MedKoo Cat#: 463028 | Name: Candidin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Candidin is a suspension of killed yeast cells. It is commonly used for intradermal tests of delayed hypersensitivity to evaluate the immunological cellular competence of the patient when the test is applied along with other similar tests.

Chemical Structure

Candidin
Candidin
CAS#1405-90-9

Theoretical Analysis

MedKoo Cat#: 463028

Name: Candidin

CAS#: 1405-90-9

Chemical Formula: C47H71NO17

Exact Mass: 921.4722

Molecular Weight: 922.08

Elemental Analysis: C, 61.22; H, 7.76; N, 1.52; O, 29.50

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Candidine;
IUPAC/Chemical Name
(1S,3R,4R,9S,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-(((2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-1,3,4,9,11,17,37-heptahydroxy-15,16,18-trimethyl-7,13-dioxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
InChi Key
IBRQTOKMQLIMRF-KACBBQTFSA-N
InChi Code
InChI=1S/C47H71NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-30,32-38,40-44,46,50-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,32+,33+,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1
SMILES Code
C[C@@H]1OC(C[C@@H](C[C@@H](CC(CC[C@H]([C@@H](C[C@@]2(C[C@@H]([C@@H](C(O)=O)[C@@H](O2)C[C@H](/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H]([C@H]([C@H]1C)O)C)O[C@@H]3O[C@@H]([C@H]([C@@H]([C@@H]3O)N)O)C)O)O)O)O)=O)O)O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 922.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Extractos dializados de leucocitos para el tratamiento de infecciones recurrentes y severas en pacientes pediátricos con inmunodeficiencia celular: 15 años de experiencia [Dialyzed leukocyte extracts for the treatment of recurrent and severe infections in pediatric patients with cellular immunodeficiency: 15 years of experience]. Rev Alerg Mex. 2019 Jan-Mar;66(1):27-37. Spanish. doi: 10.29262/ram.v66i1.531. PMID: 31013404. 4: Campos VC, Barrios MR, Salvatori R, de Almeida RP, de Melo EV, Nascimento AC, de Jesus AR, Aguiar-Oliveira MH. Infectious diseases and immunological responses in adult subjects with lifetime untreated, congenital GH deficiency. Endocrine. 2016 Oct;54(1):182-190. doi: 10.1007/s12020-016-1061-z. Epub 2016 Aug 3. PMID: 27484773. 5: Boiteau JG, Arlabosse JM, Aurelly M, Ghilini AL, Cardinaud I. Unambiguous (Z)-geometry and complete 1H and 13C assignments of candidine. Magn Reson Chem. 2015 Jun;53(6):476-8. doi: 10.1002/mrc.4211. Epub 2015 Apr 27. PMID: 25916498. 6: Moreno Amor AL, Santos LN, Alcântara Galvão A, Medeiros de Andrade Belitardo EM, Santos Silva E, Alcântara-Neves NM, Pontes-de-Carvalho L. Candidin and trichophytin stimulate the production of Th1 and regulatory cytokines by peripheral blood mononuclear cells: implication for their use as adjuvants in immunotherapy. Immunotherapy. 2014;6(12):1255-64. doi: 10.2217/imt.14.89. PMID: 25524382. 7: Segovia-Gamboa N, Rodríguez-Arellano ME, Rangel-Cruz R, Sánchez-Díaz M, Ramírez-Reyes JC, Faradji R, González-Domínguez É, Sánchez-Torres C. Tolerogenic dendritic cells induce antigen-specific hyporesponsiveness in insulin- and glutamic acid decarboxylase 65-autoreactive T lymphocytes from type 1 diabetic patients. Clin Immunol. 2014 Sep;154(1):72-83. doi: 10.1016/j.clim.2014.06.009. Epub 2014 Jun 30. PMID: 24993292. 8: Torres-Aguilar H, Blank M, Kivity S, Misgav M, Luboshitz J, Pierangeli SS, Shoenfeld Y. Tolerogenic dendritic cells inhibit antiphospholipid syndrome derived effector/memory CD4⁺ T cell response to β2GPI. Ann Rheum Dis. 2012 Jan;71(1):120-8. doi: 10.1136/annrheumdis-2011-200063. Epub 2011 Sep 12. PMID: 21914629. 