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MedKoo Cat#: 529317 | Name: Prasterone sulfate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Prasterone sulfate is a HSD11B1 expression inhibitor potentially for the treatment of asthma and burns.

Chemical Structure

Prasterone sulfate
Prasterone sulfate
CAS#651-48-9 (free acid)

Theoretical Analysis

MedKoo Cat#: 529317

Name: Prasterone sulfate

CAS#: 651-48-9 (free acid)

Chemical Formula: C19H28O5S

Exact Mass: 368.1657

Molecular Weight: 368.48

Elemental Analysis: Chemical Formula: C19H28O5S Exact Mass: 368.1657 Molecular Weight: 368.4880 Elemental Analysis: C, 61.93; H, 7.66; O, 21.71; S, 8.70

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
78590-17-7 (sodium) 651-48-9 (free acid)
Synonym
PB-005; PB005; PB 005; DHEAS
IUPAC/Chemical Name
(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl hydrogen sulfate
InChi Key
CZWCKYRVOZZJNM-USOAJAOKSA-N
InChi Code
InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/t13-,14-,15-,16-,18-,19-/m0/s1
SMILES Code
C[C@]1([C@](CC2)([H])[C@]3([H])CC=C4C[C@@H](OS(=O)(O)=O)CC[C@]4(C)[C@@]3([H])CC1)C2=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 368.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Effects of acute and chronic administration of neurosteroid dehydroepiandrosterone sulfate on neuronal excitability in mice. Drug Des Devel Ther. 2016 Mar 21;10:1201-15. doi: 10.2147/DDDT.S102102. PubMed PMID: 27051273; PubMed Central PMCID: PMC4807895. 5: Ziegler CG, Langbein H, Krug AW, Ludwig B, Eisenhofer G, Ehrhart-Bornstein M, Bornstein SR. Direct effect of dehydroepiandrosterone sulfate (DHEAS) on PC-12 cell differentiation processes. Mol Cell Endocrinol. 2011 Apr 10;336(1-2):149-55. doi: 10.1016/j.mce.2010.12.031. PubMed PMID: 21195131. 6: Yue J, Wang L, Huang R, Li S, Ma J, Teng X, Liu W. Dehydroepiandrosterone-sulfate (DHEAS) promotes MIN6 cells insulin secretion via inhibition of AMP-activated protein kinase. Biochem Biophys Res Commun. 2013 Nov 1;440(4):756-61. doi: 10.1016/j.bbrc.2013.10.002. PubMed PMID: 24120945. 7: Krzascik P, Zajda ME, Majewska MD. The neurosteroid dehydroepiandrosterone sulfate, but not androsterone, enhances the antidepressant effect of cocaine examined in the forced swim test--Possible role of serotonergic neurotransmission. Horm Behav. 2015 Apr;70:64-72. doi: 10.1016/j.yhbeh.2014.12.012. PubMed PMID: 25747464. 8: Takeshita RS, Huffman MA, Bercovitch FB, Mouri K, Shimizu K. The influence of age and season on fecal dehydroepiandrosterone-sulfate (DHEAS) concentrations in Japanese macaques (Macaca fuscata). Gen Comp Endocrinol. 2013 Sep 15;191:39-43. doi: 10.1016/j.ygcen.2013.05.019. PubMed PMID: 23751811. 9: Dutov AA, Nikitin DA, Luk'ianova YL, Sverkunova AV, Martynova AV, Ermolina AV. [HPLC analysis of dehydroepiandrosterone sulfate in serum with use of solid-phase extraction on hyper cross-linked polystyrene (Purosep-200)]. Biomed Khim. 2014 Nov-Dec;60(6):651-4. Russian. PubMed PMID: 25552504. 10: Chen AH, Li HY, Wu VC, Lin YH, Huang TS; Taiwan Primary Aldosteronism Investigation (TAIPAI) Study Group.. Serum dehydroepiandrosterone sulfate concentration is lower in women with primary aldosteronism. J Renin Angiotensin Aldosterone Syst. 2015 Mar;16(1):137-44. doi: 10.1177/1470320313483843. PubMed PMID: 23571826. 