MedKoo Cat#: 123073 | Name: Protoporphyrin IX Zinc
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an potent, orally active and competitive heme oxygenase-1 (HO-1) inhibitor.

Chemical Structure

Protoporphyrin IX Zinc
Protoporphyrin IX Zinc
CAS#15442-64-5

Theoretical Analysis

MedKoo Cat#: 123073

Name: Protoporphyrin IX Zinc

CAS#: 15442-64-5

Chemical Formula: C34H32N4O4Zn

Exact Mass: 624.1700

Molecular Weight: 626.03

Elemental Analysis: C, 65.23; H, 5.15; N, 8.95; O, 10.22; Zn, 10.44

Price and Availability

Size Price Availability Quantity
5mg USD 625.00 2 Weeks
25mg USD 1,350.00 2 Weeks
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Synonym
Protoporphyrin IX Zinc; Zinc protoporphyrin 15442-64-5; PROTOPORPHYRINATO ZINC; Zinc protoporphyrin-9; PROTOPORPHYRIN IX CONTAINING ZN
IUPAC/Chemical Name
zinc(II) 12-(2-carboxyethyl)-8-(2-carboxylatoethyl)-3,7,13,18-tetramethyl-2,17-divinylporphyrin-21-ide
InChi Key
FUTVBRXUIKZACV-RGGAHWMASA-L
InChi Code
InChI=1S/C34H34N4O4.Zn/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);/q;+2/p-2/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;
SMILES Code
C=CC1=C(/C2=C/C(C(C)=C/3CCC([O-])=O)=NC3=C/C4=N/C(C(C)=C4CCC(O)=O)=C\C5=C(C(C)=C(N5)/C=C1\[N-]2)C=C)C.[Zn+2]
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 626.03 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Exogenous Hemin enhances the antioxidant defense system of rice by regulating the AsA-GSH cycle under NaCl stress. PeerJ. 2024 Apr 19;12:e17219. doi: 10.7717/peerj.17219. PMID: 38650645; PMCID: PMC11034499. 5: Yamada T, Katsumi M, Ishii K, Komatsu T. Zinc-Substituted Hemoglobin-Albumin Cluster as a Porphyrin-Carrier for Enhanced Photodynamic Therapy. Chem Asian J. 2024 Jun 3;19(11):e202400257. doi: 10.1002/asia.202400257. Epub 2024 May 14. PMID: 38632107. 6: Ikebudu VC, Nkuna M, Ndou N, Ajayi RF, Chivasa S, Cornish K, Mulaudzi T. Carbon Monoxide Alleviates Salt-Induced Oxidative Damage in Sorghum bicolor by Inducing the Expression of Proline Biosynthesis and Antioxidant Genes. Plants (Basel). 2024 Mar 10;13(6):782. doi: 10.3390/plants13060782. PMID: 38592836; PMCID: PMC10974450. 7: Murmiliuk A, Iwase H, Kang JJ, Mohanakumar S, Appavou MS, Wood K, Almásy L, Len A, Schwärzer K, Allgaier J, Dulle M, Gensch T, Förster B, Ito K, Nakagawa H, Wiegand S, Förster S, Radulescu A. Polyelectrolyte-protein synergism: pH- responsive polyelectrolyte/insulin complexes as versatile carriers for targeted protein and drug delivery. J Colloid Interface Sci. 2024 Jul;665:801-813. doi: 10.1016/j.jcis.2024.03.156. Epub 2024 Mar 23. PMID: 38555748. 8: Schivazappa C, Simoncini N, Pinna A, Faccioli A, Zambonelli P, Virgili R. Zinc-protoporphyrin formation in nitrite-free Parma Ham and its relationship with intrinsic parameters and red color profile of processed hams. Meat Sci. 2024 Jul;213:109477. doi: 10.1016/j.meatsci.2024.109477. Epub 2024 Mar 2. PMID: 38492321. 9: Abe H, Zhai Y, Toba Y, Masumo H, Hayakawa T, Kumura H, Wakamatsu JI. Water extractability of the zinc protoporphyrin IX-myoglobin complex from Parma ham is pH-dependent. Food Chem. 2024 May 30;441:138317. doi: 10.1016/j.foodchem.2023.138317. Epub 2024 Jan 2. PMID: 38199102. 10: Namulinda T, Yan YJ, Wang LH, Qiu Y, Jin H, Kwetegyeka J, Gumula I, Atassi Y, Karam S, Chen ZL. pH-responsive Photinia glabra-zinc oxide- protoporphyrin IX nanoconjugates with enhanced cellular uptake for photodynamic therapy towards cancer cells. Nanomedicine (Lond). 