MedKoo Cat#: 330112 | Name: Morin Hydrate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Morin is a yellow chemical compound that can be isolated from Maclura pomifera (Osage orange), Maclura tinctoria (old fustic) and from leaves of Psidium guajava (common guava). In a preclinical in vitro study, morin was found to be a weak inhibitor of fatty acid synthase with an IC50 of 2.33 μM. Morin was also found to inhibit amyloid formation by islet amyloid polypeptide (or amylin) and disaggregate amyloid fibers. Morin can be used to test for the presence of aluminium or tin in a solution, since it forms characteristically fluorescent coordination complexes with them.

Chemical Structure

Morin Hydrate
Morin Hydrate
CAS#654055-01-3 (hydrate)

Theoretical Analysis

MedKoo Cat#: 330112

Name: Morin Hydrate

CAS#: 654055-01-3 (hydrate)

Chemical Formula: C15H12O8

Exact Mass: 0.0000

Molecular Weight: 320.25

Elemental Analysis: C, 56.26; H, 3.78; O, 39.97

Price and Availability

Size Price Availability Quantity
250mg USD 285.00 2 weeks
1g USD 550.00 2 weeks
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Synonym
Morin Hydrate; NSC 19801; AI3-38057; Al-Morin; C.I. Natural Yellow 11; C.I. Natural Yellow 11 (VAN); C.I. Natural Yellow 8; Osage Orange; Osage Orange Crystals.
IUPAC/Chemical Name
2',3,4',5,7-Pentahydroxyflavone Hydrate
InChi Key
MYUBTSPIIFYCIU-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H10O7.H2O/c16-6-1-2-8(9(18)3-6)15-14(21)13(20)12-10(19)4-7(17)5-11(12)22-15;/h1-5,16-19,21H;1H2
SMILES Code
O=C1C(O)=C(C2=CC=C(O)C=C2O)OC3=C1C(O)=CC(O)=C3.[H]O[H]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
Morin is a yellow chemical compound that can be isolated from Maclura pomifera (Osage orange), Maclura tinctoria (old fustic) and from leaves of Psidium guajava (common guava).
In vitro activity:
This study tested the potency of morin to inhibit CSCs. Morin has significantly reduced colon cancer cell proliferation, colony formation, migration, and colonospheroid formation in a dose-dependent manner. This study found that morin has a good binding affinity with PUM1 protein with one hydrophobic and two hydrogen bond interactions. Further, the immunofluorescence results have also shown a reduction in PUM1 expression in colon cancer cell lines after morin treatment. Reference: Med Oncol. 2022 Oct 12;39(12):251. https://pubmed.ncbi.nlm.nih.gov/36224472/
In vivo activity:
Rats were subjected to oral treatment of morin (50 and 100 mg/kg body weight) for 10 days. MTX (methotrexate) treatment resulted in apoptosis in the liver tissue via increasing mRNA transcript levels of Bax, caspase-3, Apaf-1 and downregulation of Bcl-2. Conversely, treatment with morin at different doses (50 and 100 mg/kg) considerably mitigated MTX-induced oxidative stress and apoptosis in the liver tissue. Morin also mitigated MTX-induced increases of ALT, ALP and AST levels, downregulated mRNA expressions of matrix metalloproteinases (MMP-2 and MMP-9), MAPK14 and MAPK15, JNK, Akt2 and FOXO1 genes. Reference: Mol Biol Rep. 2023 Feb 13. https://pubmed.ncbi.nlm.nih.gov/36781607/

