MedKoo Cat#: 462091 | Name: dTAG-7

Description:

WARNING: This product is for research use only, not for human or veterinary use.

dTAG-7 is a first generation degrader for mutant FKBP12F36V fusion proteins. It is a useful alternative to genetic methods for target validation.

Chemical Structure

dTAG-7
dTAG-7
CAS#2064175-32-0

Theoretical Analysis

MedKoo Cat#: 462091

Name: dTAG-7

CAS#: 2064175-32-0

Chemical Formula: C63H79N5O19

Exact Mass: 1209.5369

Molecular Weight: 1210.34

Elemental Analysis: C, 62.52; H, 6.58; N, 5.79; O, 25.12

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
dTAG-7
IUPAC/Chemical Name
(1R)-3-(3,4-Dimethoxyphenyl)-1-(2-((19-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-2,18-dioxo-7,10,13-trioxa-3,17-diazanonadecyl)oxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
InChi Key
IFCAWDLUIZXIPI-FJDAOBEISA-N
InChi Code
InChI=1S/C63H79N5O19/c1-7-42(41-36-52(79-4)58(81-6)53(37-41)80-5)60(73)67-28-11-10-17-46(67)63(76)87-48(23-20-40-21-24-49(77-2)51(35-40)78-3)43-15-8-9-18-47(43)85-38-55(70)64-26-13-29-82-31-33-84-34-32-83-30-14-27-65-56(71)39-86-50-19-12-16-44-57(50)62(75)68(61(44)74)45-22-25-54(69)66-59(45)72/h8-9,12,15-16,18-19,21,24,35-37,42,45-46,48H,7,10-11,13-14,17,20,22-23,25-34,38-39H2,1-6H3,(H,64,70)(H,65,71)(H,66,69,72)/t42-,45?,46-,48+/m0/s1
SMILES Code
O=C([C@H]1N(C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)CCCC1)O[C@@H](C3=CC=CC=C3OCC(NCCCOCCOCCOCCCNC(COC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)=O)=O)CCC7=CC=C(OC)C(OC)=C7
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,210.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Acute Pharmacologic Degradation of a Stable Antigen Enhances Its Direct Presentation on MHC Class I Molecules Sarah C. Moser, Jane S. A. Voerman, Dennis L. Buckley, Georg E. Winter, Christopher Schliehe Front Immunol. 2017; 8: 1920. Published online 2018 Jan 8. doi: 10.3389/fimmu.2017.01920 PMCID: PMC5766668 2: The dTAG system for immediate and target-specific protein degradation Behnam Nabet, Justin M. Roberts, Dennis L. Buckley, Joshiawa Paulk, Shiva Dastjerdi, Annan Yang, Alan L. Leggett, Michael A. Erb, Matthew A. Lawlor, Amanda Souza, Thomas G. Scott, Sarah Vittori, Jennifer A. Perry, Jun Qi, Georg E. Winter, Kwok-Kin Wong, Nathanael S. Gray, James E. Bradner Nat Chem Biol. Author manuscript; available in PMC 2018 Dec 17.Published in final edited form as: Nat Chem Biol. 2018 May; 14(5): 431 441. Published online 2018 Mar 26. doi: 10.1038/s41589-018-0021-8 PMCID: PMC6295913 3: MELK is not necessary for the proliferation of basal-like breast cancer cells Hai-Tsang Huang, Hyuk-Soo Seo, Tinghu Zhang, Yubao Wang, Baishan Jiang, Qing Li, Dennis L Buckley, Behnam Nabet, Justin M Roberts, Joshiawa Paulk, Shiva Dastjerdi, Georg E Winter, Hilary McLauchlan, Jennifer Moran, James E Bradner, Michael J Eck, Sirano Dhe-Paganon, Jean J Zhao, Nathanael S Gray eLife. 2017; 6: e26693. Published online 2017 Sep 19. doi: 10.7554/eLife.26693 PMCID: PMC5605198 4: Transcription control by the ENL YEATS domain in acute leukemia Michael A. Erb, Thomas G. Scott, Bin E. Li, Huafeng Xie, Joshiawa Paulk, Hyuk-Soo Seo, Amanda Souza, Justin M. Roberts, Shiva Dastjerdi, Dennis L. Buckley, Neville E. Sanjana, Ophir Shalem, Behnam Nabet, Rhamy Zeid, Nana K. Offei-Addo, Sirano Dhe-Paganon, Feng Zhang, Stuart H. Orkin, Georg E. Winter, James E. Bradner Nature. Author manuscript; available in PMC 2017 Sep 1.Published in final edited form as: Nature. 2017 Mar 9; 543(7644): 270–274. Published online 2017 Mar 1. doi: 10.1038/nature21688 PMCID: PMC5497220 5: Human cytomegalovirus IE2 drives transcription initiation from a select subset of late infection viral promoters by host RNA polymerase II Ming Li, Christopher B. Ball, Geoffrey Collins, Qiaolin Hu, Donal S. Luse, David H. Price, Jeffery L. Meier PLoS Pathog. 2020 Apr; 16(4): e1008402. Published online 2020 Apr 6. doi: 10.1371/journal.ppat.1008402 PMCID: PMC7162547 6: A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader Hai-Tsang Huang, Dennis Dobrovolsky, Joshiawa Paulk, Guang Yang, Ellen L. Weisberg, Zainab M. Doctor, Dennis L. Buckley, Joong-Heui Cho, Eunhwa Ko, Jaebong Jang, Kun Shi, Hwan Geun Choi, James D. Griffin, Ying Li, Steven P. Treon, Eric S. Fischer, James E. Bradner, Li Tan, Nathanael S. Gray Cell Chem Biol. Author manuscript; available in PMC 2019 Mar 21.Published in final edited form as: Cell Chem Biol. 2018 Jan 18; 25(1): 88–99.e6. Published online 2017 Nov 9. doi: 10.1016/j.chembiol.2017.10.005 PMCID: PMC6427047