Fentiazac | BR-700 | CAS#18046-21-4 | Non-Steroidal Anti-Inflammatory

MedKoo Cat#: 328905 | Name: Fentiazac

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fentiazac, also known as BR-700, is a non-steroidal anti-inflammatory agent used to treat inflammation and pain.

Chemical Structure

Fentiazac

CAS#18046-21-4 (free acid)

Theoretical Analysis

MedKoo Cat#: 328905

Name: Fentiazac

CAS#: 18046-21-4 (free acid)

Chemical Formula: C17H12ClNO2S

Exact Mass: 329.0277

Molecular Weight: 329.80

Elemental Analysis: C, 61.91; H, 3.67; Cl, 10.75; N, 4.25; O, 9.70; S, 9.72

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

85721-24-0 (calcium) 96593-16-7 (sodium) 18046-21-4 (free acid)

Synonym

Fentiazac; BR-700; BR-700; BR-700; CH800; CH-800; CH 800; NSC 282191; WY-21,894; WY21,894; WY 21,894; WY-21894; WY21894; WY 21894; Norvedan; Donorest; Flogene

IUPAC/Chemical Name

2-(4-(4-chlorophenyl)-2-phenylthiazol-5-yl)acetic acid

InChi Key

JIEKMACRVQTPRC-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H12ClNO2S/c18-13-8-6-11(7-9-13)16-14(10-15(20)21)22-17(19-16)12-4-2-1-3-5-12/h1-9H,10H2,(H,20,21)

SMILES Code

O=C(O)CC1=C(C2=CC=C(Cl)C=C2)N=C(C3=CC=CC=C3)S1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 329.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Dowell PS, Pierce DM, Franklin RA, Norris R, Harries H, Whiteland H. The pharmacokinetics of fentiazac and its metabolite, p-hydroxyfentiazac, after twice-daily oral administration to male volunteers. Xenobiotica. 1984 Dec;14(12):947-53. PubMed PMID: 6531942. 2: Chang J, Carlson RP, Lewis AJ. A comparative study of the antiinflammatory activity of fentiazac and its major metabolite, p-hydroxy fentiazac. Agents Actions. 1984 Oct;15(3-4):443-7. PubMed PMID: 6441470. 3: Bunde B, Deckers Y, Dequeker J. Fentiazac in rheumatoid arthritis: comparison with sulindac and long-term tolerance. Curr Med Res Opin. 1983;8(5):310-4. PubMed PMID: 6340972. 4: Leguen MA. Single-blind clinical trial comparing use of fentiazac and paracetamol in postendodontic periodontitis. Clin Ther. 1985;7(2):145-50. PubMed PMID: 3886139. 5: Thumb N, Kolarz G, Scherak O, Mayrhofer F. The efficacy and safety of fentiazac and diclofenac sodium in peri-arthritis of the shoulder: a multi-centre, double-blind comparison. J Int Med Res. 1987 Nov-Dec;15(6):327-34. PubMed PMID: 3325316. 6: Catti A. Controlled clinical study with Fentiazac suspension in painful inflammatory diseases of children. J Int Med Res. 1983;11(5):298-302. PubMed PMID: 6605890. 7: Famaey JP, Gaci O, Ginsberg F. Fentiazac in the treatment of osteoarthritis and tendinitis. Curr Med Res Opin. 1983;8(9):675-81. PubMed PMID: 6365468. 8: Fumero S, Mondino A, Silvestri S, Zanolo G, De Marchi G, Pedrazzini S. Metabolism of fentiazac. Arzneimittelforschung. 1980;30(8):1253-6. PubMed PMID: 7192138. 9: López Rosales C, Cisneros Lugo JH, Romo Enciso LJ, García Sandoval MG. [Nimesulide in the treatment of primary dysmenorrhea. Comparative clinical evaluation with mefenamic acid and fentiazac]. Ginecol Obstet Mex. 1989 Jul;57:196-201. Spanish. PubMed PMID: 2486951. 10: López JM. Treatment of acute tendinitis and bursitis with fentiazac--a double-blind comparison with placebo. Clin Ther. 1982;5(1):79-84. PubMed PMID: 6751536. 11: Zanolo G, Giachetti C, Mondino A, Silvestri S, Bianchi E, Segre G, Gomarasca P, De Marchi G. Pharmacokinetics of fentiazac in rats and monkeys. Arzneimittelforschung. 1981;31(7):1098-104. PubMed PMID: 7196759. 12: Shimura K, Oto A, Hanai Y, Watanabe S, Toda M, Asada K, Ishibashi K, Shimabukuro Y, Yokochi N, Shiramizu H, Fuse T, Saeki T, Hayakawa T. Analgesic effect of fentiazac after tooth extraction or minor oral surgery. Clin Ther. 1981;4(1):12-7. PubMed PMID: 6974045. 13: Pacheco D, Roman O, González M, Román M. [Piroxicam and fentiazac do not change the arterial pressure in hypertensives patients undergoing treatment]. Rev Med Chil. 1989 Oct;117(10):1150-3. Spanish. PubMed PMID: 2519359. 14: Franklin RA, Norris R, Shepherd NW, Rhenius ST. Preliminary studies on the fate of 14C-fentiazac in man. Xenobiotica. 1984 Dec;14(12):956-60. PubMed PMID: 6531943. 15: Francisco JV. Fentiazac as an oral analgesic for postoperative dental pain. Clin Ther. 1984;6(6):787-92. PubMed PMID: 6334555.