PYX 2 | CAS#146999-93-1 | neuropeptide antagonist

MedKoo Cat#: 598057 | Name: PYX 2

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PYX 2 is a neuropeptide Y receptor antagonist.

Chemical Structure

PYX 2

CAS#146999-93-1

Theoretical Analysis

MedKoo Cat#: 598057

Name: PYX 2

CAS#: 146999-93-1

Chemical Formula: C77H108Cl4N18O17

Exact Mass: 1696.6894

Molecular Weight: 1699.62

Elemental Analysis: C, 54.41; H, 6.41; Cl, 8.34; N, 14.83; O, 16.00

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

PYX 2; PYX-2; PYX2;

IUPAC/Chemical Name

(2S,5S,8S,11S,14R,17S,20S,23S,26S,29S)-23-(2-amino-2-oxoethyl)-8-(3-amino-3-oxopropyl)-17,26-di((S)-sec-butyl)-2,29-bis(3-(2,6-dichlorobenzyl)-4-hydroxybenzyl)-5,11-bis(3-guanidinopropyl)-14-((S)-1-hydroxyethyl)-20-isobutyl-4,7,10,13,16,19,22,25,28,31-decaoxo-3,6,9,12,15,18,21,24,27,30-decaazadotriacontanoic acid

InChi Key

ZAQGGXGNZHMCAL-JPXADNNBSA-N

InChi Code

InChI=1S/C77H108Cl4N18O17/c1-9-38(5)63(97-71(111)56(90-41(8)101)32-42-21-24-59(102)44(30-42)34-46-48(78)15-11-16-49(46)79)72(112)95-57(36-62(83)105)69(109)94-55(29-37(3)4)70(110)98-64(39(6)10-2)73(113)99-65(40(7)100)74(114)93-53(20-14-28-89-77(86)87)66(106)92-54(23-26-61(82)104)68(108)91-52(19-13-27-88-76(84)85)67(107)96-58(75(115)116)33-43-22-25-60(103)45(31-43)35-47-50(80)17-12-18-51(47)81/h11-12,15-18,21-22,24-25,30-31,37-40,52-58,63-65,100,102-103H,9-10,13-14,19-20,23,26-29,32-36H2,1-8H3,(H2,82,104)(H2,83,105)(H,90,101)(H,91,108)(H,92,106)(H,93,114)(H,94,109)(H,95,112)(H,96,107)(H,97,111)(H,98,110)(H,99,113)(H,115,116)(H4,84,85,88)(H4,86,87,89)/t38-,39-,40-,52-,53-,54-,55-,56-,57-,58-,63-,64-,65+/m0/s1

SMILES Code

OC1=CC=C(C=C1CC2=C(Cl)C=CC=C2Cl)C[C@@H](C(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@@H]([C@@H](O)C)NC([C@H]([C@@H](C)CC)NC([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CC3=CC=C(O)C(CC4=C(Cl)C=CC=C4Cl)=C3)NC(C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,699.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Palea S, Corsi M, Rimland JM, Trist DG, Ratti E. Failure of the putative neuropeptide Y antagonists, benextramine and PYX-2, to inhibit Y2 receptors in rat isolated prostatic vas deferens. Br J Pharmacol. 1995 Nov;116(5):2401-6. PubMed PMID: 8581275; PubMed Central PMCID: PMC1909051. 2: Leibowitz SF, Xuereb M, Kim T. Blockade of natural and neuropeptide Y-induced carbohydrate feeding by a receptor antagonist PYX-2. Neuroreport. 1992 Nov;3(11):1023-6. PubMed PMID: 1482761. 3: Beck B, Stricker-Krongrad A, Musse N, Nicolas JP, Burlet C. Putative neuropeptide Y antagonist failed to decrease overeating in obese Zucker rats. Neurosci Lett. 1994 Nov 7;181(1-2):126-8. PubMed PMID: 7898751. 4: Lee MC, Lawson DC, Pappas TN. Neuropeptide Y functions as a physiologic regulator of cephalic phase acid secretion. Regul Pept. 1994 Aug 4;52(3):227-34. PubMed PMID: 7800854. 5: Wieland HA, Willim KD, Entzeroth M, Wienen W, Rudolf K, Eberlein W, Engel W, Doods HN. Subtype selectivity and antagonistic profile of the nonpeptide Y1 receptor antagonist BIBP 3226. J Pharmacol Exp Ther. 1995 Oct;275(1):143-9. PubMed PMID: 7562543. 6: Smith-White M, Moriarty MJ, Potter EK. A comparison of actions of neuropeptide Y (NPY) agonists and antagonists at NPY Y1 and Y2 receptors in anaesthetized rats. Neuropeptides. 1998 Apr;32(2):109-18. PubMed PMID: 9639248. 7: Crowley WR, Ramoz G, Hurst B. Evidence for involvement of neuropeptide Y and melanocortin systems in the hyperphagia of lactation in rats. Pharmacol Biochem Behav. 2003 Jan;74(2):417-24. PubMed PMID: 12479963. 8: Oellerich WF, Malik KU. Neuropeptide Y modulates the vascular response to periarterial nerve stimulation primarily by a postjunctional action in the isolated perfused rat kidney. J Pharmacol Exp Ther. 1993 Sep;266(3):1321-9. PubMed PMID: 8371140.