Synonym
ATB-352; ATB352; ATB 352;
IUPAC/Chemical Name
4-carbamothioylphenyl 2-(3-benzoylphenyl)propanoate
InChi Key
GSBVBIPAZXAIBP-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H19NO3S/c1-15(23(26)27-20-12-10-17(11-13-20)22(24)28)18-8-5-9-19(14-18)21(25)16-6-3-2-4-7-16/h2-15H,1H3,(H2,24,28)
SMILES Code
O=C(C1=CC=CC(C(C)C(OC2=CC=C(C(N)=S)C=C2)=O)=C1)C3=CC=CC=C3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
389.47
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Kuczyńska J, Nieradko-Iwanicka B. Future prospects of ketoprofen in improving the safety of the gastric mucosa. Biomed Pharmacother. 2021 Jul;139:111608. doi: 10.1016/j.biopha.2021.111608. Epub 2021 Apr 28. PMID: 33932737.
2: Głowacka U, Magierowska K, Wójcik D, Hankus J, Szetela M, Cieszkowski J, Korbut E, Danielak A, Surmiak M, Chmura A, Wallace JL, Magierowski M. Microbiome Profile and Molecular Pathways Alterations in Gastrointestinal Tract by Hydrogen Sulfide-Releasing Nonsteroidal Anti-Inflammatory Drug (ATB-352): Insight into Possible Safer Polypharmacy. Antioxid Redox Signal. 2021 Apr 12. doi: 10.1089/ars.2020.8240. Epub ahead of print. PMID: 33678013.
3: Costa SKPF, Muscara MN, Allain T, Dallazen J, Gonzaga L, Buret AG, Vaughan DJ, Fowler CJ, de Nucci G, Wallace JL. Enhanced Analgesic Effects and Gastrointestinal Safety of a Novel, Hydrogen Sulfide-Releasing Anti-Inflammatory Drug (ATB-352): A Role for Endogenous Cannabinoids. Antioxid Redox Signal. 2020 Nov 10;33(14):1003-1009. doi: 10.1089/ars.2019.7884. Epub 2020 Mar 13. PMID: 32064887; PMCID: PMC7578177.
4: Thibault MP, Tremblay É, Wallace JL, Beaulieu JF. Effect of Ketoprofen and ATB-352 on the Immature Human Intestine: Identification of Responders and Non- responders. J Pediatr Gastroenterol Nutr. 2019 May;68(5):623-629. doi: 10.1097/MPG.0000000000002308. PMID: 31022092; PMCID: PMC6510328.
5: Gugliandolo E, Fusco R, D'Amico R, Militi A, Oteri G, Wallace JL, Di Paola R, Cuzzocrea S. Anti-inflammatory effect of ATB-352, a H2S -releasing ketoprofen derivative, on lipopolysaccharide-induced periodontitis in rats. Pharmacol Res. 2018 Jun;132:220-231. doi: 10.1016/j.phrs.2017.12.022. Epub 2017 Dec 26. PMID: 29287688.
