LC-MF-4 | an efficient FGFR3 degrader

MedKoo Cat#: 129082 | Name: LC-MF-4

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LC-MF-4 is an efficient FGFR3 degrader, for the treatment of cancers harboring FGFR3 alterations. Proteomic analysis revealed that LC-MF-4 exhibits exceptional proteomic selectivity for FGFR3 degradation. In FGFR3-TACC3 fusion-positive cells, LC-MF-4 exerted its effects by suppressing the expression of genes involved in mitochondrial biogenesis and ATP synthesis.

Chemical Structure

LC-MF-4

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 129082

Name: LC-MF-4

CAS#: N/A

Chemical Formula: C55H68Cl2FN11O8S

Exact Mass: 1131.4334

Molecular Weight: 1133.18

Elemental Analysis: C, 58.30; H, 6.05; Cl, 6.26; F, 1.68; N, 13.60; O, 11.29; S, 2.83

Price and Availability

Related CAS #

No Data

Synonym

LC-MF-4; LC-MF4; LCMF-4; LCMF4

IUPAC/Chemical Name

(2R,4S)-N-(2-((5-(4-(4-((6-(3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-methylureido)pyrimidin-4-yl)amino)phenyl)piperazin-1-yl)pentyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((R)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide

InChi Key

TUEFAPYHYUOYNL-VAVBZHECSA-N

InChi Code

InChI=1S/C55H68Cl2FN11O8S/c1-33-48(78-32-62-33)34-11-12-35(29-59-50(71)39-26-38(70)30-69(39)51(72)49(54(2,3)4)65-52(73)55(58)17-18-55)40(25-34)77-24-10-8-9-19-67-20-22-68(23-21-67)37-15-13-36(14-16-37)63-43-28-44(61-31-60-43)66(5)53(74)64-47-45(56)41(75-6)27-42(76-7)46(47)57/h11-16,25,27-28,31-32,38-39,49,70H,8-10,17-24,26,29-30H2,1-7H3,(H,59,71)(H,64,74)(H,65,73)(H,60,61,63)/t38-,39+,49-/m0/s1

SMILES Code

COC1=CC(OC)=C(Cl)C(NC(N(C)C2=NC=NC(NC3=CC=C(N4CCN(CCCCCOC5=CC(C6=C(C)N=CS6)=CC=C5CNC([C@@H]7N(C([C@@H](C(C)(C)C)NC(C8(F)CC8)=O)=O)C[C@@H](O)C7)=O)CC4)C=C3)=C2)=O)=C1Cl

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Biological target:

In vitro activity:

In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,133.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

In vitro protocol:

In vivo protocol:

Zheng L, Cao J, Ma L, Chen S, Cao X, Luo R, Wang Y, Ke D, Huang P, Liang G, Chen L. LC-MF-4, a Novel FGFR3 Degrader for Therapeutic Intervention in FGFR3-Altered Cancers. J Med Chem. 2025 Jun 27. doi: 10.1021/acs.jmedchem.5c00731. Epub ahead of print. PMID: 40575843.