MedKoo Cat#: 526175 | Name: Ro 24-0238

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ro 24-0238 is a platelet-activating factor-antagonist. It is one of the most potent lipid mediators in allergic and inflammatory reactions.

Chemical Structure

Ro 24-0238
Ro 24-0238
CAS#120555-31-9

Theoretical Analysis

MedKoo Cat#: 526175

Name: Ro 24-0238

CAS#: 120555-31-9

Chemical Formula: C27H36N2O2

Exact Mass: 420.2777

Molecular Weight: 420.60

Elemental Analysis: C, 77.10; H, 8.63; N, 6.66; O, 7.61

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Ro 24-0238; Ro 24 0238; Ro-24-0238.
IUPAC/Chemical Name
(R-(E,E))-5-(4-Methoxyphenyl)-N-(1-methyl-4-(3-pyridinyl)butyl)-2,4-decadienamide
InChi Key
HLCHRSFXEXAMLU-YDQNRGGDSA-N
InChi Code
InChI=1S/C27H36N2O2/c1-4-5-6-13-24(25-16-18-26(31-3)19-17-25)14-8-15-27(30)29-22(2)10-7-11-23-12-9-20-28-21-23/h8-9,12,14-22H,4-7,10-11,13H2,1-3H3,(H,29,30)/b15-8+,24-14+/t22-/m1/s1
SMILES Code
CCCCC/C(C1=CC=C(OC)C=C1)=C\C=C\C(N[C@H](C)CCCC2=CC=CN=C2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 420.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Erickson KL, Howard AD, Hubbard NE. Induction and modulation of macrophage Ia antigen expression by platelet-activating factor. J Leukoc Biol. 1997 Dec;62(6):845-51. PubMed PMID: 9400826. 2: Negro Alvarez JM, Miralles López JC, Ortiz Martínez JL, Abellán Alemán A, Rubio del Barrio R. Platelet-activating factor antagonists. Allergol Immunopathol (Madr). 1997 Sep-Oct;25(5):249-58. Review. PubMed PMID: 9395010. 3: Abeck D, Andersson T, Grosshans E, Jablonska S, Kragballe K, Vahlquist A, Schmidt T, Dupuy P, Ring J. Topical application of a platelet-activating factor (PAF) antagonist in atopic dermatitis. Acta Derm Venereol. 1997 Nov;77(6):449-51. PubMed PMID: 9394979. 4: Elbers ME, Gerritsen MJ, van de Kerkhof PC. The effect of topical application of the platelet-activating factor-antagonist, Ro 24-0238, in psoriasis vulgaris--a clinical and immunohistochemical study. Clin Exp Dermatol. 1994 Nov;19(6):453-7. PubMed PMID: 7889665. 5: Coffen DL, Okabe M, Sun RC, Lee S, Matcham GW. Aminotransferase catalysis applied to the synthesis of a PAF antagonist. Bioorg Med Chem. 1994 Jun;2(6):411-3. PubMed PMID: 8000861. 6: Wang KA, Blain RW, Szuna AJ. Multidimensional narrow bore liquid chromatography analysis of Ro 24-0238 in human plasma. J Pharm Biomed Anal. 1994 Jan;12(1):105-10. PubMed PMID: 8161596. 7: Will PC, Thomas TK, Iverson L, Buckman D, Weis W, Wilson C, Srivastava A. Platelet activating factor as a proinflammatory mediator in acetic-induced colitis in the rat. Agents Actions. 1991 Sep;34(1-2):181-4. PubMed PMID: 1793026.