9: Costa NM, Albuquerque Md, Lins JB, Alvares-Junior JT, Stefani MM. Delayed- type hypersensitivity skin test responses to PPD and other antigens among BCG- vaccinated HIV-1-infected and healthy children and adolescents. Rev Soc Bras Med Trop. 2011 Oct;44(5):542-5. doi: 10.1590/s0037-86822011005000054. Epub 2011 Aug 26. PMID: 21877065. 10: Torres-Aguilar H, Sánchez-Torres C, Jara LJ, Blank M, Shoenfeld Y. IL-10/TGF-beta-treated dendritic cells, pulsed with insulin, specifically reduce the response to insulin of CD4+ effector/memory T cells from type 1 diabetic individuals. J Clin Immunol. 2010 Sep;30(5):659-68. doi: 10.1007/s10875-010-9430-5. Epub 2010 Jun 11. PMID: 20544263. 11: Gardin NE. Immunological response to mistletoe (Viscum album L.) in cancer patients: a four-case series. Phytother Res. 2009 Mar;23(3):407-11. doi: 10.1002/ptr.2643. PMID: 19003944. 12: García de Acevedo B, Villa A, Hernández-Hernández F, López-Martínez R, Llorente L, Orozco-Topete R. Tiñas multifocales y localizadas en pacientes inmunosuprimidos [Multicentric and localized tineas in immunocompromised patients]. Rev Iberoam Micol. 2008 Mar;25(1):32-6. Spanish. doi: 10.1016/s1130-1406(08)70008-1. PMID: 18338925. 13: Hougardy JM, Place S, Hildebrand M, Drowart A, Debrie AS, Locht C, Mascart F. Regulatory T cells depress immune responses to protective antigens in active tuberculosis. Am J Respir Crit Care Med. 2007 Aug 15;176(4):409-16. doi: 10.1164/rccm.200701-084OC. Epub 2007 May 31. PMID: 17541018. 14: Olah I, Fukumori LM, Montanheiro P, Vergara MP, Smid J, Duarte AJ, Penalva de Oliveira AC, Casseb J. Patterns of in vitro lymphoproliferative responses among HTLV-1-infected subjects: upregulation by HTLV-1 during HIV-1 co- infection. Scand J Immunol. 2007 Jun;65(6):577-80. doi: 10.1111/j.1365-3083.2007.01941.x. PMID: 17523951. 15: Rosenberg EW, Skinner RB Jr. Immunotherapy of alopecia areata with intralesional Candida antigen. Pediatr Dermatol. 2006 May-Jun;23(3):299. doi: 10.1111/j.1525-1470.2006.00240.x. PMID: 16780487. 16: Benveniste O, Flahault A, Rollot F, Elbim C, Estaquier J, Pédron B, Duval X, Dereuddre-Bosquet N, Clayette P, Sterkers G, Simon A, Ameisen JC, Leport C. Mechanisms involved in the low-level regeneration of CD4+ cells in HIV-1-infected patients receiving highly active antiretroviral therapy who have prolonged undetectable plasma viral loads. J Infect Dis. 2005 May 15;191(10):1670-9. doi: 10.1086/429670. Epub 2005 Apr 5. PMID: 15838794. 17: Méndez-Tovar LJ, Mondragón-González R, Vega-López F, Dockrell HM, Hay R, López-Martínez R, Manzano-Gayosso P, Hernández-Hernández F, Padilla-Desgarennes C, Bonifaz A. Cytokine production and lymphocyte proliferation in patients with Nocardia brasiliensis actinomycetoma. Mycopathologia. 2004 Nov;158(4):407-14. doi: 10.1007/s11046-004-3126-4. PMID: 15630549. 18: Kadota I, Hu Y, Packard GK, Rychnovsky SD. A unified approach to polyene macrolides: synthesis of candidin and nystatin polyols. Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):11992-5. doi: 10.1073/pnas.0401552101. Epub 2004 Jun 10. PMID: 15192147; PMCID: PMC514422. 19: Arzumanyan VG, Serdyuk OA, Kozlova NN, Basnak'yan IA, Fedoseeva VN. IgE and IgG antibodies to Malassezia spp. yeast extract in patients with atopic dermatitis. Bull Exp Biol Med. 2003 May;135(5):460-3. doi: 10.1023/a:1024967426025. PMID: 12910286. 20: Benzarti M, Mezghani S, Jarray M, Garrouche A, Khirouni S, Klabi N. 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