MedKoo Cat#: 584224 | Name: BK 218

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BK 218 is a novel cephalosporin with a dual route of administration and spectrum of activity most similar to that of second-generation cephalosporins. BK-218 was active against Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis but strains resistant to penicillins had higher MICs.

Chemical Structure

BK 218
BK 218
CAS#110008-56-5

Theoretical Analysis

MedKoo Cat#: 584224

Name: BK 218

CAS#: 110008-56-5

Chemical Formula: C15H13ClN7NaO5S2

Exact Mass: 493.0006

Molecular Weight: 493.87

Elemental Analysis: C, 36.48; H, 2.65; Cl, 7.18; N, 19.85; Na, 4.65; O, 16.20; S, 12.98

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
BK 218; BK-218; BK218
IUPAC/Chemical Name
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((3-chloro-5-isoxazolyl)acetyl)amino)-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, monosodium salt, (6R-trans)-
InChi Key
XQPMNRFOIDADDS-HTMVYDOJSA-M
InChi Code
InChI=1S/C15H14ClN7O5S2.Na/c1-22-15(18-20-21-22)30-5-6-4-29-13-10(12(25)23(13)11(6)14(26)27)17-9(24)3-7-2-8(16)19-28-7;/h2,10,13H,3-5H2,1H3,(H,17,24)(H,26,27);/q;+1/p-1/t10-,13-;/m1./s1
SMILES Code
O=C(C(N12)=C(CSC3=NN=NN3C)CS[C@]2([H])[C@H](NC(CC4=CC(Cl)=NO4)=O)C1=O)[O-].[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 493.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Szabó I, Barabás J, Tar A, Kiss L, Filep M, Schmidt T, Marossy K, Tóth-Martinez B, Barabás G, Hernádi F. In vitro investigation of BK-218, a new oral and parenteral cephalosporin. Antimicrob Agents Chemother. 1990 Feb;34(2):349-54. PubMed PMID: 2109582; PubMed Central PMCID: PMC171585. 2: Johnson DM, Jones RN. Antibacterial activity of the investigational oral and parenteral cephalosporin BK-218. Eur J Clin Microbiol Infect Dis. 1992 Feb;11(2):181-8. PubMed PMID: 1396735. 3: Jones RN, Erwin ME, Barrett MS. Antimicrobial activity of three investigational oral cephalosporins (BK-218, cefdinir, and RU29246) against Legionella. Diagn Microbiol Infect Dis. 1991 Nov-Dec;14(6):519-21. PubMed PMID: 1802542.