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MedKoo Cat#: 529101 | Name: Blarcamesine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Blarcamesine, also known as AVex-73 and AE-37, is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease. It is an σ receptor ligand.

Chemical Structure

Blarcamesine
Blarcamesine
CAS#195615-83-9 (free base)

Theoretical Analysis

MedKoo Cat#: 529101

Name: Blarcamesine

CAS#: 195615-83-9 (free base)

Chemical Formula: C19H23NO

Exact Mass: 281.1780

Molecular Weight: 281.40

Elemental Analysis: C, 81.10; H, 8.24; N, 4.98; O, 5.69

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
195615-83-9 (free base) 195615-84-0 (HCl)
Synonym
AE-37; AVex-73; Anavex-2-73; Anavex-273; AE37; AVex73; Anavex273; AE 37; AVex 73; Anavex 2 73; Anavex 273; Blarcamesine
IUPAC/Chemical Name
(R)-1-(2,2-diphenyltetrahydrofuran-3-yl)-N,N-dimethylmethanamine
InChi Key
BOTHKNZTGGXFEQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H23NO/c1-20(2)15-18-13-14-21-19(18,16-9-5-3-6-10-16)17-11-7-4-8-12-17/h3-12,18H,13-15H2,1-2H3
SMILES Code
CN(C)CC1C(C2=CC=CC=C2)(C3=CC=CC=C3)OCC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 281.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Matsueda S, Gao H, Efferson CL, Tsuda N, Ishiyama S, Li Y, Ioannides MG, Fisk B, Peoples GE, Ioannides CG. N-terminally LRMK-linked HER-2 peptides, AE-37 [p776(774-788)] and AE-47 [Ava-F7(776-788)], aid differentiation of E75-TCR+CD8+ cells to perforin-positive cells. Anticancer Res. 2009 Jul;29(7):2427-35. PubMed PMID: 19596910. 2: Li Y, Matsueda S, Efferson CL, Tsuda N, Kawano K, Gao H, Peoples GE, Ioannides CG. Distinct patient responses to activation of T-cells by free HER-2, G89 (777-789) and protected LRMK-linked HER-2, {AE-39 [p776 (Ava-774-788)], AE-47 [(Ava-776-788)] and AE-37[p776 (774-788)]} peptides could lead to development of personalized cancer vaccines. Anticancer Res. 2009 Jan;29(1):41-58. PubMed PMID: 19331132. 3: Tomillero A, Moral MA. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2010 Sep;32(7):517-48. doi: 10.1358/mf.2010.32.7.1549223. PubMed PMID: 21069103. 4: Tomillero A, Moral MA. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2010 Jan-Feb;32(1):47-86. PubMed PMID: 20383346. 5: Tomillero A, Moral MA. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2008 Oct;30(8):643-72. PubMed PMID: 19088949. 6: Díaz-Ortega JL, Bennett JV, Castañeda-Desales D, Quintanilla DM, Martínez D, de Castro JF. Booster immune response in children 6-7 years of age, randomly assigned to four groups with two MMR vaccines applied by aerosol or by injection. Vaccine. 2014 Jun 17;32(29):3680-6. doi: 10.1016/j.vaccine.2014.04.031. PubMed PMID: 24837512. 7: Bayes M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2006 Dec;28(10):719-40. PubMed PMID: 17235418. 8: Xu J, You C, Zhang S, Huang S, Cai B, Wu Z, Li H. Angiogenesis and cell proliferation in human craniopharyngioma xenografts in nude mice. J Neurosurg. 2006 Oct;105(4 Suppl):306-10. PubMed PMID: 17328281. 9: Papacchini F, Goracci C, Sadek FT, Monticelli F, Garcia-Godoy F, Ferrari M. Microtensile bond strength to ground enamel by glass-ionomers, resin-modified glass-ionomers, and resin composites used as pit and fissure sealants. J Dent. 2005 Jul;33(6):459-67. PubMed PMID: 15935265. 10: Vamvakidès A. [Anticonvulsant and forced swim anti-immobility effects of tetrahydro-N, N-dimethyl-2,2-diphenyl-3-furanemethanamine (AE37): common action mechanism?]. Ann Pharm Fr. 2002 Mar;60(2):88-92. Review. French. PubMed PMID: 11976553. 11: Gündoğdu C, Arslan R, Arslan MO, Gicik Y. [Evaluation of cystic and alveolar echinococcosis cases in people in Erzurum and surrounding cities.]. Turkiye Parazitol Derg. 2005;29(3):163-6. Turkish. PubMed PMID: 17160814. 12: Shinagawa K, Tachihara R, Matsusaka N, Sugii S. Immunological cross-reactivity of the fragments of staphylococcal enterotoxins A and E generated by digestion of proteolytic enzymes. J Vet Med Sci. 1991 Apr;53(2):223-7. PubMed PMID: 1713793.