MedKoo Cat#: 564807 | Name: UK-59811 HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

UK-59811 HCl is a calcium channel blocker which inhibits CaVAb and binds at the outer, lipid-facing surface of the pore at the interface between two CaVAb subunits.

Chemical Structure

UK-59811 HCl
UK-59811 HCl
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564807

Name: UK-59811 HCl

CAS#: NONE

Chemical Formula: C22H30BrClN2O5

Exact Mass:

Molecular Weight: 517.85

Elemental Analysis: C, 51.03; H, 5.84; Br, 15.43; Cl, 6.85; N, 5.41; O, 15.45

Price and Availability

Size Price Availability Quantity
5mg USD 280.00 2 Weeks
25mg USD 750.00 2 Weeks
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Related CAS #
No Data
Synonym
UK59811 HCl; UK 59811 HCl; UK-59811 HCl; UK-59811 hydrochloride
IUPAC/Chemical Name
3-Ethyl 5-methyl 4-(2-bromophenyl)-2-((2-(dimethylamino)ethoxy)methyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride
InChi Key
JZOQTVYILXBAMQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H29BrN2O5.ClH/c1-6-30-22(27)20-17(13-29-12-11-25(3)4)24-14(2)18(21(26)28-5)19(20)15-9-7-8-10-16(15)23;/h7-10,19,24H,6,11-13H2,1-5H3;1H
SMILES Code
O=C(C1=C(COCCN(C)C)NC(C)=C(C(OC)=O)C1C2=CC=CC=C2Br)OCC.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 517.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tang L, Gamal El-Din TM, Swanson TM, Pryde DC, Scheuer T, Zheng N, Catterall WA. Structural basis for inhibition of a voltage-gated Ca(2+) channel by Ca(2+) antagonist drugs. Nature. 2016 Sep 1;537(7618):117-121. doi: 10.1038/nature19102. Epub 2016 Aug 24. PubMed PMID: 27556947; PubMed Central PMCID: PMC5161592.