11: Chernykh ER, Leplina OY, Tyrinova TV, Tikhonova MA, Sakhno LV, Ostanin AA. Contribution of dehydroepiandrosterone sulfate and progesterone to in vitro regulation of tolerogenic activity of IFN-α-induced dendritic cells. Bull Exp Biol Med. 2011 Jun;151(2):205-9. PubMed PMID: 22238751. 12: Taylor MK. Dehydroepiandrosterone and dehydroepiandrosterone sulfate: anabolic, neuroprotective, and neuroexcitatory properties in military men. Mil Med. 2013 Jan;178(1):100-6. PubMed PMID: 23356127. 13: Höllig A, Thiel M, Stoffel-Wagner B, Coburn M, Clusmann H. Neuroprotective properties of dehydroepiandrosterone-sulfate and its relationship to interleukin 6 after aneurysmal subarachnoid hemorrhage: a prospective cohort study. Crit Care. 2015 May 21;19:231. doi: 10.1186/s13054-015-0954-1. PubMed PMID: 25993987; PubMed Central PMCID: PMC4462180. 14: Zarit SH, Whetzel CA, Kim K, Femia EE, Almeida DM, Rovine MJ, Klein LC. Daily stressors and adult day service use by family caregivers: effects on depressive symptoms, positive mood, and dehydroepiandrosterone-sulfate. Am J Geriatr Psychiatry. 2014 Dec;22(12):1592-602. doi: 10.1016/j.jagp.2014.01.013. PubMed PMID: 24566240; PubMed Central PMCID: PMC4119567. 15: Van Voorhees EE, Dennis MF, McClernon FJ, Calhoun PS, Buse NA, Beckham JC. The association of dehydroepiandrosterone and dehydroepiandrosterone sulfate with anxiety sensitivity and electronic diary negative affect among smokers with and without posttraumatic stress disorder. J Clin Psychopharmacol. 2013 Aug;33(4):556-60. doi: 10.1097/JCP.0b013e3182968962. PubMed PMID: 23771199; PubMed Central PMCID: PMC3896952. 16: Hu Q, Zhang SY, Liu F, Zhang YL, Zhu DM, Zang YY. Clinical significance of decreased protein expression of dehydroepiandrosterone sulfate in the development of depression: a meta-analysis. J Affect Disord. 2015 Mar 15;174:416-23. doi: 10.1016/j.jad.2014.11.051. Review. PubMed PMID: 25553402. 17: Lowin T, Weidler C, Jenei-Lanzl Z, Capellino S, Baerwald CG, Buttgereit F, Straub RH. Relationship between placenta growth factor 1 and vascularization, dehydroepiandrosterone sulfate to dehydroepiandrosterone conversion, or aromatase expression in patients with rheumatoid arthritis and patients with osteoarthritis. Arthritis Rheum. 2012 Jun;64(6):1799-808. doi: 10.1002/art.34338. PubMed PMID: 22170453. 18: Morita T, Senzaki K, Ishihara R, Umeda K, Iwata N, Nagai T, Hida H, Nabeshima T, Yukawa K, Ozaki N, Noda Y. Plasma dehydroepiandrosterone sulfate levels in patients with major depressive disorder correlate with remission during treatment with antidepressants. Hum Psychopharmacol. 2014 May;29(3):280-6. doi: 10.1002/hup.2400. PubMed PMID: 24911578. 19: Takeuchi K, Goto H, Ito Y, Sato M, Matsumoto S, Senba T, Yamada H, Umehara K. Dehydroepiandrosterone sulfate and cytochrome P450 inducers alleviate fatty liver in male rats fed an orotic acid-supplemented diet. J Toxicol Sci. 2015 Apr;40(2):181-91. doi: 10.2131/jts.40.181. PubMed PMID: 25786523. 20: Krijthe BP, de Jong FH, Hofman A, Franco OH, Witteman JC, Stricker BH, Heeringa J. Dehydroepiandrosterone sulfate levels and risk of atrial fibrillation: the Rotterdam Study. Eur J Prev Cardiol. 2014 Mar;21(3):291-8. doi: 10.1177/2047487312467903. PubMed PMID: 23152363.

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