BJP-06–005-3 is a potent and covalent Pin1 inhibitor. BJP-06–005-3 potently inhibited Pin1 catalytic activity with an apparent Ki of 48 nM. BJP-06–005-3 showed 100% covalent labeling of Pin1 as indicated by a 702 Da molecular weight increase, corresponding to modification of Pin1 by BJP-06–005-3 upon loss of its chloride. BJP-06–005-3 engages Pin1 for 48 h following a single 5–10 μM treatment across multiple cancer cell types. BJP-06–005-3 has Pin1-dependent cell viability effects.
MedKoo Cat#: 463247
Name: BJP-06-005-3
CAS#: 2400958-08-7
Chemical Formula: C37H48ClN7O7
Exact Mass: 737.3304
Molecular Weight: 738.28
Elemental Analysis: C, 60.19; H, 6.55; Cl, 4.80; N, 13.28; O, 15.17
The following data is based on the product molecular weight 738.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |