Norethindrone is a steroidal progestin used in some combined oral contraceptive pills and progestogen-only pills, and is also available as a standalone drug. It can be used to treat premenstrual syndrome, painful periods, abnormal heavy bleeding, irregular periods, menopausal syndrome (in combination with estrogen), or to postpone a period. It is also commonly used to help prevent uterine hemorrhage in complicated non-surgical or pre-surgical gynecologic cases and in treating non responsive cyclical mastalgia. Norethisterone was the first orally highly active progestin to be synthesized.
MedKoo Cat#: 318378
Name: Norethindrone
CAS#: 68-22-4
Chemical Formula: C20H26O2
Exact Mass: 298.1933
Molecular Weight: 298.42
Elemental Analysis: C, 80.50; H, 8.78; O, 10.72
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.5 | 142.42 | |
| Ethanol | 3.0 | 10.05 | |
| Water | 2.7 | 9.05 |
The following data is based on the product molecular weight 298.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