2024 Jan;19(2):127-143. doi: 10.2217/nnm-2023-0242. Epub 2023 Dec 22. PMID: 38131290. 11: Yang Z, Chen G, Liao G, Zheng Z, Zhong Y, Wang G. UHPLC-MS/MS-based lipidomics for the evaluation of the relationship between lipid changes and Zn- protoporphyrin formation during Nuodeng ham processing. Food Res Int. 2023 Dec;174(Pt 1):113509. doi: 10.1016/j.foodres.2023.113509. Epub 2023 Sep 23. PMID: 37986504. 12: Wu Y, Deng J, Xu F, Li X, Kong L, Li C, Xu B. Zinc protoporphyrin IX generation by Leuconostoc strains isolated from bulged pasteurized vacuum sliced hams. Food Res Int. 2023 Dec;174(Pt 1):113500. doi: 10.1016/j.foodres.2023.113500. Epub 2023 Sep 23. PMID: 37986415. 13: Schliemann A, Homann C, Hennig G, Lang A, Holdt LM, Vogeser M, Sroka R, Stepp H, Weinauer F, Quenzel EM. Non-Invasive Zinc Protoporphyrin Screening Offers Opportunities for Secondary Prevention of Iron Deficiency in Blood Donors. Transfus Med Hemother. 2023 Jan 24;50(4):303-312. doi: 10.1159/000528545. PMID: 37767275; PMCID: PMC10521216. 14: Hamidizad Z, Kadkhodaee M, Kianian F, Ranjbaran M, Seifi B. The effects of CORM3 or NaHS on the oxidative stress caused by chronic kidney disease in rats: potential interaction between CO and H2S signaling pathway. Metab Brain Dis. 2023 Dec;38(8):2653-2664. doi: 10.1007/s11011-023-01264-w. Epub 2023 Sep 11. PMID: 37695421. 15: Zhou Y, Chen J, Pu W, Cai N, Che B, Yang J, Wang M, Zhong S, Zuo X, Wang D, Wang Y, Zheng P, Sun J. Development of a growth-coupled selection platform for directed evolution of heme biosynthetic enzymes in Corynebacterium glutamicum. Front Bioeng Biotechnol. 2023 Aug 15;11:1236118. doi: 10.3389/fbioe.2023.1236118. PMID: 37654705; PMCID: PMC10465345. 16: Zhao X, Cheng H, Wang Q, Nie W, Yang Y, Yang X, Zhang K, Shi J, Liu J. Regulating Photosensitizer Metabolism with DNAzyme-Loaded Nanoparticles for Amplified Mitochondria-Targeting Photodynamic Immunotherapy. ACS Nano. 2023 Jul 25;17(14):13746-13759. doi: 10.1021/acsnano.3c03308. Epub 2023 Jul 12. Erratum in: ACS Nano. 2023 Nov 28;17(22):23221-23222. doi: 10.1021/acsnano.3c10514. PMID: 37438324. 17: Zhai Y, Abe H, Wang HC, Hayakawa T, Kumura H, Wakamatsu JI. Dissociation of ferriheme from oxidized heme proteins and re-reduction of ferriheme to ferroheme are crucial for the formation of zinc protoporphyrin IX in nitrite/nitrate-free dry-cured meat products. Food Chem. 2023 Nov 30;427:136755. doi: 10.1016/j.foodchem.2023.136755. Epub 2023 Jun 27. PMID: 37399643. 18: Obata M, Hirohara S. RAFT Synthesis and Characterization of Poly(Butyl-co-2-(N,N-Dimethylamino)Ethyl Acrylates)-block-Poly(Polyethylene Glycol Monomethyl Ether Acrylate) as a Photosensitizer Carrier for Photodynamic Therapy. Materials (Basel). 2023 Jun 5;16(11):4192. doi: 10.3390/ma16114192. PMID: 37297326; PMCID: PMC10254196. 19: Lozano-Ordaz V, Rodriguez-Miguez Y, Ortiz-Cabrera AE, Hernandez-Bazan S, Mata-Espinosa D, Barrios-Payan J, Saavedra R, Hernandez-Pando R. Beneficial or detrimental activity of regulatory T cells, indoleamine 2,3-dioxygenase, and heme oxygenase-1 in the lungs is influenced by the level of virulence of Mycobacterium tuberculosis strain infection. Front Cell Infect Microbiol. 2023 May 22;13:1105872. doi: 10.3389/fcimb.2023.1105872. PMID: 37284503; PMCID: PMC10239976. 20: He Q, Zheng R, Ma J, Zhao L, Shi Y, Qiu J. Responsive manganese-based nanoplatform amplifying cGAS-STING activation for immunotherapy. Biomater Res. 2023 Apr 15;27(1):29. doi: 10.1186/s40824-023-00374-x. PMID: 37061706; PMCID: PMC10105937.