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MedKoo Cat#: 591359 | Name: AG 30
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

An antimicrobial peptide with angiogenic properties, AG-30/5C, activates human mast cells through the MAPK and NF-κB pathways.

Chemical Structure

AG 30
CAS#122520-79-0

Theoretical Analysis

MedKoo Cat#: 591359

Name: AG 30

CAS#: 122520-79-0

Chemical Formula: C10H7NO4

Exact Mass: 205.0375

Molecular Weight: 205.17

Elemental Analysis: C, 58.54; H, 3.44; N, 6.83; O, 31.19

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
25mg USD 650.00 2 Weeks
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Related CAS #
No Data
Synonym
AG 30; AG-30; AG30; Tyrphostin AG30;
IUPAC/Chemical Name
2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (E)-
InChi Key
CJMWBHLWSMKFSM-XVNBXDOJSA-N
InChi Code
InChI=1S/C10H7NO4/c11-5-7(10(14)15)3-6-1-2-8(12)9(13)4-6/h1-4,12-13H,(H,14,15)/b7-3+
SMILES Code
O=C(O)/C(C#N)=C/C1=CC=C(O)C(O)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 205.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Roy S, Ganguly A, Haque M, Ali H. Angiogenic Host Defense Peptide AG-30/5C and Bradykinin B2 Receptor Antagonist Icatibant Are G Protein Biased Agonists for MRGPRX2 in Mast Cells. J Immunol. 2019 Feb 15;202(4):1229-1238. doi: 10.4049/jimmunol.1801227. Epub 2019 Jan 16. PMID: 30651343; PMCID: PMC6369923. 2: Kiatsurayanon C, Niyonsaba F, Chieosilapatham P, Okumura K, Ikeda S, Ogawa H. Angiogenic peptide (AG)-30/5C activates human keratinocytes to produce cytokines/chemokines and to migrate and proliferate via MrgX receptors. J Dermatol Sci. 2016 Sep;83(3):190-9. doi: 10.1016/j.jdermsci.2016.05.006. Epub 2016 May 11. PMID: 27237787. 3: Kanazawa K, Okumura K, Ogawa H, Niyonsaba F. An antimicrobial peptide with angiogenic properties, AG-30/5C, activates human mast cells through the MAPK and NF-κB pathways. Immunol Res. 2016 Apr;64(2):594-603. doi: 10.1007/s12026-015-8759-5. PMID: 26663017. 4: Nishikawa T, Nakagami H, Maeda A, Morishita R, Miyazaki N, Ogawa T, Tabata Y, Kikuchi Y, Hayashi H, Tatsu Y, Yumoto N, Tamai K, Tomono K, Kaneda Y. Development of a novel antimicrobial peptide, AG-30, with angiogenic properties. J Cell Mol Med. 2009 Mar;13(3):535-46. doi: 10.1111/j.1582-4934.2008.00341.x. Epub 2008 Apr 9. PMID: 18410525; PMCID: PMC3822513. 5: Olsen JR, Dehdashti F, Siegel BA, Zighelboim I, Grigsby PW, Schwarz JK. Prognostic utility of squamous cell carcinoma antigen in carcinoma of the cervix: association with pre- and posttreatment FDG-PET. Int J Radiat Oncol Biol Phys. 2011 Nov 1;81(3):772-7. doi: 10.1016/j.ijrobp.2010.06.008. Epub 2010 Oct 1. PMID: 20888130. 6: Carlson C, Hussain SM, Schrand AM, Braydich-Stolle LK, Hess KL, Jones RL, Schlager JJ. Unique cellular interaction of silver nanoparticles: size-dependent generation of reactive oxygen species. J Phys Chem B. 2008 Oct 30;112(43):13608-19. doi: 10.1021/jp712087m. Epub 2008 Oct 3. PMID: 18831567. 7: De Souza LR, Jenkins AL, Jovanovski E, Rahelić D, Vuksan V. Ethanol extraction preparation of American ginseng (Panax quinquefolius L) and Korean red ginseng (Panax ginseng C.A. Meyer): differential effects on postprandial insulinemia in healthy individuals. J Ethnopharmacol. 2015 Jan 15;159:55-61. doi: 10.1016/j.jep.2014.10.057. Epub 2014 Nov 4. PMID: 25446600. 8: Ragland TJ, Malin SK. Plasma LEAP-2 Following a Low-Calorie Diet with or without Interval Exercise in Women with Obesity. Nutrients. 2023 Jan 28;15(3):655. doi: 10.3390/nu15030655. PMID: 36771362; PMCID: PMC9918887. 9: Firouzjaei MA, Jafari MR, Eskandari M, Anarkoli IJ, Alipour M. Aminoguanidine changes hippocampal expression of apoptosis-related genes, improves passive avoidance learning and memory in streptozotocin-induced diabetic rats. Cell Mol Neurobiol. 2014 Apr;34(3):343-50. doi: 10.1007/s10571-013-0018-5. Epub 2013 Dec 11. PMID: 24326522. 10: Gauna C, Kiewiet RM, Janssen JA, van de Zande B, Delhanty PJ, Ghigo E, Hofland LJ, Themmen AP, van der Lely AJ. Unacylated ghrelin acts as a potent insulin secretagogue in glucose-stimulated conditions. Am J Physiol Endocrinol Metab. 2007 Sep;293(3):E697-704. doi: 10.1152/ajpendo.00219.2007. Epub 2007 Jun 19. PMID: 17578884. 11: Fahlén-Yrlid L, Gustafsson T, Westlund J, Holmberg A, Strömbeck A, Blomquist M, MacPherson GG, Holmgren J, Yrlid U. CD11c(high )dendritic cells are essential for activation of CD4+ T cells and generation of specific antibodies following mucosal immunization. J Immunol. 2009 Oct 15;183(8):5032-41. doi: 10.4049/jimmunol.0803992. Epub 2009 Sep 28. PMID: 19786541. 12: Correia AG, Denton KM, Evans RG. Effects of activation of vasopressin-V1-receptors on regional kidney blood flow and glomerular arteriole diameters. J Hypertens. 2001 Mar;19(3 Pt 2):649-57. doi: 10.1097/00004872-200103001-00019. PMID: 11327642. 13: Najafi S, Hadinedoushan H, Eslami G, Aflatoonian A. Association of IL-17A and IL-17 F gene polymorphisms with recurrent pregnancy loss in Iranian women. J Assist Reprod Genet. 2014 Nov;31(11):1491-6. doi: 10.1007/s10815-014-0294-0. Epub 2014 Sep 17. PMID: 25227691; PMCID: PMC4389929. 14: Baskin F, Smith GM, Fosmire JA, Rosenberg RN. Altered apolipoprotein E secretion in cytokine treated human astrocyte cultures. J Neurol Sci. 1997 May 1;148(1):15-8. doi: 10.1016/s0022-510x(96)05335-x. PMID: 9125385.