Synonym
2'-O-Methyluridine; 2140-76-3; Uridine, 2'-O-methyl-; O(2')-Methyluridine
IUPAC/Chemical Name
1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
InChi Key
SXUXMRMBWZCMEN-ZOQUXTDFSA-N
InChi Code
InChI=1S/C10H14N2O6/c1-17-8-7(15)5(4-13)18-9(8)12-3-2-6(14)11-10(12)16/h2-3,5,7-9,13,15H,4H2,1H3,(H,11,14,16)/t5-,7-,8-,9-/m1/s1
SMILES Code
O=C1NC(C=CN1[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2OC)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
258.23
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Aučynaitė A, Rutkienė R, Tauraitė D, Meškys R, Urbonavičius J. Identification
of a 2'-O-Methyluridine Nucleoside Hydrolase Using the Metagenomic
Libraries. Molecules. 2018 Nov 7;23(11):2904. doi: 10.3390/molecules23112904.
PMID: 30405065; PMCID: PMC6278475.
2: Furukawa Y, Kobayashi K, Kanai Y, Honjo M. Synthesis of 2'-O-methyluridine,
2'-O-methylcytidine and their relating compounds. Chem Pharm Bull (Tokyo). 1965
Nov;13(11):1273-8. doi: 10.1248/cpb.13.1273. PMID: 5864715.
3: al-Arif A, Sporn MB. 2'-O-methylation of adenosine, guanosine, uridine, and
cytidine in RNA of isolated rat liver nuclei. Proc Natl Acad Sci U S A. 1972
Jul;69(7):1716-9. doi: 10.1073/pnas.69.7.1716. PMID: 4340155; PMCID: PMC426785.
4: Mitsukawa Y, Hibi M, Matsutani N, Horinouchi N, Takahashi S, Ogawa J. New
nucleoside hydrolase with transribosylation activity from Agromyces sp. MM-1 and
its application for enzymatic synthesis of 2'-O-methylribonucleosides. J Biosci
Bioeng. 2018 Jan;125(1):38-45. doi: 10.1016/j.jbiosc.2017.07.016. Epub 2017 Aug
18. PMID: 28826816.
