Synonym
Lytixar; LTX-109; LTX 109; LTX109; LTX-109 HCl; Lytixar HCl; Lytixar hydrochloride; Lytixar; Voxvoganan;
IUPAC/Chemical Name
L-Argininamide, L-arginyl-2,5,7-tris(1,1-dimethylethyl)-L-tryptophyl-N-(2-phenylethyl)- tetrahydrochloride
InChi Key
LLPGVFVCDNUOCS-VXEPYQPUSA-N
InChi Code
InChI=1S/C43H69N11O3.4ClH/c1-41(2,3)27-23-28-29(35(43(7,8)9)53-34(28)30(24-27)42(4,5)6)25-32(52-37(56)31(44)17-13-20-50-39(46)47)38(57)54(22-19-26-15-11-10-12-16-26)33(36(45)55)18-14-21-51-40(48)49;;;;/h10-12,15-16,23-24,31-33,53H,13-14,17-22,25,44H2,1-9H3,(H2,45,55)(H,52,56)(H4,46,47,50)(H4,48,49,51);4*1H/t31-,32-,33-;;;;/m0..../s1
SMILES Code
[H]Cl.[H]Cl.[H]Cl.[H]Cl.N=C(N)NCCC[C@@H](C(N)=O)N(C([C@H](CC1=C(C(C)(C)C)NC2=C1C=C(C(C)(C)C)C=C2C(C)(C)C)NC([C@@H](N)CCCNC(N)=N)=O)=O)CCC3=CC=CC=C3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
788.10
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Saravolatz LD, Pawlak J, Martin H, Saravolatz S, Johnson L, Wold H, Husbyn M, Olsen WM. Postantibiotic effect and postantibiotic sub-MIC effect of LTX-109 and mupirocin on Staphylococcus aureus blood isolates. Lett Appl Microbiol. 2017 Nov;65(5):410-413. doi: 10.1111/lam.12792. Epub 2017 Sep 19. PubMed PMID: 28802058.
2: Scott RW, Tew GN. Mimics of Host Defense Proteins; Strategies for Translation to Therapeutic Applications. Curr Top Med Chem. 2017;17(5):576-589. Review. PubMed PMID: 27411325.
3: Nilsson AC, Janson H, Wold H, Fugelli A, Andersson K, Håkangård C, Olsson P, Olsen WM. LTX-109 is a novel agent for nasal decolonization of methicillin-resistant and -sensitive Staphylococcus aureus. Antimicrob Agents Chemother. 2015 Jan;59(1):145-51. doi: 10.1128/AAC.03513-14. Epub 2014 Oct 20. PubMed PMID: 25331699; PubMed Central PMCID: PMC4291342.
4: Bojsen R, Torbensen R, Larsen CE, Folkesson A, Regenberg B. The synthetic amphipathic peptidomimetic LTX109 is a potent fungicide that disturbs plasma membrane integrity in a sphingolipid dependent manner. PLoS One. 2013 Jul 12;8(7):e69483. doi: 10.1371/journal.pone.0069483. Print 2013. PubMed PMID: 23874964; PubMed Central PMCID: PMC3709891.
5: Saravolatz LD, Pawlak J, Johnson L, Bonilla H, Saravolatz LD 2nd, Fakih MG, Fugelli A, Olsen WM. In vitro activities of LTX-109, a synthetic antimicrobial peptide, against methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, daptomycin-nonsusceptible, and linezolid-nonsusceptible Staphylococcus aureus. Antimicrob Agents Chemother. 2012 Aug;56(8):4478-82. doi: 10.1128/AAC.00194-12. Epub 2012 May 14. PubMed PMID: 22585222; PubMed Central PMCID: PMC3421571.
6: Isaksson J, Brandsdal BO, Engqvist M, Flaten GE, Svendsen JS, Stensen W. A synthetic antimicrobial peptidomimetic (LTX 109): stereochemical impact on membrane disruption. J Med Chem. 2011 Aug 25;54(16):5786-95. doi: 10.1021/jm200450h. Epub 2011 Jul 26. PubMed PMID: 21732630.
