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MedKoo Cat#: 329672 | Name: Moroxydine HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Moroxydine is an antiviral agent. Moroxydine targets DNA and RNA viruses including measles, herpes simplex, varicella zoster, and hepatitis C, and formulations containing moroxydine are used to treat the symptoms of influenza virus strain A.

Chemical Structure

Moroxydine HCl
Moroxydine HCl
CAS#3160-91-6 (HCl)

Theoretical Analysis

MedKoo Cat#: 329672

Name: Moroxydine HCl

CAS#: 3160-91-6 (HCl)

Chemical Formula: C6H14ClN5O

Exact Mass: 0.0000

Molecular Weight: 207.66

Elemental Analysis: C, 34.70; H, 6.80; Cl, 17.07; N, 33.73; O, 7.70

Price and Availability

Size Price Availability Quantity
2g USD 90.00 Ready to ship
5g USD 150.00 Ready to ship
10g USD 250.00 Ready to ship
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Related CAS #
3160-91-6 (HCl) 3731-59-7 (free base)
Synonym
Moroxydine hydrochloride; Moroxydine HCl; ABOB hydrochloride; Flumidin; SKF 8898-A; SKF 8898A; NSC 407204; NSC 43840; NSC 47838; NSC 52355; NSC 63755.
IUPAC/Chemical Name
N-carbamimidoylmorpholine-4-carboximidamide hydrochloride
InChi Key
FXYZDFSNBBOHTA-UHFFFAOYSA-N
InChi Code
InChI=1S/C6H13N5O.ClH/c7-5(8)10-6(9)11-1-3-12-4-2-11;/h1-4H2,(H5,7,8,9,10);1H
SMILES Code
N=C(N1CCOCC1)NC(N)=N.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Certificate of Analysis
View CoA: current batch, Lot#A24M12B28
Safety Data Sheet (SDS)
View Safety Data Sheet (SDS)
Instruction
View handling instruction
Biological target:
Moroxydine hydrochloride (ABOB hydrochloride) is a synthetic antiviral compound chemically belonging to the series of the heterocyclic biguanidines.
In vitro activity:
The paper was undertaken to explore the antiviral response and antiapoptotic mechanism of Mor against grass carp reovirus (GCRV) in Ctenopharyngodon idella kidney (CIK) cells. Moroxydine blocked the GCRV-induced cytopathic effects and eliminated nucleocapsids in CIK cells to keep the normal morphological structure. The downstream effector, caspase activity was also significantly inhibited in Mor treated cells Reference: Antiviral Res. 2016 Jul;131:156-65. https://pubmed.ncbi.nlm.nih.gov/27188236/
In vivo activity:
TBD
Solvent mg/mL mM
Solubility
Water 71.0 341.90
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 207.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Yu XB, Chen XH, Ling F, Hao K, Wang GX, Zhu B. Moroxydine hydrochloride inhibits grass carp reovirus replication and suppresses apoptosis in Ctenopharyngodon idella kidney cells. Antiviral Res. 2016 Jul;131:156-65. doi: 10.1016/j.antiviral.2016.05.008. Epub 2016 May 14. PMID: 27188236.
In vitro protocol:
1. Yu XB, Chen XH, Ling F, Hao K, Wang GX, Zhu B. Moroxydine hydrochloride inhibits grass carp reovirus replication and suppresses apoptosis in Ctenopharyngodon idella kidney cells. Antiviral Res. 2016 Jul;131:156-65. doi: 10.1016/j.antiviral.2016.05.008. Epub 2016 May 14. PMID: 27188236.
In vivo protocol:
TBD
1: Yu XB, Chen XH, Shan LP, Hao K, Wang GX. In vitro antiviral efficacy of moroxydine hydrochloride and ribavirin against grass carp reovirus and giant salamander iridovirus. Dis Aquat Organ. 2016 Oct 27;121(3):189-199. PubMed PMID: 27786157. 2: Zhang Q, Xiao C, Wang W, Qian M, Xu J, Yang H. Chromatography column comparison and rapid pretreatment for the simultaneous analysis of amantadine, rimantadine, acyclovir, ribavirin, and moroxydine in chicken muscle by ultra high performance liquid chromatography and tandem mass spectrometry. J Sep Sci. 2016 Oct;39(20):3998-4010. doi: 10.1002/jssc.201600490. Epub 2016 Sep 28. PubMed PMID: 27568878. 3: Yu XB, Chen XH, Ling F, Hao K, Wang GX, Zhu B. Moroxydine hydrochloride inhibits grass carp reovirus replication and suppresses apoptosis in Ctenopharyngodon idella kidney cells. Antiviral Res. 2016 Jul;131:156-65. doi: 10.1016/j.antiviral.2016.05.008. Epub 2016 May 14. PubMed PMID: 27188236. 4: Mu P, Xu N, Chai T, Jia Q, Yin Z, Yang S, Qian Y, Qiu J. Simultaneous determination of 14 antiviral drugs and relevant metabolites in chicken muscle by UPLC-MS/MS after QuEChERS preparation. