NOTA-NOC is a somatostatin receptor-targeting peptide conjugate, where NOC (1-Nal³-octreotide) is a somatostatin analog with high affinity for somatostatin receptor subtypes 2 and 5 (SSTR2, SSTR5), and NOTA is a chelator for radiometals such as ⁶⁸Ga, ⁶⁴Cu, or ¹⁷⁷Lu. When labeled with ⁶⁸Ga, [⁶⁸Ga]Ga-NOTA-NOC shows strong and specific binding to SSTR2-positive tumors, with reported IC₅₀ values in the low nanomolar range (e.g., ~1.9 nM for SSTR2). In vivo PET imaging studies in animal models and patients have demonstrated high tumor uptake, rapid blood clearance, and favorable tumor-to-background ratios, making it suitable for diagnostic imaging of neuroendocrine tumors. The pharmacokinetics and tumor-targeting efficiency are comparable to or slightly improved over the more commonly used DOTA-NOC analogs, depending on the radiometal and formulation.
MedKoo Cat#: 129064
Name: NOTA-NOC acetate
CAS#: 2170388-37-9
Chemical Formula: C65H87N13O15S2
Exact Mass: 1353.5900
Molecular Weight: 1354.61
Elemental Analysis: C, 57.63; H, 6.47; N, 13.44; O, 17.72; S, 4.73
The following data is based on the product molecular weight 1,354.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Dam JH, Langkjær N, Baun C, Olsen BB, Nielsen AY, Thisgaard H. Preparation and Evaluation of [18F]AlF-NOTA-NOC for PET Imaging of Neuroendocrine Tumors: Comparison to [68Ga]Ga-DOTA/NOTA-NOC. Molecules. 2022 Oct 12;27(20):6818. doi: 10.3390/molecules27206818. PMID: 36296411; PMCID: PMC9609173.
