MedKoo Cat#: 128753 | Name: GRP94 Inhibitor 1
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

GRP94 inhibitor 1 is a ligand of glucose-regulated protein 94 (GRP94; IC50 = 2 nM in a fluorescence polarization assay).

Chemical Structure

GRP94 Inhibitor 1
GRP94 Inhibitor 1
CAS#2234897-35-7

Theoretical Analysis

MedKoo Cat#: 128753

Name: GRP94 Inhibitor 1

CAS#: 2234897-35-7

Chemical Formula: C22H28N2O2

Exact Mass: 352.2151

Molecular Weight: 352.48

Elemental Analysis: C, 74.97; H, 8.01; N, 7.95; O, 9.08

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
10mg USD 550.00 2 Weeks
25mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
GRP94 Inhibitor 1;
IUPAC/Chemical Name
4-(((1r,4r)-4-hydroxycyclohexyl)amino)-4'-isopropyl-[1,1'-biphenyl]-3-carboxamide
InChi Key
JMGDXIHGWTVBMX-WGSAOQKQSA-N
InChi Code
InChI=1S/C22H28N2O2/c1-14(2)15-3-5-16(6-4-15)17-7-12-21(20(13-17)22(23)26)24-18-8-10-19(25)11-9-18/h3-7,12-14,18-19,24-25H,8-11H2,1-2H3,(H2,23,26)/t18-,19-
SMILES Code
NC(C(C=C(C1=CC=C(C=C1)C(C)C)C=C2)=C2N[C@@H]3CC[C@H](CC3)O)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 352.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Jiang, F., Guo, A.-P., Xu, J.-C., et al. Discovery of a potent Grp94 selective inhibitor with anti-inflammatory efficacy in a mouse model of ulcerative colitis. J. Med. Chem. 61(21), 9513-9533 (2018).