Synonym
Clovoxamine (free base); Clovoxaminum; Clovoxamina
IUPAC/Chemical Name
1-Pentanone, 1-(4-chlorophenyl)-5-methoxy-, O-(2-aminoethyl)oxime, (E)-
InChi Key
XXPVSQRPGBUFKM-SAPNQHFASA-N
InChi Code
InChI=1S/C14H21ClN2O2/c1-18-10-3-2-4-14(17-19-11-9-16)12-5-7-13(15)8-6-12/h5-8H,2-4,9-11,16H2,1H3/b17-14+
SMILES Code
COCCCC/C(C1=CC=C(Cl)C=C1)=N\OCCN
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
284.78
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Saletu B, Grünberger J, Rajna P, Karobath M. Clovoxamine and fluvoxamine-2 biogenic amine re-uptake inhibiting antidepressants: quantitative EEG, psychometric and pharmacokinetic studies in man. J Neural Transm. 1980;49(1-2):63-86. doi: 10.1007/BF01249190. PMID: 6777458.
2: Ochs HR, Greenblatt DJ, Verburg-Ochs B, Labedski L. Chronic treatment with fluvoxamine, clovoxamine, and placebo: interaction with digoxin and effects on sleep and alertness. J Clin Pharmacol. 1989 Jan;29(1):91-5. doi: 10.1002/j.1552-4604.1989.tb03243.x. PMID: 2496149.
3: Lodge GJ, Freeman HL. Clovoxamine and doxepin in major depressive disorder: a double-blind controlled trial. Br J Psychiatry. 1986 Jun;148:718-21. doi: 10.1192/bjp.148.6.718. PMID: 3535975.
4: Calanca A, Freeman HL, Hole G, Wakelin J. Clovoxamine: a new nontricylic antidepressant--a European multicenter initial study. Compr Psychiatry. 1983 Mar-Apr;24(2):179-82. doi: 10.1016/0010-440x(83)90106-2. PMID: 6342934.
5: Spring B, Gelenberg AJ, Garvin R, Thompson S. Amitriptyline, clovoxamine and cognitive function: a placebo-controlled comparison in depressed outpatients. Psychopharmacology (Berl). 1992;108(3):327-32. doi: 10.1007/BF02245119. PMID: 1523282.
6: Robinson JF, Doogan DP. A placebo controlled study of the cardiovascular effects of fluvoxamine and clovoxamine in human volunteers. Br J Clin Pharmacol. 1982 Dec;14(6):805-8. doi: 10.1111/j.1365-2125.1982.tb02040.x. PMID: 6817771; PMCID: PMC1427539.
7: Gelenberg AJ, Wojcik JD, Falk WE, Spring B, Brotman AW, Galvin-Nadeau M. Clovoxamine in the treatment of depressed outpatients: a double-blind, parallel- group comparison against amitriptyline and placebo. Compr Psychiatry. 1990 Jul- Aug;31(4):307-14. doi: 10.1016/0010-440x(90)90037-s. PMID: 2201481.
8: Jesinger DK, Gostick N. Anxiety neurosis in general practice. A double-blind comparative study of diazepam and clovoxamine, a novel inhibitor of noradrenaline and serotonin reuptake. Int Clin Psychopharmacol. 1989 Oct;4(4):301-11. doi: 10.1097/00004850-198910000-00005. PMID: 2691573.
9: de Jong GJ. The use of a pre-column for the direct high-performance liquid chromatographic determination of the anti-depressants clovoxamine and fluvoxamine in plasma. J Chromatogr. 1980 Aug 8;183(2):203-11. doi: 10.1016/s0378-4347(00)81694-1. PMID: 6772658.
10: Hurst HE, Jones DR, Wright JH, Jarboe CH. Clovoxamine kinetics in an early clinical trial. Clin Pharmacol Ther. 1983 Aug;34(2):266-71. doi: 10.1038/clpt.1983.164. PMID: 6872422.
