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MedKoo Cat#: 329002 | Name: Edrophonium Chloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Edrophonium Chloride, also known as Tensilon, is an acetylcholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. Edrophonium Chloride has also been used as an antidote to curare principles.

Chemical Structure

Edrophonium Chloride
Edrophonium Chloride
CAS#116-38-1 (chloride)

Theoretical Analysis

MedKoo Cat#: 329002

Name: Edrophonium Chloride

CAS#: 116-38-1 (chloride)

Chemical Formula: C10H16ClNO

Exact Mass: 201.0920

Molecular Weight: 201.69

Elemental Analysis: C, 59.55; H, 8.00; Cl, 17.58; N, 6.94; O, 7.93

Price and Availability

Size Price Availability Quantity
100mg USD 250.00 2 Weeks
250mg USD 450.00 2 Weeks
1g USD 850.00 2 Weeks
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Related CAS #
312-48-1 (cation) 116-38-1 (chloride)
Synonym
Edrophonium Chloride; Tensilon; Tensilon chloride; Antirex; Enlon; Reversol; NSC-759577; NSC759577; NSC 759577
IUPAC/Chemical Name
N-ethyl-3-hydroxy-N,N-dimethylbenzenaminium chloride
InChi Key
BXKDSDJJOVIHMX-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H15NO.ClH/c1-4-11(2,3)9-6-5-7-10(12)8-9;/h5-8H,4H2,1-3H3;1H
SMILES Code
C[N+](C)(CC)C1=CC=CC(O)=C1.[Cl-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 201.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bassotti G, Imbimbo BP, Betti C, Erbella GS, Pelli MA, Morelli A. Edrophonium chloride for testing colonic contractile activity in man. Acta Physiol Scand. 1991 Mar;141(3):289-93. doi: 10.1111/j.1748-1716.1991.tb09083.x. PMID: 1858502. 2: Luo C, Saxena A, Ashani Y, Leader H, Radić Z, Taylor P, Doctor BP. Role of edrophonium in prevention of the re-inhibition of acetylcholinesterase by phosphorylated oxime. Chem Biol Interact. 1999 May 14;119-120:129-35. doi: 10.1016/s0009-2797(99)00021-6. PMID: 10421446. 3: Rossen RM, Krikorian J, Hancock EW. Ventricular asystole after edrophonium chloride administration. JAMA. 1976 Mar 8;235(10):1041-2. PMID: 765513. 4: Ludwig S, Bristow G. Hazards of edrophonium. Anesthesiology. 1979 Dec;51(6):567. doi: 10.1097/00000542-197912000-00022. PMID: 517789. 5: Shetisky GM, Shuster J. Ataxia telangiectasia. Henry Ford Hosp Med J. 1967 Mar;15(1):27-31. PMID: 6040056. 6: Domanovits H, Wenger S, Schillinger M, Mayr N, Holzer M, Laggner AN, Zeitlhofer J. Der Edrophonium-Chlorid (Tensilon)-Test: Ein sichere Methode in der Diagnostik der Myasthenia gravis [Edrophonium chloride (Tensilon) test: a safe method in diagnosing myasthenia gravis]. Wien Klin Wochenschr. 2000 Jul 7;112(13):592-5. German. PMID: 10944818. 7: Gustafsson U, Tibbling L. The effect of edrophonium chloride-induced chest pain on esophageal blood flow and motility. Scand J Gastroenterol. 1997 Feb;32(2):104-7. doi: 10.3109/00365529709000178. PMID: 9051868. 8: Magyar P, Szathmáry I, Szobor A. Myasthenia gravis: lung-function studies without and with edrophonium chloride. Eur Neurol. 1979;18(1):59-65. doi: 10.1159/000115054. PMID: 436864. 9: Matsumoto S, Murakami N, Koizumi H, Takahashi M, Izumi Y, Kaji R. Evaluation of the Edrophonium Challenge Test for Cervical Dystonia. Intern Med. 2017 Sep 15;56(18):2415-2421. doi: 10.2169/internalmedicine.8555-16. Epub 2017 Aug 21. PMID: 28824069; PMCID: PMC5643167. 10: MOORE H. Advantages of pyridostigmine bromide (mestinon) and edrophonium chloride (tensilon) in the treatment of transitory myasthenia gravis in the neonatal period. N Engl J Med. 1955 Dec 15;253(24):1075-6. doi: 10.1056/NEJM195512152532406. PMID: 13272842. 11: Smith JL. Myasthenia gravis and Charcot-Marie-Tooth disease. J Clin Neuroophthalmol. 1985 Jun;5(2):73-5. doi: 10.3109/01658108509014425. PMID: 2947919. 12: Osserman KE, Genkins G. Critical reappraisal of the use of edrophonium (tensilon) chloride tests in myasthenia gravis and significance of clinical classification. Ann N Y Acad Sci. 1966 Jan 26;135(1):312-34. doi: 10.1111/j.1749-6632.1966.tb45479.x. PMID: 5221347. 13: Ting CK, Lin SM, Yang YW, Tsai HJ, Lao HC, Chu YC, Tsai SK. Reversal of mivacurium chloride: edrophonium of spontaneous recovery in microscopic laryngeal surgery. Acta Anaesthesiol Sin. 2001 Dec;39(4):157-62. PMID: 11840581. 14: Gorelick PB. Office Tensilon test. Arch Neurol. 1987 Jul;44(7):689-90. doi: 10.1001/archneur.1987.00520190005002. PMID: 3593054. 15: Lee CA, Reynolds JC, Ouyang A, Baker L, Cohen S. Esophageal chest pain. Value of high-dose provocative testing with edrophonium chloride in patients with normal esophageal manometries. Dig Dis Sci. 1987 Jul;32(7):682-8. doi: 10.1007/BF01296132. PMID: 3595381. 16: Matsuura H, Sogabe Y, Matsuura H. Tensilon test: myasthenia gravis. QJM. 2019 Jan 1;112(1):49. doi: 10.1093/qjmed/hcy173. PMID: 30085301. 17: Szathmáry I, Magyar P, Szobor A. Myasthenia gravis: protective effect of ipratropiumbromide (Atrovent) on airways obstruction caused by edrophonium chloride (Tensilon). Eur Neurol. 1981;20(1):56-61. doi: 10.1159/000115206. PMID: 6451430. 18: Katz NK, Barohn RJ. The history of acetylcholinesterase inhibitors in the treatment of myasthenia gravis. Neuropharmacology. 2021 Jan;182:108303. doi: 10.1016/j.neuropharm.2020.108303. Epub 2020 Sep 9. PMID: 32918950. 19: ZELDOWICZ LR, BUCKLER WS. MYASTHENIA GRAVIS: MEDICAL ASPECTS. Can Med Assoc J. 1965 Jul 31;93(5):189-97. PMID: 14323662; PMCID: PMC1928601. 20: Pitt B, Kurland GS. Use of edrophonium chloride (tensilon) to detect early digitalis toxicity. Am J Cardiol. 1966 Oct;18(4):557-65. doi: 10.1016/0002-9149(66)90011-7. PMID: 5923983.