Preparing Stock Solutions

The following data is based on the product molecular weight 320.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Gor R, Saha L, Agarwal S, Karri U, Sohani A, Madhavan T, Pachaiappan R, Ramalingam S. Morin inhibits colon cancer stem cells by inhibiting PUM1 expression in vitro. Med Oncol. 2022 Oct 12;39(12):251. doi: 10.1007/s12032-022-01851-4. PMID: 36224472. 2. Miao Y, Wu X, Xue X, Ma X, Yang L, Zeng X, Hu Y, Dai Y, Wei Z. Morin, the PPARγ agonist, inhibits Th17 differentiation by limiting fatty acid synthesis in collagen-induced arthritis. Cell Biol Toxicol. 2022 Sep 19. doi: 10.1007/s10565-022-09769-3. Epub ahead of print. PMID: 36121554. 3. Kızıl HE, Caglayan C, Darendelioğlu E, Ayna A, Gür C, Kandemir FM, Küçükler S. Morin ameliorates methotrexate-induced hepatotoxicity via targeting Nrf2/HO-1 and Bax/Bcl2/Caspase-3 signaling pathways. Mol Biol Rep. 2023 Feb 13. doi: 10.1007/s11033-023-08286-8. Epub ahead of print. PMID: 36781607. 4. Mohamed OE, Abdallah DM, Fayez AM, Mohamed RA, El-Abhar HS. Morin post-treatment surpassed calpeptin in ameliorating 3-NP-induced cortical neurotoxicity via modulation of glutamate/calpain axis, Kidins220, and BDNF/TrkB/AKT/CREB trajectory. Int Immunopharmacol. 2023 Mar;116:109771. doi: 10.1016/j.intimp.2023.109771. Epub 2023 Feb 1. PMID: 36736222.
In vitro protocol:
1. Gor R, Saha L, Agarwal S, Karri U, Sohani A, Madhavan T, Pachaiappan R, Ramalingam S. Morin inhibits colon cancer stem cells by inhibiting PUM1 expression in vitro. Med Oncol. 2022 Oct 12;39(12):251. doi: 10.1007/s12032-022-01851-4. PMID: 36224472. 2. Miao Y, Wu X, Xue X, Ma X, Yang L, Zeng X, Hu Y, Dai Y, Wei Z. Morin, the PPARγ agonist, inhibits Th17 differentiation by limiting fatty acid synthesis in collagen-induced arthritis. Cell Biol Toxicol. 2022 Sep 19. doi: 10.1007/s10565-022-09769-3. Epub ahead of print. PMID: 36121554.
In vivo protocol:
1. Kızıl HE, Caglayan C, Darendelioğlu E, Ayna A, Gür C, Kandemir FM, Küçükler S. Morin ameliorates methotrexate-induced hepatotoxicity via targeting Nrf2/HO-1 and Bax/Bcl2/Caspase-3 signaling pathways. Mol Biol Rep. 2023 Feb 13. doi: 10.1007/s11033-023-08286-8. Epub ahead of print. PMID: 36781607. 2. Mohamed OE, Abdallah DM, Fayez AM, Mohamed RA, El-Abhar HS. Morin post-treatment surpassed calpeptin in ameliorating 3-NP-induced cortical neurotoxicity via modulation of glutamate/calpain axis, Kidins220, and BDNF/TrkB/AKT/CREB trajectory. Int Immunopharmacol. 2023 Mar;116:109771. doi: 10.1016/j.intimp.2023.109771. Epub 2023 Feb 1. PMID: 36736222.
1: Hu J, Guo X, Yang L. Morin inhibits proliferation and self-renewal of CD133(+) melanoma cells by upregulating miR-216a. J Pharmacol Sci. 2018 Feb 16. pii: S1347-8613(18)30023-9. doi: 10.1016/j.jphs.2018.02.003. [Epub ahead of print] PubMed PMID: 29496393. 2: Memon AF, Solangi AR, Memon SQ, Mallah A, Memon N. Quantitative separation of hesperidin, chrysin, epicatechin, epigallocatechin gallate, and morin using ionic liquid as a buffer additive in capillary electrophoresis. Electrophoresis. 2018 Feb 27. doi: 10.1002/elps.201700421. [Epub ahead of print] PubMed PMID: 29484675. 3: Sharma SH, Kumar JS, Chellappan DR, Nagarajan S. Molecular chemoprevention by morin - A plant flavonoid that targets nuclear factor kappa B in experimental colon cancer. Biomed Pharmacother. 2018 Apr;100:367-373. doi: 10.1016/j.biopha.2018.02.035. Epub 2018 Feb 16. PubMed PMID: 29453046. 4: Singh M, Thakur V, Deshmukh R, Sharma A, Rathore MS, Kumar A, Mishra N. Development and characterization of morin hydrate-loaded micellar nanocarriers for the effective management of Alzheimer's disease. J Microencapsul. 2018 Mar 1:1-12. doi: 10.1080/02652048.2018.1441916. [Epub ahead of print] PubMed PMID: 29448848. 5: Singh MP, Chauhan AK, Kang SC. Morin hydrate ameliorates cisplatin-induced ER stress, inflammation and autophagy in HEK-293 cells and mice kidney via PARP-1 regulation. Int Immunopharmacol. 2018 Mar;56:156-167. doi: 10.1016/j.intimp.2018.01.031. Epub 2018 Feb 3. PubMed PMID: 29414646. 6: Thangarajan S, Vedagiri A, Somasundaram S, Sakthimanogaran R, Murugesan M. Neuroprotective effect of morin on lead acetate- induced apoptosis by preventing cytochrome c translocation via regulation of Bax/Bcl-2 ratio. Neurotoxicol Teratol. 