Synonym
VK-28; VK 28; VK28;
IUPAC/Chemical Name
5-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)quinolin-8-ol
InChi Key
XIXFNVDWEWCEOI-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H21N3O2/c20-11-10-18-6-8-19(9-7-18)12-13-3-4-15(21)16-14(13)2-1-5-17-16/h1-5,20-21H,6-12H2
SMILES Code
OCCN1CCN(CC1)CC2=C3C=CC=NC3=C(C=C2)O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
287.36
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Li Q, Wan J, Lan X, Han X, Wang Z, Wang J. Neuroprotection of brain-permeable
iron chelator VK-28 against intracerebral hemorrhage in mice. J Cereb Blood Flow
Metab. 2017 Sep;37(9):3110-3123. doi: 10.1177/0271678X17709186. Epub 2017 May
23. PMID: 28534662; PMCID: PMC5584702.
2: Shachar DB, Kahana N, Kampel V, Warshawsky A, Youdim MB. Neuroprotection by a
novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lession in
rats. Neuropharmacology. 2004 Feb;46(2):254-63. doi:
10.1016/j.neuropharm.2003.09.005. PMID: 14680763.
3: Youdim MB, Fridkin M, Zheng H. Bifunctional drug derivatives of MAO-B
inhibitor rasagiline and iron chelator VK-28 as a more effective approach to
treatment of brain ageing and ageing neurodegenerative diseases. Mech Ageing
Dev. 2005 Feb;126(2):317-26. doi: 10.1016/j.mad.2004.08.023. PMID: 15621213.
4: Bandyopadhyay S, Huang X, Cho H, Greig NH, Youdim MB, Rogers JT. Metal
specificity of an iron-responsive element in Alzheimer's APP mRNA 5'untranslated
region, tolerance of SH-SY5Y and H4 neural cells to desferrioxamine, clioquinol,
VK-28, and a piperazine chelator. J Neural Transm Suppl. 2006;(71):237-47. doi:
10.1007/978-3-211-33328-0_25. PMID: 17447434.
5: Youdim MB, Stephenson G, Ben Shachar D. Ironing iron out in Parkinson's
disease and other neurodegenerative diseases with iron chelators: a lesson from
6-hydroxydopamine and iron chelators, desferal and VK-28. Ann N Y Acad Sci. 2004
Mar;1012:306-25. doi: 10.1196/annals.1306.025. PMID: 15105275.
