Crinia-angiotensin | CAS# 72007-47-7 | Angiotensin II-like undecapeptide

MedKoo Cat#: 592422 | Name: Crinia-angiotensin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Crinia-angiotensin is an Angiotensin II-like undecapeptide from skin of Australian frog Crinia georgiana.

Chemical Structure

Crinia-angiotensin

CAS# 72007-47-7

Theoretical Analysis

MedKoo Cat#: 592422

Name: Crinia-angiotensin

CAS#: 72007-47-7

Chemical Formula: C60H66N16O15

Exact Mass: 1270.6459

Molecular Weight: 1271.46

Elemental Analysis: C, 56.68; H, 6.82; N, 17.63; O, 18.87

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Crinia-angiotensin

IUPAC/Chemical Name

L-Phenylalanine, N-(1-(N-(N-(N-(N-(N(2)-(N-(N-(1-L-alanyl-L-prolyl)glycyl)-L-alpha-aspartyl)-L-arginyl)-L-isoleucyl)-L-tyrosyl)-L-valyl)-L-histidyl)-L-prolyl)-

InChi Key

RTJTXSIZQYTCMX-JMUWNTLFSA-N

InChi Code

InChI=1S/C60H86N16O15/c1-6-33(4)49(74-50(81)39(15-10-22-65-60(62)63)69-51(82)41(28-47(79)80)68-46(78)30-66-53(84)44-16-11-23-75(44)57(88)34(5)61)56(87)70-40(25-36-18-20-38(77)21-19-36)52(83)73-48(32(2)3)55(86)71-42(27-37-29-64-31-67-37)58(89)76-24-12-17-45(76)54(85)72-43(59(90)91)26-35-13-8-7-9-14-35/h7-9,13-14,18-21,29,31-34,39-45,48-49,77H,6,10-12,15-17,22-28,30,61H2,1-5H3,(H,64,67)(H,66,84)(H,68,78)(H,69,82)(H,70,87)(H,71,86)(H,72,85)(H,73,83)(H,74,81)(H,79,80)(H,90,91)(H4,62,63,65)/t33-,34-,39-,40-,41-,42-,43-,44-,45-,48-,49-/m0/s1

SMILES Code

O=C(O)[C@H](CC1=CC=CC=C1)NC([C@H]2N(C([C@H](CC3=CNC=N3)NC([C@H](C(C)C)NC([C@H](CC4=CC=C(O)C=C4)NC([C@H]([C@@H](C)CC)NC([C@H](CCCNC(N)=N)NC([C@H](CC(O)=O)NC(CNC([C@H]5N(C([C@H](C)N)=O)CCC5)=O)=O)=O)=O)=O)=O)=O)=O)CCC2)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,271.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Calabrese AN, Markulic K, Musgrave IF, Guo H, Zhang L, Bowie JH. Structural and activity changes in three bioactive anuran peptides when Asp is replaced by isoAsp. Peptides. 2012 Dec;38(2):427-36. doi: 10.1016/j.peptides.2012.10.001. Epub 2012 Oct 13. PubMed PMID: 23069634. 2: Andreazza HJ, Wang T, Bagley CJ, Hoffmann P, Bowie JH. Negative ion fragmentations of deprotonated peptides. The unusual case of isoAsp: a joint experimental and theoretical study. Comparison with positive ion cleavages. Rapid Commun Mass Spectrom. 2009 Jul;23(13):1993-2002. doi: 10.1002/rcm.4107. PubMed PMID: 19489040. 3: Denton DA, Blair-West JR, McBurnie M, Osborne PG, Tarjan E, Williams RM, Weisinger RS. Angiotensin and salt appetite of BALB/c mice. Am J Physiol. 1990 Oct;259(4 Pt 2):R729-35. PubMed PMID: 2221138. 4: Siragy H, Howell N, Rose CE Jr, Khosla MC, Peach MJ, Carey RM. Intrarenal effects of [Ala-Pro-Gly-(Ile3-Val5)] angiotensin II in the conscious dog. Endocrinology. 1988 Jan;122(1):359-63. PubMed PMID: 3275540. 5: Erspamer V, Erspamer GF, Mazzanti G, Endean R. Active peptides in the skins of one hundred amphibian species from Australia and Papua New Guinea. Comp Biochem Physiol C. 1984;77(1):99-108. PubMed PMID: 6141890. 6: Proto MC, Coviello A, Khosla MC, Bumpus FM. Effects of frog-skin angiotensin II in amphibians. Hypertension. 1983 Nov-Dec;5(6 Pt 3):V101-4. PubMed PMID: 6418648. 7: Cantalamessa F, de Caro G, Massi M, Micossi LG. Drinking stimulation by a new angiotensin, crinia-angiotensin II, in rats and pigeons. Pharmacol Biochem Behav. 1982 Oct;17(4):741-7. PubMed PMID: 7178184. 8: Khosla MC, Bumpus FM, Yasuhara T, Nakajima T. Synthesis of ala-pro-gly-[Ile3, Val5]angiotensin II isolated from the skin of the australian frog Crinia georgiana. J Med Chem. 1981 Jul;24(7):885-7. PubMed PMID: 7277399. 9: Erspamer GF, Nakajima T, Yasuhara T. Pharmacological data on crinia-angiotensin II. J Pharm Pharmacol. 1979 Oct;31(10):720. PubMed PMID: 41055. 10: Erspamer V, Melchiorri P, Nakajima T, Yasuhara T, Endean R. Amino acid composition and sequence of crinia-angiotensin, an angiotensin II-like endecapeptide from the skin of the Australian frog Crinia georgiana. Experientia. 1979 Sep 15;35(9):1132-3. PubMed PMID: 488254.