Synonym
Clovoxamine fumarate; DU 23811; DU-23811; DU23811.
IUPAC/Chemical Name
4'-Chloro-5-methoxyvalerophenone (E)-O-(2-aminoethyl)oxime fumarate
InChi Key
HOFGGHPYWKSXTN-QCHLHFLZSA-N
InChi Code
InChI=1S/C14H21ClN2O2.C4H4O4/c1-18-10-3-2-4-14(17-19-11-9-16)12-5-7-13(15)8-6-12;5-3(6)1-2-4(7)8/h5-8H,2-4,9-11,16H2,1H3;1-2H,(H,5,6)(H,7,8)/b17-14+;2-1+
SMILES Code
COCCCC/C(C1=CC=C(Cl)C=C1)=N\OCCN.OC(/C=C/C(O)=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
400.86
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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7: Gelenberg AJ, Wojcik JD, Falk WE, Spring B, Brotman AW, Galvin-Nadeau M. Clovoxamine in the treatment of depressed outpatients: a double-blind, parallel-group comparison against amitriptyline and placebo. Compr Psychiatry. 1990 Jul-Aug;31(4):307-14. PubMed PMID: 2201481.
8: Strömberg C, Mattila MJ. Acute comparison of clovoxamine and mianserin, alone and in combination with ethanol, on human psychomotor performance. Pharmacol Toxicol. 1987 May;60(5):374-9. PubMed PMID: 3615347.
9: Minot R, Crocq MA, Roussel B, Marie-Cardine M. [Action of clovoxamine on the sleep of depressed patients. "Polygraphic recordings"]. Encephale. 1985 Mar-Apr;11(2):65-70. French. PubMed PMID: 4017939.
10: de Jong GJ. The use of a pre-column for the direct high-performance liquid chromatographic determination of the anti-depressants clovoxamine and fluvoxamine in plasma. J Chromatogr. 1980 Aug 8;183(2):203-11. PubMed PMID: 6772658.
