MedKoo Cat#: 571383 | Name: Moroxydine free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Moroxydine free base is an antiviral drug previously used to treat influenza virus.

Chemical Structure

Moroxydine free base
Moroxydine free base
CAS#3731-59-7 (free base)

Theoretical Analysis

MedKoo Cat#: 571383

Name: Moroxydine free base

CAS#: 3731-59-7 (free base)

Chemical Formula: C6H13N5O

Exact Mass: 171.1120

Molecular Weight: 171.20

Elemental Analysis: C, 42.09; H, 7.65; N, 40.91; O, 9.34

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Moroxydine free base; Moroxydinum; Bimolin; Virugon; Virumin; Wirumin; SKF 8898-A; SKF 8898A; SKF-8898-A;
IUPAC/Chemical Name
4-Morpholinecarboximidoylguanidine
InChi Key
KJHOZAZQWVKILO-UHFFFAOYSA-N
InChi Code
1S/C6H13N5O/c7-5(8)10-6(9)11-1-3-12-4-2-11/h1-4H2,(H5,7,8,9,10)
SMILES Code
N1(C(=N)NC(N)=N)CCOCC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 171.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liu W, Xu J, Zhou Y, Chen J, Ma J, Zeng L. Pharmacokinetics and tissue residues of moroxydine hydrochloride in gibel carp, Carassius gibelio after oral administration. J Vet Pharmacol Ther. 2016 Aug;39(4):398-404. doi: 10.1111/jvp.12289. Epub 2016 Jan 14. PubMed PMID: 26763124. 2: Magri A, Reilly R, Scalacci N, Radi M, Hunter M, Ripoll M, Patel AH, Castagnolo D. Rethinking the old antiviral drug moroxydine: Discovery of novel analogues as anti-hepatitis C virus (HCV) agents. Bioorg Med Chem Lett. 2015 Nov 15;25(22):5372-6. doi: 10.1016/j.bmcl.2015.09.029. Epub 2015 Sep 12. PubMed PMID: 26428870. 3: Yu XB, Chen XH, Shan LP, Hao K, Wang GX. In vitro antiviral efficacy of moroxydine hydrochloride and ribavirin against grass carp reovirus and giant salamander iridovirus. Dis Aquat Organ. 2016 Oct 27;121(3):189-199. PubMed PMID: 27786157. 4: Yu XB, Chen XH, Ling F, Hao K, Wang GX, Zhu B. Moroxydine hydrochloride inhibits grass carp reovirus replication and suppresses apoptosis in Ctenopharyngodon idella kidney cells. Antiviral Res. 2016 Jul;131:156-65. doi: 10.1016/j.antiviral.2016.05.008. Epub 2016 May 14. PubMed PMID: 27188236. 5: Sheppard S. Moroxydine: the story of a mislaid antiviral. Acta Derm Venereol Suppl (Stockh). 1994;183:1-9. Review. PubMed PMID: 9868507. 6: Mertens T, Eggers HJ. [Moroxydine]. Dtsch Med Wochenschr. 1980 Feb 8;105(6):184. German. PubMed PMID: 7353484. 7: Zhou G, Han S, Shi Y, Sui H. [Inhibition of respiratory syncytial virus (RSV) by moroxydine, allicin, alpha-interferon and their joint application]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 1997 Sep;11(3):286-9. Chinese. PubMed PMID: 15617350. 8: Tengborn L, Hedner U, Nilsson IM. Prospective study of a phenformin-like substance (moroxydine chloride) in patients with deficient vessel wall fibrinolysis. J Med. 1982;13(5-6):353-64. PubMed PMID: 6963328. 9: Vessman J, Johansson M, Gröningsson K. Determination of moroxydine in biological fluids by electron-capture gas chromatography. J Chromatogr. 1982 Apr 16;229(1):227-33. PubMed PMID: 7085830. 10: Zhang Q, Xiao C, Wang W, Qian M, Xu J, Yang H. Chromatography column comparison and rapid pretreatment for the simultaneous analysis of amantadine, rimantadine, acyclovir, ribavirin, and moroxydine in chicken muscle by ultra high performance liquid chromatography and tandem mass spectrometry. J Sep Sci. 2016 Oct;39(20):3998-4010. doi: 10.1002/jssc.201600490. Epub 2016 Sep 28. PubMed PMID: 27568878. 11: Gris JC, Neveu S, Tailland ML, Courtieu C, Marès P, Schved JF. Use of a low-molecular weight heparin (enoxaparin) or of a phenformin-like substance (moroxydine chloride) in primary early recurrent aborters with an impaired fibrinolytic capacity. Thromb Haemost. 1995 Mar;73(3):362-7. PubMed PMID: 7667816. 12: Boberg M, Killander A. Failure of the biguanide moroxydine chloride to stimulate plasma fibrinolytic activity. Acta Med Scand. 1984;215(3):221-4. PubMed PMID: 6731035. 13: Grobe JW. [Virostatic effect in the treatment of pityriasis rosea irritata with moroxydine-HCI]. Derm Beruf Umwelt. 1984;32(1):25. German. PubMed PMID: 6705693. 14: Topciu V, Bratu D, Mihăilescu R, Borţun C. [Recurrent herpetic gingivostomatitis treated with moroxydine, antiherpin and the immunostimulant SRE]. Bacteriol Virusol Parazitol Epidemiol. 1992 Jul-Dec;37(3-4):65-7. Romanian. PubMed PMID: 1340264. 15: Sun WJ, Lv WJ, Li LN, Yin G, Hang X, Xue Y, Chen J, Shi Z. Eugenol confers resistance to Tomato yellow leaf curl virus (TYLCV) by regulating the expression of SlPer1 in tomato plants. N Biotechnol. 2016 May 25;33(3):345-54. doi: 10.1016/j.nbt.2016.01.001. Epub 2016 Jan 14. PubMed PMID: 26776605. 16: Zhang X, Peng Y, Wan P, Yin L, Wang G, Sun J. Simultaneous determination and pharmacokinetic study of metformin and pioglitazone in dog plasma by LC-MS-MS. J Chromatogr Sci. 2014 Jan;52(1):52-8. doi: 10.1093/chromsci/bms204. Epub 2013 Jan 4. PubMed PMID: 23293039. 17: Liu Z, Yang F, Yao M, Lin Y, Su Z. Simultaneous determination of antiviral drugs in chicken tissues by ultra high performance liquid chromatography with tandem mass spectrometry. J Sep Sci. 2015 May;38(10):1784-93. doi: 10.1002/jssc.201401461. Epub 2015 May 6. PubMed PMID: 25781863. 18: Lu RG. [Application of derivative spectrophotometric signal multiplier method in multicomponent mixture--determination of moroxydine hydrochloride in Gan Mao Qing capsules]. Yao Xue Xue Bao. 1992;27(11):871-4. Chinese. PubMed PMID: 1300034. 19: Dreyfus P. [Treatment of influenzal infections by a moroxydine derivative]. Sem Ther. 1966 Jan;42(1):51-2. French. PubMed PMID: 5986626. 20: Tanabe S, Sakaguchi T. Studies on the Voges-Proskauer reaction. IX. A new spectrophotometric determination method for moroxydine by Voges-Proskauer reaction. Chem Pharm Bull (Tokyo). 1979 Mar;27(3):813-5. PubMed PMID: 554745.