Morin | CAS#480-16-0 | Preservative

MedKoo Cat#: 592414 | Name: Morin

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Morin is used as a Preservative for Delaying Senescence of Banana.

Chemical Structure

Morin

CAS#480-16-0

Theoretical Analysis

MedKoo Cat#: 592414

Name: Morin

CAS#: 480-16-0

Chemical Formula: C15H10O7

Exact Mass: 302.0427

Molecular Weight: 302.24

Elemental Analysis: C, 59.61; H, 3.34; O, 37.05

Price and Availability

Size	Price	Availability	Quantity
5g	USD 350.00	2 weeks
25g	USD 750.00	2 weeks

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Related CAS #

654055-01-3 (hydrate) 480-16-0

Synonym

Morin; NSC 19801; NSC-19801; NSC19801

IUPAC/Chemical Name

2',3,4',5,7-Pentahydroxyflavone

InChi Key

YXOLAZRVSSWPPT-UHFFFAOYSA-N

InChi Code

InChI=1S/C15H10O7/c16-6-1-2-8(9(18)3-6)15-14(21)13(20)12-10(19)4-7(17)5-11(12)22-15/h1-5,16-19,21H

SMILES Code

InChI=1S/C15H10O7/c16-6-1-2-8(9(18)3-6)15-14(21)13(20)12-10(19)4-7(17)5-11(12)22-15/h1-5,16-19,21H

