Synonym
2-AEMP TFA; 2AEMP TFA; 2 AEMP TFA; 2-AEMP; 2 AEMP; 2AEMP
IUPAC/Chemical Name
2-Aminoethyl methylphosphonate trifluoroacetate salt
InChi Key
RFQBFVSSBOQLIQ-UHFFFAOYSA-M
InChi Code
InChI=1S/C3H10NO3P.C2HF3O2/c1-8(5,6)7-3-2-4;3-2(4,5)1(6)7/h2-4H2,1H3,(H,5,6);(H,6,7)/p-1
SMILES Code
CP(OCCN)([O-])=O.O=C(O)C(F)(F)F
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
252.11
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Xie A, Yan J, Yue L, Feng F, Mir F, Abdel-Halim H, Chebib M, Le Breton GC, Standaert RF, Qian H, Pepperberg DR. 2-Aminoethyl methylphosphonate, a potent and rapidly acting antagonist of GABA(A)-ρ1 receptors. Mol Pharmacol. 2011 Dec;80(6):965-78. doi: 10.1124/mol.111.071225. Epub 2011 Aug 2. PubMed PMID: 21810922; PubMed Central PMCID: PMC3228531.
2: Wang J, Mojumder DK, Yan J, Xie A, Standaert RF, Qian H, Pepperberg DR, Frishman LJ. In vivo electroretinographic studies of the role of GABAC receptors in retinal signal processing. Exp Eye Res. 2015 Oct;139:48-63. doi: 10.1016/j.exer.2015.07.002. Epub 2015 Jul 8. PubMed PMID: 26164072; PubMed Central PMCID: PMC4573340.
