Trolline, also known as Oleracein E and (±)-Trolline, is a a tetrahydroisoquinoline possessing potent antioxidant activity. Trolline possesses various forms of pharmacological activity, including antibacterial and antiviral potency. Trolline significantly alleviated CCl4-induced liver injury and notably reduced the accumulation of collagen in liver tissues. Trolline treatment also markedly decreased inflammatory cytokines levels by inhibiting the NF-κB pathway. Trolline strongly inhibited HSC-T6 activation and notably induced cell apoptosis by modulating the Bax/Bcl-2 ratio, caspase activity, and MMP. Moreover, trolline significantly inhibited HSC-T6 autophagy.
MedKoo Cat#: 561010
Name: Trolline
CAS#: 1021950-79-7
Chemical Formula: C12H13NO3
Exact Mass: 219.0895
Molecular Weight: 219.24
Elemental Analysis: C, 65.74; H, 5.98; N, 6.39; O, 21.89
The following data is based on the product molecular weight 219.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
