 26256699. 4: Huong NT, Matsumoto K, Yamasaki K, Duc NM, Nham NT, Watanabe H. Majonoside-R2, a major constituent of Vietnamese ginseng, attenuates opioid-induced antinociception. Pharmacol Biochem Behav. 1997 May-Jun;57(1-2):285-91. PubMed PMID: 9164584. 5: Huong NT, Matsumoto K, Watanabe H. The antistress effect of majonoside-R2, a major saponin component of Vietnamese ginseng: neuronal mechanisms of action. Methods Find Exp Clin Pharmacol. 1998 Jan-Feb;20(1):65-76. Review. PubMed PMID: 9575485. 6: Huong NT, Murakami Y, Tohda M, Watanabe H, Matsumoto K. Social isolation stress-induced oxidative damage in mouse brain and its modulation by majonoside-R2, a Vietnamese ginseng saponin. Biol Pharm Bull. 2005 Aug;28(8):1389-93. PubMed PMID: 16079480. 7: Nguyen TT, Matsumoto K, Yamasaki K, Nguyen MD, Nguyen TN, Watanabe H. The possible involvement of GABAA systems in the antinarcotic effect of majonoside-R2, a major constituent of Vietnamese ginseng, in mice. Jpn J Pharmacol. 1996 Aug;71(4):345-9. PubMed PMID: 8886934. 8: Konoshima T, Takasaki M, Ichiishi E, Murakami T, Tokuda H, Nishino H, Duc NM, Kasai R, Yamasaki K. Cancer chemopreventive activity of majonoside-R2 from Vietnamese ginseng, Panax vietnamensis. Cancer Lett. 1999 Dec 1;147(1-2):11-6. PubMed PMID: 10660083. 9: Tran QL, Adnyana IK, Tezuka Y, Harimaya Y, Saiki I, Kurashige Y, Tran QK, Kadota S. Hepatoprotective effect of majonoside R2, the major saponin from Vietnamese ginseng (Panax vietnamensis). Planta Med. 2002 May;68(5):402-6. PubMed PMID: 12058314. 10: Nguyen TT, Matsumoto K, Yamasaki K, Nguyen MD, Nguyen TN, Watanabe H. Crude saponin extracted from Vietnamese ginseng and its major constituent majonoside-R2 attenuate the psychological stress- and foot-shock stress-induced antinociception in mice. Pharmacol Biochem Behav. 1995 Oct;52(2):427-32. PubMed PMID: 8577811. 11: Nguyen TT, Matsumoto K, Yamasaki K, Watanabe H. Majonoside-R2 reverses social isolation stress-induced decrease in pentobarbital sleep in mice: possible involvement of neuroactive steroids. Life Sci. 1997;61(4):395-402. PubMed PMID: 9244365. 12: Kim OT, Le MD, Trinh HX, Nong HV. In silico studies for the interaction of tumor necrosis factor-alpha (TNF-α) with different saponins from Vietnamese ginseng (Panax vietnamesis). Biophys Physicobiol. 2016 Jul 14;13:173-180. eCollection 2016. PubMed PMID: 27924272; PubMed Central PMCID: PMC5042174. 13: Konoshima T, Takasaki M, Tokuda H, Nishino H, Duc NM, Kasai R, Yamasaki K. Anti-tumor-promoting activity of majonoside-R2 from Vietnamese ginseng, Panax vietnamensis Ha et Grushv. (I). Biol Pharm Bull. 1998 Aug;21(8):834-8. PubMed PMID: 9743252. 14: Nguyen TT, Matsumoto K, Yamasaki K, Nguyen MD, Nguyen TN, Watanabe H. Effects of majonoside-R2 on pentobarbital sleep and gastric lesion in psychologically stressed mice. Pharmacol Biochem Behav. 1996 Apr;53(4):957-63. PubMed PMID: 8801603. 15: Yobimoto K, Matsumoto K, Huong NT, Kasai R, Yamasaki K, Watanabe H. Suppressive effects of vietnamese ginseng saponin and its major component majonoside-R2 on psychological stress-induced enhancement of lipid peroxidation in the mouse brain. Pharmacol Biochem Behav. 2000 Jul;66(3):661-5. PubMed PMID: 10899385. 16: Huong NT, Matsumoto K, Yamasaki K, Duc NM, Nham NT, Watanabe H. Effects of vietnamese ginseng on opioid agonist - and conditioned fear stress-induced antinociception. Phytomedicine. 1996 May;3(1):33-9. doi: 10.1016/S0944-7113(96)80007-9. PubMed PMID: 23194858. 17: Huong NT, Matsumoto K, Nham NT, Quang NH, Duc NM, Yamasaki K, Watanabe H. Effect of Vietnamese Ginseng on the phagocytosis in vitro and in vivo. Phytomedicine. 1997 Dec;4(4):341-6. doi: 10.1016/S0944-7113(97)80044-X. PubMed PMID: 23195585. 18: Nguyen MD, Nguyen TN, Kasai R, Ito A, Yamasaki K, Tanaka O. Saponins from Vietnamese ginseng, Panax vietnamensis Ha et Grushv. Collected in central Vietnam. I. Chem Pharm Bull (Tokyo). 1993 Nov;41(11):2010-4. PubMed PMID: 8293525. 19: Yamasaki K. Bioactive saponins in vietnamese ginseng, panax vietnamensis. Pharm Biol. 2000;38 Suppl 1:16-24. doi: 10.1076/phbi.38.6.16.5956. PubMed PMID: 23531134. 20: Zhang GH, Ma CH, Zhang JJ, Chen JW, Tang QY, He MH, Xu XZ, Jiang NH, Yang SC. Transcriptome analysis of Panax vietnamensis var. fuscidicus discovers putative ocotillol-type ginsenosides biosynthesis genes and genetic markers. BMC Genomics. 2015 Mar 8;16:159. doi: 10.1186/s12864-015-1332-8. PubMed PMID: 25765814; PubMed Central PMCID: PMC4355973.

View History

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