VU0240382 | CAS#1092550-36-1 | PAM mGlu5

MedKoo Cat#: 532898 | Name: VU0240382

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VU0240382 is an allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5.

Chemical Structure

VU0240382

CAS#1092550-36-1

Theoretical Analysis

MedKoo Cat#: 532898

Name: VU0240382

CAS#: 1092550-36-1

Chemical Formula: C17H13NO

Exact Mass: 247.0997

Molecular Weight: 247.30

Elemental Analysis: C, 82.57; H, 5.30; N, 5.66; O, 6.47

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

VU0240382, VU-0240382, VU 0240382

IUPAC/Chemical Name

6-(2-phenylethynyl)-1,2,3,4-tetrahydroisoquinolin-1-one

InChi Key

BOVJHNHRQNCDEQ-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H13NO/c19-17-16-9-8-14(12-15(16)10-11-18-17)7-6-13-4-2-1-3-5-13/h1-5,8-9,12H,10-11H2,(H,18,19)

SMILES Code

O=C1NCCC2=C1C=CC(C#CC3=CC=CC=C3)=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 247.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Noetzel MJ, Rook JM, Vinson PN, Cho HP, Days E, Zhou Y, Rodriguez AL, Lavreysen H, Stauffer SR, Niswender CM, Xiang Z, Daniels JS, Jones CK, Lindsley CW, Weaver CD, Conn PJ. Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function. Mol Pharmacol. 2012 Feb;81(2):120-33. doi: 10.1124/mol.111.075184. Epub 2011 Oct 21. PubMed PMID: 22021324; PubMed Central PMCID: PMC3263948.