2018 Jan 17;66:35-45. doi: 10.1016/j.ntt.2018.01.006. [Epub ahead of print] PubMed PMID: 29353014. 7: Yuan W, Ahmad S, Najar A. Morin, a plant derived flavonoid, modulates the expression of peroxisome proliferator-activated receptor-γ coactivator-1α mediated by AMPK pathway in hepatic stellate cells. Am J Transl Res. 2017 Dec 15;9(12):5662-5670. eCollection 2017. PubMed PMID: 29312518; PubMed Central PMCID: PMC5752916. 8: Sang L, Wang XM, Xu DY, Sang LX, Han Y, Jiang LY. Morin enhances hepatic Nrf2 expression in a liver fibrosis rat model. World J Gastroenterol. 2017 Dec 21;23(47):8334-8344. doi: 10.3748/wjg.v23.i47.8334. PubMed PMID: 29307993; PubMed Central PMCID: PMC5743504. 9: Wang N, Zhang J, Qin M, Yi W, Yu S, Chen Y, Guan J, Zhang R. Amelioration of streptozotocin induced pancreatic β cell damage by morin: Involvement of the AMPK FOXO3 catalase signaling pathway. Int J Mol Med. 2018 Mar;41(3):1409-1418. doi: 10.3892/ijmm.2017.3357. Epub 2017 Dec 29. PubMed PMID: 29286118; PubMed Central PMCID: PMC5819920. 10: Olonode ET, Aderibigbe AO, Adeoluwa OA, Eduviere AT, Ben-Azu B. Morin hydrate mitigates rapid eye movement sleep deprivation-induced neurobehavioural impairments and loss of viable neurons in the hippocampus of mice. Behav Brain Res. 2017 Dec 25. pii: S0166-4328(17)31713-8. doi: 10.1016/j.bbr.2017.12.024. [Epub ahead of print] PubMed PMID: 29284109. 11: Patel P, Parmar K, Das M. Inhibition of insulin amyloid fibrillation by Morin hydrate. Int J Biol Macromol. 2018 Mar;108:225-239. doi: 10.1016/j.ijbiomac.2017.11.168. Epub 2017 Dec 2. PubMed PMID: 29197568. 12: Bachewal P, Gundu C, Yerra VG, Kalvala AK, Areti A, Kumar A. Morin exerts neuroprotection via attenuation of ROS induced oxidative damage and neuroinflammation in experimental diabetic neuropathy. Biofactors. 2017 Nov 28. doi: 10.1002/biof.1397. [Epub ahead of print] PubMed PMID: 29193444. 13: Setuain I, Lecumberri P, Izquierdo M. Response to the letter to the editor by Morin JB et al. regarding "Sprint mechanics return to competition follow-up after 2 hamstring injury on a professional soccer player: A case study with an inertial sensor 3 unit based methodological approach" (Setuain et al. 2017). J Biomech. 2018 Jan 3;66:200-201. doi: 10.1016/j.jbiomech.2017.11.005. Epub 2017 Nov 9. PubMed PMID: 29154087. 14: Yao D, Cui H, Zhou S, Guo L. Morin inhibited lung cancer cells viability, growth, and migration by suppressing miR-135b and inducing its target CCNG2. Tumour Biol. 2017 Oct;39(10):1010428317712443. doi: 10.1177/1010428317712443. PubMed PMID: 28975847. 15: Ben-Azu B, Aderibigbe AO, Omogbiya IA, Ajayi AM, Iwalewa EO. Morin Pretreatment Attenuates Schizophrenia-Like Behaviors in Experimental Animal Models. Drug Res (Stuttg). 2018 Mar;68(3):159-167. doi: 10.1055/s-0043-119127. Epub 2017 Sep 29. PubMed PMID: 28962045. 16: Sithara T, Arun KB, Syama HP, Reshmitha TR, Nisha P. Morin Inhibits Proliferation of SW480 Colorectal Cancer Cells by Inducing Apoptosis Mediated by Reactive Oxygen Species Formation and Uncoupling of Warburg Effect. Front Pharmacol. 2017 Sep 12;8:640. doi: 10.3389/fphar.2017.00640. eCollection 2017. PubMed PMID: 28955240; PubMed Central PMCID: PMC5601037. 17: Shahin NN, Mohamed MM. Nano-sized titanium dioxide toxicity in rat prostate and testis: Possible ameliorative effect of morin. Toxicol Appl Pharmacol. 2017 Nov 1;334:129-141. doi: 10.1016/j.taap.2017.08.014. Epub 2017 Aug 26. PubMed PMID: 28844848. 18: Yu J, Wan K, Sun X. Improved transdermal delivery of morin efficiently inhibits allergic contact dermatitis. Int J Pharm. 2017 Sep 15;530(1-2):145-154. doi: 10.1016/j.ijpharm.2017.07.062. Epub 2017 Jul 21. PubMed PMID: 28739503. 19: Lin MH, Hsu CC, Lin J, Cheng JT, Wu MC. Investigation of morin-induced insulin secretion in cultured pancreatic cells. Clin Exp Pharmacol Physiol. 2017 Dec;44(12):1254-1262. doi: 10.1111/1440-1681.12815. Epub 2017 Sep 18. PubMed PMID: 28699234. 20: Zhang Q, Zhang F, Thakur K, Wang J, Wang H, Hu F, Zhang JG, Wei ZJ. Molecular mechanism of anti-cancerous potential of Morin extracted from mulberry in Hela cells. Food Chem Toxicol. 2018 Feb;112:466-475. doi: 10.1016/j.fct.2017.07.002. Epub 2017 Jul 6. PubMed PMID: 28689916.