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MedKoo Cat#: 584250 | Name: Fentiazac sodium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fentiazac, also known as BR-700, is a non-steroidal anti-inflammatory agent used to treat inflammation and pain.

Chemical Structure

Fentiazac sodium
Fentiazac sodium
CAS#96593-16-7 (sodium)

Theoretical Analysis

MedKoo Cat#: 584250

Name: Fentiazac sodium

CAS#: 96593-16-7 (sodium)

Chemical Formula: 17H11ClNNaO2S

Exact Mass: 329.0277

Molecular Weight: 351.78

Elemental Analysis: C, 58.04; H, 3.15; Cl, 10.08; N, 3.98; Na, 6.54; O, 9.10; S, 9.11

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
85721-24-0 (calcium) 96593-16-7 (sodium) 18046-21-4 (free acid)
Synonym
Fentiazac sodium; Fentiazac; BR-700; BR-700; BR-700; CH800; CH-800; CH 800; NSC 282191; WY-21,894; WY21,894; WY 21,894; WY-21894; WY21894; WY 21894; Norvedan; Donorest; Flogene
IUPAC/Chemical Name
5-Thiazoleacetic acid, 4-(p-chlorophenyl)-2-phenyl-, sodium salt
InChi Key
BGPAPLSVPJLNMH-UHFFFAOYSA-M
InChi Code
InChI=1S/C17H12ClNO2S.Na/c18-13-8-6-11(7-9-13)16-14(10-15(20)21)22-17(19-16)12-4-2-1-3-5-12;/h1-9H,10H2,(H,20,21);/q;+1/p-1
SMILES Code
O=C([O-])CC1=C(C2=CC=C(Cl)C=C2)N=C(C3=CC=CC=C3)S1.[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 351.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Famaey JP, Gaci O, Ginsberg F. Fentiazac in the treatment of osteoarthritis and tendinitis. Curr Med Res Opin. 1983;8(9):675-81. PubMed PMID: 6365468. 2: Nagatomi H, Ando K. Studies on the anti-inflammatory activity and ulcerogenic adverse effect of thiazole derivatives, especially 2-amino-thiazoleacetic acid derivatives. Arzneimittelforschung. 1984;34(5):599-603. PubMed PMID: 6540578. 3: Catti A. Controlled clinical study with Fentiazac suspension in painful inflammatory diseases of children. J Int Med Res. 1983;11(5):298-302. PubMed PMID: 6605890. 4: Houin G, Lapeyre C, Rochas MA, Tufenkji AE, Campistron G, Coulais Y, Akbaraly JP, Grislain L, Beck H. Pharmacokinetic study of fentiazac and its main metabolite hydroxyfentiazac in the elderly. Arzneimittelforschung. 1993 Jan;43(1):50-3. PubMed PMID: 8447848. 5: Shimura K, Oto A, Hanai Y, Watanabe S, Toda M, Asada K, Ishibashi K, Shimabukuro Y, Yokochi N, Shiramizu H, Fuse T, Saeki T, Hayakawa T. Analgesic effect of fentiazac after tooth extraction or minor oral surgery. Clin Ther. 1981;4(1):12-7. PubMed PMID: 6974045. 6: López Rosales C, Cisneros Lugo JH, Romo Enciso LJ, García Sandoval MG. [Nimesulide in the treatment of primary dysmenorrhea. Comparative clinical evaluation with mefenamic acid and fentiazac]. Ginecol Obstet Mex. 1989 Jul;57:196-201. Spanish. PubMed PMID: 2486951. 7: Ginsberg F, Famaey JP. A double-blind comparison of slow-release and standard tablet formulations of fentiazac in the treatment of patients with tendinitis and bursitis. Curr Med Res Opin. 1985;9(7):442-8. PubMed PMID: 4028807. 8: Bunde B, Deckers Y, Dequeker J. Fentiazac in rheumatoid arthritis: comparison with sulindac and long-term tolerance. Curr Med Res Opin. 1983;8(5):310-4. PubMed PMID: 6340972. 9: Thumb N, Kolarz G, Scherak O, Mayrhofer F. The efficacy and safety of fentiazac and diclofenac sodium in peri-arthritis of the shoulder: a multi-centre, double-blind comparison. J Int Med Res. 1987 Nov-Dec;15(6):327-34. PubMed PMID: 3325316. 10: López JM. Treatment of acute tendinitis and bursitis with fentiazac--a double-blind comparison with placebo. Clin Ther. 1982;5(1):79-84. PubMed PMID: 6751536. 11: Leguen MA. Single-blind clinical trial comparing use of fentiazac and paracetamol in postendodontic periodontitis. Clin Ther. 1985;7(2):145-50. PubMed PMID: 3886139. 12: Molina J. Fentiazac in acute gouty arthritis. Clin Ther. 1985;7(3):327-33. PubMed PMID: 3995528. 13: Rendina GM, Patrono D, Iansiti A. [The use of fentiazac in the therapy of primary dysmenorrhea]. Minerva Ginecol. 1982 May;34(5):395-400. Italian. PubMed PMID: 6982435. 14: Fumero S, Mondino A, Silvestri S, Zanolo G, De Marchi G, Pedrazzini S. Metabolism of fentiazac. Arzneimittelforschung. 1980;30(8):1253-6. PubMed PMID: 7192138. 15: Kweon DS, Shim CK, Lee MH. Effect of cimetidine on the pharmacokinetics of fentiazac in rats. J Pharm Sci. 1993 Sep;82(9):952-5. PubMed PMID: 8229695. 16: Fumero S, Mondino A, Silvestri S, Zanolo G, De Marchi G, Pedrazzini S. Binding of fentiazac to serum protein. Pharmacol Res Commun. 1980 Jan;12(1):41-8. PubMed PMID: 7384163. 17: Zanolo G, Giachetti C, Mondino A, Silvestri S, Bianchi E, Segre G, Gomarasca P, De Marchi G. Pharmacokinetics of fentiazac in rats and monkeys. Arzneimittelforschung. 1981;31(7):1098-104. PubMed PMID: 7196759. 18: Bex FJ, Corbin A. Cyclic response of hypophysectomized rats to ovulation induced by LHRH agonist: mediation by prostaglandins. Life Sci. 1984 Aug 27;35(9):969-79. PubMed PMID: 6433130. 19: de Menezes MR, Catanzaro-Guimarães SA. Determination of anti-inflammatory and antimitotic activities of non-steroid anti-inflammatory drugs ibuprofen, diclofenac sodium and fentiazac. Cell Mol Biol. 1985;31(6):455-61. PubMed PMID: 4075369. 20: Franklin RA, Norris R, Shepherd NW, Rhenius ST. Preliminary studies on the fate of 14C-fentiazac in man. Xenobiotica. 1984 Dec;14(12):956-60. PubMed PMID: 6531943.

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