GS 283 | CAS#149440-36-8 | Ca(2+) antagonist

MedKoo Cat#: 525175 | Name: GS 283

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GS 283 is a Ca(2+) antagonist and a weak histamine & muscarinic receptor blocker in rat & guinea pig tracheal smooth muscles. Its mode of action is inhibition of calcium influx from plasma membrane & also release from sarcoplasmic reticulum.

Chemical Structure

GS 283

CAS#149440-36-8

Theoretical Analysis

MedKoo Cat#: 525175

Name: GS 283

CAS#: 149440-36-8

Chemical Formula: C17H15NO5

Exact Mass: 313.0950

Molecular Weight: 313.30

Elemental Analysis: C, 65.17; H, 4.83; N, 4.47; O, 25.53

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

GS 283; GS-283; GS283.

IUPAC/Chemical Name

1-(4'-Methoxybenzyl)-6,7-dihydroxy-3,4-dihydroxyisoquinoline

InChi Key

LBZFUYOFHYNWSE-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H15NO5/c1-23-10-4-2-9(3-5-10)6-13-11-7-14(19)15(20)8-12(11)16(21)17(22)18-13/h2-5,7-8,19-21H,6H2,1H3,(H,18,22)

SMILES Code

OC1=C(O)N=C(CC2=CC=C(OC)C=C2)C3=C1C=C(O)C(O)=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 313.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Chang KC, Ko HJ, Cho SD, Yoon YJ, Kim JH. Pharmacological characterization of effects of verapamil and GS 283 on isolated guinea pig and rat trachealis. Eur J Pharmacol. 1993 May 12;236(1):51-60. PubMed PMID: 8100527.