Technetium Tc 99m sestamibi | CAS# 109581-73-9 | imaging agent

MedKoo Cat#: 412350 | Name: Technetium Tc 99m sestamibi

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Technetium Tc 99m sestamibi is a technetium imaging agent used to reveal blood-starved cardiac tissue during a heart attack.

Chemical Structure

Technetium Tc 99m sestamibi

CAS#109581-73-9

Theoretical Analysis

MedKoo Cat#: 412350

Name: Technetium Tc 99m sestamibi

CAS#: 109581-73-9

Chemical Formula: C36H66N6O6Tc+

Exact Mass: 763.4528

Molecular Weight: 777.87

Elemental Analysis: C, 55.59; H, 8.55; N, 10.80; O, 12.34; Tc, 12.72

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Technetium Tc 99m sestamibi; RP30; RP-30; RP 30; TcMIBI; Tc-MIBI; Tc MIBI

IUPAC/Chemical Name

Technetium(1+)-(sup 99 m)Tc, hexakis(1-isocyano-2-methoxy-2-methylpropane)-, (OC-6-11)-

InChi Key

ZBTQTVSNLRPJHI-UHFFFAOYSA-N

InChi Code

InChI=1S/6C6H11NO.Tc/c6*1-6(2,8-4)5-7-3;/h6*5H2,1-2,4H3;/q;;;;;;+1

SMILES Code

COC(C)(C[N+]#[C-][Tc+]([C-]#[N+]CC(C)(OC)C)([C-]#[N+]CC(C)(OC)C)([C-]#[N+]CC(C)(OC)C)([C-]#[N+]CC(C)(OC)C)[C-]#[N+]CC(C)(OC)C)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

1: Bleier BS, LiVolsi VA, Chalian AA, Gimotty PA, Botbyl JD, Weber RS. Technetium Tc 99m sestamibi sensitivity in oxyphil cell-dominant parathyroid adenomas. Arch Otolaryngol Head Neck Surg. 2006 Jul;132(7):779-82. doi: 10.1001/archotol.132.7.779. PMID: 16847189. 2: Morita ET, Kwan WP, Clark OH. Technetium Tc 99m sestamibi for parathyroid imaging. West J Med. 1994 Oct;161(4):413. PMID: 7817557; PMCID: PMC1022628. 3: Mohan HK, Routledge T, Cane P, Livieratos L, Ballinger JR, Peters AM. Does the Clearance of Inhaled (99m)Tc-Sestamibi Correlate with Multidrug Resistance Protein 1 Expression in the Human Lung? Radiology. 2016 Sep;280(3):924-30. doi: 10.1148/radiol.16151389. Epub 2016 Mar 7. PMID: 26954010. 4: Arsos G, Kyparos A, Moralidis E, Kyparos D, Georga S, Sotiriadou S, Matziari C, Karakatsanis C. (99m)Tc-sestamibi uptake in rat skeletal muscle and heart: physiological determinants and correlations. Physiol Res. 2009;58(1):21-8. Epub 2008 Jan 17. PMID: 18198988. 5: Watanabe T, Monzen H, Hara M, Mizowaki T, Hiraoka M. Pharmacokinetic model of myocardial (99m)Tc-sestamibi washout. Ann Nucl Med. 2013 Apr;27(3):279-84. doi: 10.1007/s12149-013-0684-x. Epub 2013 Jan 24. PMID: 23344692. 6: Maucksch U, Runge R, Wunderlich G, Freudenberg R, Naumann A, Kotzerke J. Comparison of the radiotoxicity of the 99mTc-labeled compounds 99mTc-pertechnetate, 99mTc-HMPAO and 99mTc- MIBI. Int J Radiat Biol. 2016 Nov;92(11):698-706. doi: 10.3109/09553002.2016.1168533. Epub 2016 Apr 27. PMID: 27117205. 7: Zhou J, Lu DY, Xia L, Cheng XJ. Diagnosis performance of 99mTc- MIBI and multimodality imaging for hyperparathyroidism. J Huazhong Univ Sci Technolog Med Sci. 2017 Aug;37(4):582-586. doi: 10.1007/s11596-017-1776-y. Epub 2017 Aug 8. PMID: 28786065. 8: Larson M, Larson M, Li Z, Larson M, Li Z, Hall CL, Jensen E, McAllister DM, Kalyanaraman B, Zhao M. Physiological fluctuation of (99m)Tc-sestamibi uptake in normal mammary glands: a systematic investigation in female rats. Acta Radiol. 2009 Nov;50(9):975-8. doi: 10.3109/02841850903134127. PMID: 19863405. 9: Bacovsky J, Myslivecek M, Scudla V, Koranda P, Buriankova E, Minarik J, Pika T, Zapletalova J. Tc-99m MIBI scintigraphy in multiple myeloma: prognostic value of different Tc-99m MIBI uptake patterns. Clin Nucl Med. 2010 Sep;35(9):667-70. doi: 10.1097/RLU.0b013e3181e9f92e. PMID: 20706038. 10: Patil PV. Tc-99m adherence and dose reduction in myocardial perfusion imaging. J Nucl Cardiol. 2016 Apr;23(2):268-70. doi: 10.1007/s12350-015-0273-6. Epub 2015 Sep 24. PMID: 26403141.

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 777.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.