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MedKoo Cat#: 584383 | Name: Edrophonium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Edrophonium is a rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.

Chemical Structure

Edrophonium
Edrophonium
CAS#312-48-1 (cation)

Theoretical Analysis

MedKoo Cat#: 584383

Name: Edrophonium

CAS#: 312-48-1 (cation)

Chemical Formula: C10H16NO+

Exact Mass: 166.1226

Molecular Weight: 166.24

Elemental Analysis: C, 72.25; H, 9.70; N, 8.43; O, 9.62

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
312-48-1 (cation) 116-38-1 (chloride)
Synonym
Edrophonium; Edrophonum; Tensilon; EDROPHONIUM ION;
IUPAC/Chemical Name
Benzenaminium, N-ethyl-3-hydroxy-N,N-dimethyl-
InChi Key
VWLHWLSRQJQWRG-UHFFFAOYSA-O
InChi Code
InChI=1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1
SMILES Code
C[N+](C)(CC)C1=CC=CC(O)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 166.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Neostigmine-based reversal of intermediate acting neuromuscular blocking agents to prevent postoperative residual paralysis: A systematic review. Eur J Anaesthesiol. 2018 Mar;35(3):184-192. doi: 10.1097/EJA.0000000000000741. PubMed PMID: 29189420. 5: Choudhry SA, Anwar MJ, Afzal M, Shah A. Foodborne Botulism, I Only Had Nacho Cheese: A Case Report. Cureus. 2017 Sep 8;9(9):e1666. doi: 10.7759/cureus.1666. PubMed PMID: 29152423; PubMed Central PMCID: PMC5677338. 6: Blakey TJ, Michaels JR, Guo LT, Hodshon AJ, Shelton GD. Congenital Myasthenic Syndrome in a Mixed Breed Dog. Front Vet Sci. 2017 Oct 17;4:173. doi: 10.3389/fvets.2017.00173. eCollection 2017. PubMed PMID: 29090216; PubMed Central PMCID: PMC5650981. 7: Romano M, Martin-Flores M, Sakai DM, Tseng CT, Campoy L, Gleed RD. Effects of neostigmine or edrophonium on force of contraction when administered at a train-of-four ratio of 0.9 in anesthetized dogs. Vet Anaesth Analg. 2017 Nov;44(6):1313-1320. doi: 10.1016/j.vaa.2017.07.001. Epub 2017 Aug 3. PubMed PMID: 29066245. 8: Roper J, Fleming ME, Long B, Koyfman A. Myasthenia Gravis and Crisis: Evaluation and Management in the Emergency Department. J Emerg Med. 2017 Dec;53(6):843-853. doi: 10.1016/j.jemermed.2017.06.009. Epub 2017 Sep 12. PubMed PMID: 28916122. 9: Chinnadurai RK, Saravanaraman P, Boopathy R. The significance of aryl acylamidase activity of acetylcholinesterase in osteoblast differentiation and mineralization. Mol Cell Biochem. 2018 Mar;440(1-2):199-208. doi: 10.1007/s11010-017-3167-x. Epub 2017 Aug 29. PubMed PMID: 28852920. 10: Matsumoto S, Murakami N, Koizumi H, Takahashi M, Izumi Y, Kaji R. Evaluation of the Edrophonium Challenge Test for Cervical Dystonia. Intern Med. 2017 Sep 15;56(18):2415-2421. doi: 10.2169/internalmedicine.8555-16. Epub 2017 Aug 21. PubMed PMID: 28824069; PubMed Central PMCID: PMC5643167. 11: Mittal RK, Zifan A, Kumar D, Ledgerwood-Lee M, Ruppert E, Ghahremani G. Functional morphology of the lower esophageal sphincter and crural diaphragm determined by three-dimensional high-resolution esophago-gastric junction pressure profile and CT imaging. Am J Physiol Gastrointest Liver Physiol. 2017 Sep 1;313(3):G212-G219. doi: 10.1152/ajpgi.00130.2017. Epub 2017 Jun 1. PubMed PMID: 28572086; PubMed Central PMCID: PMC5625133. 12: Fukatsu M, Murakami T, Ohkawara H, Saito S, Ikeda K, Kadowaki S, Sasaki I, Segawa M, Soeda T, Hoshi A, Takahashi H, Shichishima-Nakamura A, Ogawa K, Sugiura Y, Ohto H, Takeishi Y, Ikezoe T, Ugawa Y. A possible role of low regulatory T cells in anti-acetylcholine receptor antibody positive myasthenia gravis after bone marrow transplantation. BMC Neurol. 2017 May 15;17(1):93. doi: 10.1186/s12883-017-0881-7. PubMed PMID: 28506261; PubMed Central PMCID: PMC5433011. 13: Tsunoda K, Fujimaki Y, Morita Y. Detectable voice change with the edrophonium test in laryngeal myasthenia gravis. J Int Med Res. 2017 Oct;45(5):1466-1469. doi: 10.1177/0300060516685026. Epub 2017 Jan 30. PubMed PMID: 28379106; PubMed Central PMCID: PMC5718711. 14: Faiz MA, Ahsan MF, Ghose A, Rahman MR, Amin R, Hossain M, Tareq MNU, Jalil MA, Kuch U, Theakston RDG, Warrell DA, Harris JB. Bites by the Monocled Cobra, Naja kaouthia, in Chittagong Division, Bangladesh: Epidemiology, Clinical Features of Envenoming and Management of 70 Identified Cases. Am J Trop Med Hyg. 2017 Apr;96(4):876-884. doi: 10.4269/ajtmh.16-0842. Epub 2017 Jan 30. PubMed PMID: 28138054; PubMed Central PMCID: PMC5392636. 15: Hagstrom D, Hirokawa H, Zhang L, Radic Z, Taylor P, Collins ES. Planarian cholinesterase: in vitro characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity and reactivation. Arch Toxicol. 2017 Aug;91(8):2837-2847. doi: 10.1007/s00204-016-1908-3. Epub 2016 Dec 18. PubMed PMID: 27990564. 16: Hardy TA, Lee AW, Yiannikas C, Chen CS, Reddel SW. Extensive Postradiation Ocular and Diffuse Cranial Neuromyotonia Mimicking Myasthenia Gravis. Neurologist. 2016 Sep;21(5):79-82. doi: 10.1097/NRL.0000000000000088. PubMed PMID: 27564076. 17: Guterman EL, Botelho JV, Horton JC. Diagnosis of Tensilon-Negative Ocular Myasthenia Gravis By Daily Selfie. J Neuroophthalmol. 2016 Sep;36(3):292-3. doi: 10.1097/WNO.0000000000000413. PubMed PMID: 27529328; PubMed Central PMCID: PMC5120673. 18: Tanaka Y, Satomi K. Overlap of Myasthenia Gravis and Miller Fisher Syndrome. Intern Med. 2016;55(14):1917-8. doi: 10.2169/internalmedicine.55.6262. Epub 2016 Jul 15. PubMed PMID: 27432103. 19: Matsumoto S, Murakami N, Koizumi H, Takahashi M, Izumi Y, Kaji R. Edrophonium Challenge Test for Blepharospasm. Front Neurosci. 2016 Jun 6;10:226. doi: 10.3389/fnins.2016.00226. eCollection 2016. PubMed PMID: 27375406; PubMed Central PMCID: PMC4894005. 20: Kroczka S, Stasiak K, Kaciński M. [Neurophysiological parameters in myasthena gravis in children in diagnostic and therapeutic view]. Przegl Lek. 2016;73(3):119-23. Polish. PubMed PMID: 27349037.