HS56 | CAS# 922050-57-5 | Pim/DAPK3 Inhibitor

MedKoo Cat#: 565175 | Name: HS56

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HS56 is an ATP-competitive dual Pim/DAPK3 inhibitor which reduces Pim kinase-induced myosin phosphorylation and the contractility of vascular smooth muscle in spontaneously hypertensive RenTG mice.

Chemical Structure

HS56

CAS#922050-57-5

Theoretical Analysis

MedKoo Cat#: 565175

Name: HS56

CAS#: 922050-57-5

Chemical Formula: C13H8ClN5OS

Exact Mass: 317.0138

Molecular Weight: 317.75

Elemental Analysis: C, 49.14; H, 2.54; Cl, 11.16; N, 22.04; O, 5.04; S, 10.09

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

HS56; HS-56; HS 56

IUPAC/Chemical Name

2-((1-(3-Chlorophenyl)-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)thio)acetonitrile

InChi Key

DRTDDTWOOFJKOH-UHFFFAOYSA-N

InChi Code

InChI=1S/C13H8ClN5OS/c14-8-2-1-3-9(6-8)19-11-10(7-16-19)12(20)18-13(17-11)21-5-4-15/h1-3,6-7H,5H2,(H,17,18,20)

SMILES Code

N#CCSC1=NC(N(C2=CC=CC(Cl)=C2)N=C3)=C3C(N1)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 317.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Carlson DA, Singer MR, Sutherland C, Redondo C, Alexander LT, Hughes PF, Knapp S, Gurley SB, Sparks MA, MacDonald JA, Haystead TAJ. Targeting Pim Kinases and DAPK3 to Control Hypertension. Cell Chem Biol. 2018 Oct 18;25(10):1195-1207.e32. doi: 10.1016/j.chembiol.2018.06.006. Epub 2018 Jul 19. PubMed PMID: 30033129.