JCP276 | CAS# | inhibitor

MedKoo Cat#: 208134 | Name: JCP276

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JCP276 is a narrow-spectrum inhibitor of Mycobacterium tuberculosis growth. Phthiocerol dimycocerate confers resistance to JCP276. JCP276 inhibits multiple nonessential serine hydrolases.

Chemical Structure

JCP276

CAS#Unknown

Theoretical Analysis

MedKoo Cat#: 208134

Name: JCP276

CAS#: Unknown

Chemical Formula: C19H16BrClN2O4

Exact Mass: 449.9982

Molecular Weight: 451.70

Elemental Analysis: C, 50.52; H, 3.57; Br, 17.69; Cl, 7.85; N, 6.20; O, 14.17

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

JCP276; JCP-276; JCP 276;

IUPAC/Chemical Name

1-(3-(3-Bromopropoxy)-4-chloro-1-oxo-1H-isochromen-7-yl)-3-phenylurea

InChi Key

NOUCBQBZTFYQQV-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H16BrClN2O4/c20-9-4-10-26-18-16(21)14-8-7-13(11-15(14)17(24)27-18)23-19(25)22-12-5-2-1-3-6-12/h1-3,5-8,11H,4,9-10H2,(H2,22,23,25)

SMILES Code

O=C(NC1=CC=CC=C1)NC2=CC3=C(C=C2)C(Cl)=C(OCCCBr)OC3=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 451.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Babin BM, Keller LJ, Pinto Y, Li VL, Eneim AS, Vance SE, Terrell SM, Bhatt AS, Long JZ, Bogyo M. Identification of covalent inhibitors that disrupt M. tuberculosis growth by targeting multiple serine hydrolases involved in lipid metabolism. Cell Chem Biol. 2022 May 19;29(5):897-909.e7. doi: 10.1016/j.chembiol.2021.08.013. Epub 2021 Oct 1. PMID: 34599874; PMCID: PMC9252067.