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jun 15;1023-1024:17-23. doi: 10.1016/j.jchromb.2016.04.036. Epub 2016 Apr 30. PubMed PMID: 27174693. 5: Sun WJ, Lv WJ, Li LN, Yin G, Hang X, Xue Y, Chen J, Shi Z. Eugenol confers resistance to Tomato yellow leaf curl virus (TYLCV) by regulating the expression of SlPer1 in tomato plants. N Biotechnol. 2016 May 25;33(3):345-54. doi: 10.1016/j.nbt.2016.01.001. Epub 2016 Jan 14. PubMed PMID: 26776605. 6: Liu W, Xu J, Zhou Y, Chen J, Ma J, Zeng L. Pharmacokinetics and tissue residues of moroxydine hydrochloride in gibel carp, Carassius gibelio after oral administration. J Vet Pharmacol Ther. 2016 Aug;39(4):398-404. doi: 10.1111/jvp.12289. Epub 2016 Jan 14. PubMed PMID: 26763124. 7: Magri A, Reilly R, Scalacci N, Radi M, Hunter M, Ripoll M, Patel AH, Castagnolo D. Rethinking the old antiviral drug moroxydine: Discovery of novel analogues as anti-hepatitis C virus (HCV) agents. Bioorg Med Chem Lett. 2015 Nov 15;25(22):5372-6. doi: 10.1016/j.bmcl.2015.09.029. Epub 2015 Sep 12. PubMed PMID: 26428870. 8: Liu Z, Yang F, Yao M, Lin Y, Su Z. Simultaneous determination of antiviral drugs in chicken tissues by ultra high performance liquid chromatography with tandem mass spectrometry. J Sep Sci. 2015 May;38(10):1784-93. doi: 10.1002/jssc.201401461. Epub 2015 May 6. PubMed PMID: 25781863. 9: Liu Z, Yang F, Yu K, Lin Y, Liu S, Zhang Q, Su Z. [Multi-residue determination of five antiviral drugs in chicken tissues by liquid chromatography-electrospray ionization tandem mass spectrometry]. Se Pu. 2012 Dec;30(12):1253-9. Chinese. PubMed PMID: 23593882. 10: Zhang X, Peng Y, Wan P, Yin L, Wang G, Sun J. Simultaneous determination and pharmacokinetic study of metformin and pioglitazone in dog plasma by LC-MS-MS. J Chromatogr Sci. 2014 Jan;52(1):52-8. doi: 10.1093/chromsci/bms204. Epub 2013 Jan 4. PubMed PMID: 23293039. 11: Lu L, Gao X, Zhu M, Wang S, Wu Q, Xing S, Fu X, Liu Z, Guo M. Exploration of biguanido-oxovanadium complexes as potent and selective inhibitors of protein tyrosine phosphatases. Biometals. 2012 Jun;25(3):599-610. doi: 10.1007/s10534-012-9548-4. Epub 2012 May 1. PubMed PMID: 22547055. 12: Wang X, Qiu H, Liu X, Jiang S. [Separation of bases, phenols and pharmaceuticals on ionic liquid-modified silica stationary phase with pure water as mobile phase]. Se Pu. 2011 Mar;29(3):269-72. Chinese. PubMed PMID: 21657060. 13: Fan J, Wei Y, Wang J, Wu C, Shi H. Study of molecularly imprinted solid-phase extraction of diphenylguanidine and its structural analogs. Anal Chim Acta. 2009 Apr 20;639(1-2):42-50. doi: 10.1016/j.aca.2009.02.045. Epub 2009 Mar 9. PubMed PMID: 19345756. 14: Zhou G, Han S, Shi Y, Sui H. [Inhibition of respiratory syncytial virus (RSV) by moroxydine, allicin, alpha-interferon and their joint application]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 1997 Sep;11(3):286-9. Chinese. PubMed PMID: 15617350. 15: Patrinoiu G, Patron L, Weinberg J, Nita S, Meghea A. Synthesis and molecular mechanical studies of antiviral copper(II) complexes with morpholinebiguanide drug. Roum Arch Microbiol Immunol. 1998 Jul-Dec;57(3-4):279-93. PubMed PMID: 11845440. 16: Topciu V, Mihăilescu R. Immunomodulating and antiviral therapy in herpes zoster. Rom J Virol. 1996 Jan-Dec;47(1-4):75-80. PubMed PMID: 9495784. 17: Gris JC, Neveu S, Tailland ML, Courtieu C, Marès P, Schved JF. Use of a low-molecular weight heparin (enoxaparin) or of a phenformin-like substance (moroxydine chloride) in primary early recurrent aborters with an impaired fibrinolytic capacity. Thromb Haemost. 1995 Mar;73(3):362-7. PubMed PMID: 7667816. 18: Sheppard S. Moroxydine: the story of a mislaid antiviral. Acta Derm Venereol Suppl (Stockh). 1994;183:1-9. Review. PubMed PMID: 9868507. 19: Topciu V, Chercotă G, Mihăilescu R, Nadolnic A. [Beneficial effects of immunostimulant and antiviral therapy of ophthalmic herpes zoster]. Rom J Virol. 1993 Jan-Jun;44(1-2):91-5. French. PubMed PMID: 9702254. 20: Topciu V, Fufezan I, Mihăilescu R, Stanciu N. [Immunochemical therapy of warts and growths due to papillomavirus]. Rom J Virol. 1993 Jan-Jun;44(1-2):85-90. French. PubMed PMID: 9702253.