Synonym
Denaverine Free Base; Denaverina; Spasmalgan
IUPAC/Chemical Name
2-(Dimethylamino)ethyl (2-ethylbutoxy)diphenylacetate
InChi Key
FPTOUQZVCUIPHY-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H33NO3/c1-5-20(6-2)19-28-24(21-13-9-7-10-14-21,22-15-11-8-12-16-22)23(26)27-18-17-25(3)4/h7-16,20H,5-6,17-19H2,1-4H3
SMILES Code
O=C(OCCN(C)C)C(C1=CC=CC=C1)(OCC(CC)CC)C2=CC=CC=C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
| Solubility |
| To be determined |
0.0 |
0.00 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
383.53
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Lange K, Heuwieser W, Fischer-Tenhagen C. Influence of denaverine hydrochloride on calving ease in Holstein-Friesian heifers. J Dairy Sci. 2019 Jun;102(6):5410-5418. doi: 10.3168/jds.2018-14930. Epub 2019 Mar 21. PMID: 30904301.
2: Lange K, Heuwieser W, Fischer-Tenhagen C. Effect of denaverine hydrochloride application to heifers on the APGAR score and lactate concentration in newborn calves. Tierarztl Prax Ausg G Grosstiere Nutztiere. 2018 Jun;46(3):150-153. English. doi: 10.15653/TPG-170844. Epub 2018 Jun 14. PMID: 29902814.
3: Zobel R, Taponen J. Denaverine hydrochloride and carbetocin increased welfare during and after parturition and enhanced subsequent fertility in cattle. J Dairy Sci. 2014;97(6):3570-7. doi: 10.3168/jds.2013-7535. Epub 2014 Apr 14. PMID: 24731624.
4: Staab A, Schug BS, Larsimont V, Elze M, Thümmler D, Mutschler E, Blume H. Pharmacokinetics and bioavailability of denaverine hydrochloride in healthy subjects following intravenous, oral and rectal single doses. Eur J Pharm Sci. 2003 Feb;18(2):121-8. doi: 10.1016/s0928-0987(02)00225-7. PMID: 12594004.
5: Kilian B, Oertel R, Kirch W. Determination of denaverine and its metabolites in urine samples by liquid chromatography-tandem mass spectrometry. J Chromatogr A. 2008 May 2;1189(1-2):339-46. doi: 10.1016/j.chroma.2007.09.083. Epub 2007 Oct 11. PMID: 17980885.
6: Borchert HH, Pipping H, Pfeifer S. Metabolische Wechselwirkungen von Denaverin [Metabolic interactions of denaverine]. Pharmazie. 1985 Oct;40(10):720-2. German. PMID: 3936060.
7: Staab A, Scheithauer S, Fieger-Büschges H, Mutschler E, Blume H. A validated high-performance liquid chromatographic assay for the simultaneous determination of denaverine and its N-monodemethyl metabolite in human plasma. J Chromatogr B Biomed Sci Appl. 2001 Feb 25;751(2):221-8. doi: 10.1016/s0378-4347(00)00473-4. PMID: 11236077.
8: Künzel J, Geisler K, Hoffmann I, Müller A, Beckmann MW, Dittrich R. Myometrial response to neurotropic and musculotropic spasmolytic drugs in an extracorporeal perfusion model of swine uteri. Reprod Biomed Online. 2011 Jul;23(1):132-40. doi: 10.1016/j.rbmo.2011.03.026. Epub 2011 Apr 15. PMID: 21757131.
9: Bredow V. Die Anwendung von Tramadol- versus Pethidin- versus Denaverin- suppositorien unter der Geburt--ein Beitrag zur nichtinvasiven Geburtsschmerztherapie [Use of tramadol versus pethidine versus denaverine suppositories in labor--a contribution to noninvasive therapy of labor pain]. Zentralbl Gynakol. 1992;114(11):551-4. German. PMID: 1481587.
10: Göber B, Lisowski H, Friese D, Franke P. Biotransformation von Denaverin (Spasmalgan) bei der Ratte [Biotransformation of denaverin (Spasmalgan) in the rat]. Pharmazie. 1988 Jul;43(7):493-5. German. PMID: 3222282.