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 302.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Alberdi E, Sánchez-Gómez MV, Ruiz A, Cavaliere F, Ortiz-Sanz C, Quintela-López T, Capetillo-Zarate E, Solé-Domènech S, Matute C. Mangiferin and Morin Attenuate Oxidative Stress, Mitochondrial Dysfunction, and Neurocytotoxicity, Induced by Amyloid Beta Oligomers. Oxid Med Cell Longev. 2018 Jun 14;2018:2856063. doi: 10.1155/2018/2856063. eCollection 2018. PubMed PMID: 30013719; PubMed Central PMCID: PMC6022276. 2: Zhu H, Yang J, Jiang Y, Zeng J, Zhou X, Hua Y, Yang B. Morin as a Preservative for Delaying Senescence of Banana. Biomolecules. 2018 Jul 12;8(3). pii: E52. doi: 10.3390/biom8030052. PubMed PMID: 30002341. 3: Kataria R, Sobarzo-Sanchez E, Khatkar A. Role of Morin in Neurodegenerative Diseases: A review. Curr Top Med Chem. 2018 Jul 11. doi: 10.2174/1568026618666180711153416. [Epub ahead of print] PubMed PMID: 29992884. 4: Kuzu M, Kandemir FM, Yildirim S, Kucukler S, Caglayan C, Turk E. Morin attenuates doxorubicin-induced heart and brain damage by reducing oxidative stress, inflammation and apoptosis. Biomed Pharmacother. 2018 Jul 2;106:443-453. doi: 10.1016/j.biopha.2018.06.161. [Epub ahead of print] PubMed PMID: 29990832. 5: Broeckx BJG, Vezzoni A, Bogaerts E, Bertal M, Bosmans T, Stock E, Deforce D, Peelman L, Saunders JH. Reply to the Letter: 'Le Scientisme, c'est la Prétention indue au Monopole de vérité, alors que le Propre de la Science c'est de dire: il n'y a pas de Monopole' (Edgar Morin). Vet Comp Orthop Traumatol. 2018 Jul 4. doi: 10.1055/s-0038-1653959. [Epub ahead of print] PubMed PMID: 29972848. 6: Liu S, Wu N, Miao J, Huang Z, Li X, Jia P, Guo Y, Jia D. Protective effect of morin on myocardial ischemia reperfusion injury in rats. Int J Mol Med. 2018 Jun 26. doi: 10.3892/ijmm.2018.3743. [Epub ahead of print] PubMed PMID: 29956744. 7: Ben-Azu B, Aderibigbe AO, Eneni AO, Ajayi AM, Umukoro S, Iwalewa EO. Morin Attenuates Neurochemical Changes and Increased Oxidative/Nitrergic Stress in Brains of Mice Exposed to Ketamine: Prevention and Reversal of Schizophrenia-Like Symptoms. Neurochem Res. 2018 Jun 28. doi: 10.1007/s11064-018-2590-z. [Epub ahead of print] PubMed PMID: 29956036. 8: El-Haddad AE, Sheta NM, Boshra SA. Isolation, Formulation, and Efficacy Enhancement of Morin Emulsified Carriers Against Lung Toxicity in Rats. AAPS PharmSciTech. 2018 Jul;19(5):2346-2357. doi: 10.1208/s12249-018-1072-6. Epub 2018 Jun 4. PubMed PMID: 29869310. 9: Arun KG, Sharanya CS, Sadasivan C. Computational and experimental validation of morin as adenosine deaminase inhibitor. J Recept Signal Transduct Res. 2018 Jun;38(3):240-245. doi: 10.1080/10799893.2018.1476543. Epub 2018 May 29. PubMed PMID: 29843562. 10: Sapmaz C, Firat T, Kukner A, Bozcaarmutlu A. Modulation of xenobiotic metabolizing enzyme activities in rat liver by co-administration of morin, endosulfan, and 7,12-dimethylbenz[a]anthracene. Drug Chem Toxicol. 2018 May 18:1-9. doi: 10.1080/01480545.2018.1471089. [Epub ahead of print] PubMed PMID: 29772942. 11: Ikeuchi-Takahashi Y, Kobayashi A, Ishihara C, Matsubara T, Matsubara H, Onishi H. Influence of Polysorbate 60 on Formulation Properties and Bioavailability of Morin-Loaded Nanoemulsions with and without Low-Saponification-Degree Polyvinyl Alcohol. Biol Pharm Bull. 2018;41(5):754-760. doi: 10.1248/bpb.b17-00964. PubMed PMID: 29709912. 12: Li J, Yang Y, Lu L, Ma Q, Zhang J. Preparation, characterization and systemic application of self-assembled hydroxyethyl starch nanoparticles-loaded flavonoid Morin for hyperuricemia therapy. Int J Nanomedicine. 2018 Apr 10;13:2129-2141. doi: 10.2147/IJN.S158585. eCollection 2018. PubMed PMID: 29692610; PubMed Central PMCID: PMC5901201. 13: Ben-Azu B, Aderibigbe AO, Ajayi AM, Eneni AO, Umukoro S, Iwalewa EO. Involvement of GABAergic, BDNF and Nox-2 mechanisms in the prevention and reversal of ketamine-induced schizophrenia-like behavior by morin in mice. Brain Res Bull. 2018 May;139:292-306. doi: 10.1016/j.brainresbull.2018.03.006. Epub 2018 Mar 13. PubMed PMID: 29548911. 14: Hu J, Guo X, Yang L. Morin inhibits proliferation and self-renewal of CD133(+) melanoma cells by upregulating miR-216a. J Pharmacol Sci. 2018 Mar;136(3):114-120. doi: 10.1016/j.jphs.2018.02.003. Epub 2018 Feb 16. PubMed PMID: 29496393. 15: Memon AF, Solangi AR, Memon SQ, Mallah A, Memon N. Quantitative separation of hesperidin, chrysin, epicatechin, epigallocatechin gallate, and morin using ionic liquid as a buffer additive in capillary electrophoresis. Electrophoresis. 2018 Jul;39(13):1606-1612. doi: 10.1002/elps.201700421. Epub 2018 Mar 30. PubMed PMID: 29484675. 16: Sharma SH, Kumar JS, Chellappan DR, Nagarajan S. Molecular chemoprevention by morin - A plant flavonoid that targets nuclear factor kappa B in experimental colon cancer. Biomed Pharmacother. 2018 Apr;100:367-373. doi: 10.1016/j.biopha.2018.02.035. Epub 2018 Feb 16. PubMed PMID: 29453046. 17: Singh M, Thakur V, Deshmukh R, Sharma A, Rathore MS, Kumar A, Mishra N. Development and characterization of morin hydrate-loaded micellar nanocarriers for the effective management of Alzheimer's disease. J Microencapsul. 2018 Mar;35(2):137-148. doi: 10.1080/02652048.2018.1441916. Epub 2018 Mar 1. PubMed PMID: 29448848. 18: Singh MP, Chauhan AK, Kang SC. Morin hydrate ameliorates cisplatin-induced ER stress, inflammation and autophagy in HEK-293 cells and mice kidney via PARP-1 regulation. Int Immunopharmacol. 2018 Mar;56:156-167. doi: 10.1016/j.intimp.2018.01.031. Epub 2018 Feb 3. PubMed PMID: 29414646. 19: Thangarajan S, Vedagiri A, Somasundaram S, Sakthimanogaran R, Murugesan M. Neuroprotective effect of morin on lead acetate- induced apoptosis by preventing cytochrome c translocation via regulation of Bax/Bcl-2 ratio. Neurotoxicol Teratol. 2018 Mar - Apr;66:35-45. doi: 10.1016/j.ntt.2018.01.006. Epub 2018 Jan 17. PubMed PMID: 29353014. 20: Yuan W, Ahmad S, Najar A. Morin, a plant derived flavonoid, modulates the expression of peroxisome proliferator-activated receptor-γ coactivator-1α mediated by AMPK pathway in hepatic stellate cells. Am J Transl Res. 2017 Dec 15;9(12):5662-5670. eCollection 2017. PubMed PMID: 29312518; PubMed Central PMCID: PMC5752916.