Iberdomide, also known as CC-220, is potentially for the treatment of systemic lupus erythematosus. Iberdomide significantly reduced Ikaros and Aiolos protein levels in B cells, T cells and monocytes. In SLE PBMC cultures, iberdomide inhibited anti-dsDNA and anti-phospholipid autoantibody production (IC50 ≈10 nM).
MedKoo Cat#: 528831
Name: Iberdomide
CAS#: 1323403-33-3 (free base)
Chemical Formula: C25H27N3O5
Exact Mass: 449.1951
Molecular Weight: 449.50
Elemental Analysis: C, 66.80; H, 6.05; N, 9.35; O, 17.80
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 125.0 | 278.09 |
The following data is based on the product molecular weight 449.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
