Lytixar free base | LTX-109 | CAS#1166254-80-3 | Antimicrobial Peptide

MedKoo Cat#: 407386 | Name: Lytixar free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lytixar, also known as LTX-109, is a Synthetic Antimicrobial Peptide, showing activity against Methicillin-Resistant, Vancomycin-Intermediate, Vancomycin-Resistant, Daptomycin-Nonsusceptible, and Linezolid-Nonsusceptible Staphylococcus aureus. LTX-109 demonstrated a MIC range of 2 to 4 μg/ml and dose-dependent rapid bactericidal activity against S. aureus. This activity was not influenced by resistance to other antistaphylococcal agents.

Chemical Structure

Lytixar free base

CAS#1166254-80-3 (free base)

Theoretical Analysis

MedKoo Cat#: 407386

Name: Lytixar free base

CAS#: 1166254-80-3 (free base)

Chemical Formula: C43H73Cl4N11O3

Exact Mass: 787.5585

Molecular Weight: 933.93

Elemental Analysis: C, 55.30; H, 7.88; Cl, 15.18; N, 16.50; O, 5.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

1166254-80-3 (free base) Lytixar HCl

Synonym

Lytixar; LTX-109; LTX 109; LTX109; Lytixar free base; Voxvoganan;

IUPAC/Chemical Name

(S)-2-amino-5-guanidino-N-((S)-1-(((S)-5-guanidino-1-oxo-1-(phenethylamino)pentan-2-yl)amino)-1-oxo-3-(2,5,7-tri-tert-butyl-1H-indol-3-yl)propan-2-yl)pentanamide

InChi Key

ZVOYWSKEBVVLGW-ZDCRTTOTSA-N

InChi Code

InChI=1S/C43H69N11O3/c1-41(2,3)27-23-28-29(35(43(7,8)9)54-34(28)30(24-27)42(4,5)6)25-33(53-36(55)31(44)17-13-20-50-39(45)46)38(57)52-32(18-14-21-51-40(47)48)37(56)49-22-19-26-15-11-10-12-16-26/h10-12,15-16,23-24,31-33,54H,13-14,17-22,25,44H2,1-9H3,(H,49,56)(H,52,57)(H,53,55)(H4,45,46,50)(H4,47,48,51)/t31-,32-,33-/m0/s1

SMILES Code

O=C(N[C@@H](CC1=C(C(C)(C)C)NC2=C1C=C(C(C)(C)C)C=C2C(C)(C)C)C(N[C@@H](CCCNC(N)=N)C(NCCC3=CC=CC=C3)=O)=O)[C@@H](N)CCCNC(N)=N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 933.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Nilsson AC, Janson H, Wold H, Fugelli A, Andersson K, Håkangård C, Olsson P, Olsen WM. LTX-109 is a novel agent for nasal decolonization of methicillin-resistant and -sensitive Staphylococcus aureus. Antimicrob Agents Chemother. 2015 Jan;59(1):145-51. doi: 10.1128/AAC.03513-14. PubMed PMID: 25331699; PubMed Central PMCID: PMC4291342. 2: Saravolatz LD, Pawlak J, Johnson L, Bonilla H, Saravolatz LD 2nd, Fakih MG, Fugelli A, Olsen WM. In vitro activities of LTX-109, a synthetic antimicrobial peptide, against methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, daptomycin-nonsusceptible, and linezolid-nonsusceptible Staphylococcus aureus. Antimicrob Agents Chemother. 2012 Aug;56(8):4478-82. doi: 10.1128/AAC.00194-12. PubMed PMID: 22585222; PubMed Central PMCID: PMC3421571. 3: Isaksson J, Brandsdal BO, Engqvist M, Flaten GE, Svendsen JS, Stensen W. A synthetic antimicrobial peptidomimetic (LTX 109): stereochemical impact on membrane disruption. J Med Chem. 2011 Aug 25;54(16):5786-95. doi: 10.1021/jm200450h. PubMed PMID: 21732630. 4: Scott RW, Tew GN. Mimics of Host Defense Proteins; Strategies for Translation to Therapeutic Applications. Curr Top Med Chem. 2017;17(5):576-589. Review. PubMed PMID: 27411325. 5: Bojsen R, Torbensen R, Larsen CE, Folkesson A, Regenberg B. The synthetic amphipathic peptidomimetic LTX109 is a potent fungicide that disturbs plasma membrane integrity in a sphingolipid dependent manner. PLoS One. 2013 Jul 12;8(7):e69483. doi: 10.1371/journal.pone.0069483. PubMed PMID: 23874964; PubMed Central PMCID: PMC3709891.