Synonym
2AAF, 2-AA-F, 2A-AF, 2-Acetylaminofluorene; N-2-Fluorenylacetamide
IUPAC/Chemical Name
N-2-Fluorenylacetamide
InChi Key
CZIHNRWJTSTCEX-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H13NO/c1-10(17)16-13-6-7-15-12(9-13)8-11-4-2-3-5-14(11)15/h2-7,9H,8H2,1H3,(H,16,17)
SMILES Code
CC(NC1=CC(CC2=C3C=CC=C2)=C3C=C1)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
223.23
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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5: Lin M, Sun P, Zhang G, Xu X, Liu G, Miao H, Yang Y, Xu H, Zhang L, Wu P, Li M. Vitamin K2-enhanced liver regeneration is associated with oval cell expansion and up-regulation of matrilin-2 expression in 2-AAF/PH rat model. Curr Mol Med. 2014 Mar;14(3):361-9. doi: 10.2174/1566524013666131118113017. PMID: 24236453.
6: Dayanidhi PD, Vaidyanathan VG. Understanding the ancillary ligand effect on luminescent cyclometalated Ir(III) complex as a reporter for 2-acetylaminofluorene DNA(AAF-dG) adduct. J Biol Inorg Chem. 2022 Feb;27(1):189-199. doi: 10.1007/s00775-021-01920-5. Epub 2021 Nov 29. PMID: 34843001.
7: Jenkins GJ, Parry JM. Restriction site mutation (RSM) analysis of 2-acetylaminofluorene (2-AAF)-induced mouse liver mutations and comparison with the measurement of in vivo micronucleus induction in the bone marrows of (2-AAF)-treated mice. Teratog Carcinog Mutagen. 2000;20(3):107-17. doi: 10.1002/(sici)1520-6866(2000)20:3<107::aid-tcm2>3.0.co;2-8. PMID: 10820421.
8: Hoogervorst EM, van Oostrom CT, Beems RB, van Benthem J, van den Berg J, van Kreijl CF, Vos JG, de Vries A, van Steeg H. 2-AAF-induced tumor development in nucleotide excision repair-deficient mice is associated with a defect in global genome repair but not with transcription coupled repair. DNA Repair (Amst). 2005 Jan 2;4(1):3-9. doi: 10.1016/j.dnarep.2004.08.009. PMID: 15533832.
9: 2-Acetylaminofluorene. Rep Carcinog. 2004;11:III3-4. PMID: 21089793.
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